Veidlapa Nr. M-3 (8)

Study Course Description

General Haematology

Main Study Course Information

Course Code

RHE_064

Branch of Science

Clinical medicine

ECTS

8.00

Target Audience

Medicine

LQF

Level 8

Study Course Implementer

Course Supervisor

Sandra Lejniece

Residency Speciality

Speciality

Hematologist

Supervisor of Medical Speciality

Sandra Lejniece

Contacts

About Study Course

Objective

To ensure acquisition and improvement of theoretical knowledge and practical skills in general haematology in accordance with the requirements of the haematology specialty in order to prepare the doctor for certification in the haematology specialty.

Learning Outcomes

Knowledge

1.- Will know about deficiency anaemias, anaemias in case of chronic diseases; - Will know about pure red cell aplasia; - Will know about erythrocytosis, primary and secondary haemochromatosis; - Will know about haemolytic anaemias; - Will know about thalassaemia, sickle cell anaemia, microspherocytosis, acquired haemolytic anaemias; - Will know about lymphopenias and lymphocyte dysfunction syndrome, acquired immunodeficiency states; - Will know about haematological changes during pregnancy; - Will know about haematological manifestations of HIV and other infectious diseases.

Skills

1.- Will know how to diagnose and treat deficiency anaemias, haemolytic anaemias, pregnant women with haematological changes.

Competences

1.Diagnosis and treatment of deficiency anaemia, haemolytic anaemias, pregnant women with haematological changes.

Assessment

Individual work

Title	% from total grade	Grade
1. Individual work	-	-
1. Independently studies the literature related to the course topics; 2. Independently prepares for seminars; 3. Independently collects disease anamnesis data, objectively examines the patient, formulates a preliminary diagnosis, which is discussed with the lecturer; 4. Gets acquainted with and analyses medical documentation; 5. Completes medical documentation; 6. Independently follows the instructions of the certified specialist.

Examination

Title	% from total grade	Grade
1. Examination	-	-
Mandatory attendance of seminars (100%) and performance of practical work (100%) in each study course.

Study Course Theme Plan

FULL-TIME

Part 1

Seminar

Modality	Location
-	-

Topics

Deficiency anaemias. Anaemias in case of chronic diseases. Anaemia due to exposure to toxic substances. Pure red cell aplasia. Erythrocytosis. Primary and secondary haemochromatosis.

Seminar

Modality	Location
-	-

Topics

Haemolytic anaemias. Thalassemia. Sickle cell anaemia. Microspherocytosis. Enzymopathies. Acquired haemolytic anaemias.

Seminar

Modality	Location
-	-

Topics

Lymphopenia and lymphocyte dysfunction syndromes. Acquired immunodeficiency states. Hemophagocytic lymphohistiocytosis.

Seminar

Modality	Location
-	-

Topics

Haematological manifestations of other diseases.

Seminar

Modality	Location
-	-

Topics

Haematological changes during pregnancy.

Seminar

Modality	Location
-	-

Topics

Haematological manifestations of HIV and other infectious diseases.

Total ECTS (Creditpoints):

8.00

Number of Residency Seminars:

Length (weeks):

Final Examination:

Residency exam (Theory and practice)

Bibliography

Required Reading

“Klīniskā medicīna” Prof. A.Lejnieka redakcijā. 1. daļa, nodaļa “Asinsrades sistēma un ar to saistītās slimības”, 783-928 lpp, Medicīnas apgāds, 2010.

“Klīniskā medicīna” Prof. Aivara Lejnieka redakcijā, 3. daļa, nodaļa “Laboratoriskā diagnostika”, Medicīnas apgāds, 2012.

"Ķirurģija", prof. Jāņa Gardovska redakcijā. 2. Atkārotais izdevums. Nodaļa “Liesas slimības”, 869-884.lpp., Rīgas Stradiņa Universitāte, 2013.

S. Lejniece. “Dzelzs deficīta anēmija”, Nacionālais Medicīnas apgāds, 2015.

Dzemdniecība. Prof. D.Rezebergas redakcijā. Anēmija grūtniecības laikā, 609-622 lpp., Trombocitopēnija un grūtniecība, 623-628 lpp, Tromboze un grūtniecība, 697-708 lpp, Medicīnas Apgāds, 2016.

S. Lejniece. “Klīniskā hematoloģija”, Nacionālais medicīonasn apgāds, 2020.

Additional Reading

Hill Q. A., Stamps R., Massey E., Grainger J. D., et al. British Society for Haematology Guidelines. Guidelines on the management of drug-induced immune and secondary autoimmune, haemolytic anaemia. Br J Haematol. 2017 Apr;177(2):208-220. doi: 10.1111/bjh.14654. Epub 2017 Apr 3. PMID: 28369704.

Jäger U., Barcellini W., Broome C. M., et al. Diagnosis and treatment of autoimmune hemolytic anemia in adults: Recommendations from the First International Consensus Meeting. Blood Rev. 2020 May;41:100648. doi: 10.1016/j.blre.2019.100648. Epub 2019 Dec 5. PMID: 31839434.

Farias M. G. Advances in laboratory diagnosis of hereditary spherocytosis. Clin Chem Lab Med. 2017 Jun 27;55(7):944-948. doi: 10.1515/cclm-2016-0738. PMID: 27837594.

Kohne E. Hemoglobinopathies: clinical manifestations, diagnosis, and treatment. Dtsch Arztebl Int. 2011 Aug;108(31-32):532-40. doi: 10.3238/arztebl.2011.0532. Epub 2011 Aug 8. PMID: 21886666; PMCID: PMC3163784.

Badawy S. M., Cronin R. M., Hankins J., et al. Patient-Centered eHealth Interventions for Children, Adolescents, and Adults With Sickle Cell Disease: Systematic Review. J Med Internet Res. 2018 Jul 19;20(7):e10940. doi: 10.2196/10940. PMID: 30026178; PMCID: PMC6072976.

King M. J., Garçon L., Hoyer J. D., Iolascon A., et al. International Council for Standardization in Haematology. ICSH guidelines for the laboratory diagnosis of nonimmune hereditary red cell membrane disorders. Int J Lab Hematol. 2015 Jun;37(3):304-25. doi: 10.1111/ijlh.12335. Epub 2015 Mar 18. PMID: 25790109.

Friman V., Winqvist O., Blimark C., Langerbeins P., Chapel H., Dhalla F. Secondary immunodeficiency in lymphoproliferative malignancies. Hematol Oncol. 2016 Sep;34(3):121-32. doi: 10.1002/hon.2323. Epub 2016 Jul 12. PMID: 27402426.

Chinen J., Shearer W. T. Secondary immunodeficiencies, including HIV infection. J Allergy Clin Immunol. 2010 Feb;125(2 Suppl 2):S195-203. doi: 10.1016/j.jaci.2009.08.040. Epub 2009 Dec 29. PMID: 20042227; PMCID: PMC6151868.

Sánchez-Ramón S., Bermúdez A., González-Granado L. I., Rodríguez-Gallego C., Sastre A., Soler-Palacín P.; ID-Signal Onco-Haematology Group. Primary and Secondary Immunodeficiency Diseases in Oncohaematology: Warning Signs, Diagnosis, and Management. Front Immunol. 2019 Mar 26;10:586. doi: 10.3389/fimmu.2019.00586. PMID: 30984175; PMCID: PMC6448689.

10.

Martire B., Azzari C., Badolato R., Canessa C., et al.; with Italian Network for Primary Immunodeficiencies (IPINET). Vaccination in immunocompromised host: Recommendations of Italian Primary Immunodeficiency Network Centers (IPINET). Vaccine. 2018 Jun 7;36(24):3541-3554. doi: 10.1016/j.vaccine.2018.01.061. Epub 2018 Feb 6. Erratum in: Vaccine. 2018 Nov 29;36(50):7753. PMID: 29426658.

11.

Salama H. A., Jazieh A.R, Alhejazi A. Y., et al. Highlights of the Management of Adult Histiocytic Disorders: Langerhans Cell Histiocytosis, Erdheim-Chester Disease, Rosai-Dorfman Disease, and Hemophagocytic Lymphohistiocytosis. Clin Lymphoma Myeloma Leuk. 2021 Jan;21(1):e66-e75. doi: 10.1016/j.clml.2020.08.007. Epub 2020 Aug 18. PMID: 32943371;

12.

Esteban Y. M., de Jong J. L. O., Tesher M. S. An Overview of Hemophagocytic Lymphohistiocytosis. Pediatr Ann. 2017 Aug 1;46(8):e309-e313. doi: 10.3928/19382359-20170717-01. PMID: 28806468.

13.

Hayden A., Park S., Giustini D., Lee A. Y., Chen L. Y. Hemophagocytic syndromes (HPSs) including hemophagocytic lymphohistiocytosis (HLH) in adults: A systematic scoping review. Blood Rev. 2016 Nov;30(6):411-420. doi: 10.1016/j.blre.2016.05.001. Epub 2016 May 20. PMID: 27238576.

14.

Kowdley K. V., Brown K. E., Ahn J., Sundaram V. ACG Clinical Guideline: Hereditary Hemochromatosis. Am J Gastroenterol. 2019 Aug;114(8):1202-1218. doi: 10.14309/ajg.0000000000000315. Erratum in: Am J Gastroenterol. 2019 Dec;114(12):1927. PMID: 31335359.

15.

Gulati V., Harikrishnan P., Palaniswamy C., Aronow W. S., Jain D., Frishman W. H. Cardiac involvement in hemochromatosis. Cardiol Rev. 2014 Mar-Apr;22(2):56-68. doi: 10.1097/CRD.0b013e3182a67805. PMID: 24503941.

16.

Becker S. Comparing Care of the Primary and Secondary Hemochromatosis Patients. J Infus Nurs. 2020 Mar/Apr;43(2):65-69. doi: 10.1097/NAN.0000000000000358. PMID: 32106193.