Veidlapa Nr. M-3 (8)
Study Course Description
Transplant Immunology, Tissue Typing
Course Code
RTL_001
Branch of Science
Clinical medicine; Surgery
ECTS
6.00
Target Audience
Medicine
LQF
Level 8
Study Course Implementer
Course Supervisor
Jānis Jušinskis
Residency Speciality
Speciality
Transplantologist
Supervisor of Medical Speciality
Jānis Jušinskis
Contacts
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About Study Course
Objective
To ensure the acquisition of theoretical knowledge and practical skills that would correspond to the general knowledge in transplant immunology and immunological criteria for the selection of the donor/recipient pair in order to prepare the doctor for certification in the specialty of transplantology, in accordance with the regulatory documents of the Republic of Latvia.
Learning Outcomes
Knowledge
1.The resident acquires basic knowledge and competence in transplant immunology, immunological selection criteria and common immunological problems (pre-sensitization, rejection, DSA) and their diagnostic possibilities.
Skills
1.The resident will know how to determine the donor/recipient pair according to immunological criteria, determine the increased immunological risk in transplantation, and correctly determine the diagnostic algorithm.
Competences
1.The resident will be able to correctly determine the donor/recipient pair, observing the peculiarities of immunological selection, and determine the need for additional immunological examination.
Assessment
Individual work
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Title
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% from total grade
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Grade
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1.
Individual work |
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The resident must acquire theoretical knowledge of transplant immunology: basic knowledge on humoral and cellular rejection; histocompatibility antigens (MHC), nomenclature, HLA structure, HLA phenotypes and genotypes; The role of T-lymphocytes, antigen-presenting cells, costimulation, adhesive molecules, endothelium, cytokines in the development of rejection; mechanisms of rejection of transplanted organs; tolerance, xenotransplantation from the point of view of immunology; tissue typing technique; DNA typing; for cross-match test variants; determination of presensitization; the importance of tissue typing in practical transplantology and the influence of the choice of donor-recipient pairs on the results of organ transplantation; donor/recipient pair selection algorithm, treatment methods of pre-sensitized recipients .
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Examination
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Title
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% from total grade
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Grade
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1.
Examination |
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-
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student independently prepares the material and presents it to persons responsible for leading the seminar, answers questions
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2.
Examination |
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-
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- At the end of the cycle, the teacher evaluates the practical skills in a 10-point system, recording it in the resident's book.
- The test of theoretical knowledge is conducted in writing and is graded in a 10-point system.
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Study Course Theme Plan
FULL-TIME
Part 1
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Seminar
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Modality
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Location
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On site
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Laboratory
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Topics
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Transplantation immunology. Tissue compatibility. ABO, HLA compatibility. "Cross-match". Presensitization and its importance. Donor-specific antibodies. Virtual "cross-match". (Prof. I. Ziediņa, D. Amerika-Ļebedkova).
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Seminar
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Modality
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Location
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On site
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Laboratory
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Topics
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Acute and chronic rejection – immunological aspects, immunological diagnosis and treatment control. (Prof. I. Ziediņa, D. Amerika-Ļebedkova)
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Total ECTS (Creditpoints):
6.00
Number of Residency Seminars:
2
Length (weeks):
4
Final Examination:
Residency exam (Theory and practice)
Bibliography
Required Reading
1.
Rekomendācijas nieru transplantācijā. (autoru kolektīvs, R.Rozentāla vad.). Medicīnas Apgāds, Rīga, 2015.
2.
Nieru transplantācija (red. R.Rozentāls, I.Folkmane). Nacionālais Apgāds, Rīga, 2008.
3.
Guide to the quality and safety of organs for transplantation. 7th edition. EDQM, Strasbourg, 2018.
4.
Textbook of organ transplantation, vol 1, 2. (edit. Allan D. Kirk). Willey Blackwell, Oxford, 2014.
Additional Reading
1.
Gabriel M.Danovich. Handook of kidney transplantation. 5th edition. Lippincott Williams & Wilkins, Philadelphia, 2010.
2.
Рафаил Розенталь. Получение органов, тканей и клеток для трансплантации. Nacionālais Apgāds, Rīga, 2005.
3.
Atlas of Organ Transplantation
Other Information Sources
1.
Periodika: Transplant International, Nephrology Dialysis Transplantation, Transplantation Proceedings, Transplantation, JAMA, Lancet, NEJM