Veidlapa Nr. M-3 (8)
Study Course Description
Stem Cell Transplantation
Course Code
RHE_060
Branch of Science
Clinical medicine
ECTS
8.00
Target Audience
Medicine
LQF
Level 8
Study Course Implementer
Course Supervisor
Sandra Lejniece
Residency Speciality
Speciality
Hematologist
Supervisor of Medical Speciality
Sandra Lejniece
Contacts
-
About Study Course
Objective
To ensure acquisition and improvement of theoretical knowledge and practical skills in stem cell transplantation in accordance with the requirements of the haematology specialty in order to prepare the doctor for certification in the haematology specialty.
Learning Outcomes
Knowledge
1.- Will know about the indications, risks and benefits of autologous and allogeneic transplantation; - Will know about the mobilisation and collection of hematopoietic stem cells; - Will know about the prescription of high-dose chemotherapy; - Will know about acute and chronic graft-versus-host disease; - Will know about lung complications, hepatic veno-occlusive disease, hemorrhagic cystitis; - Will know about chimerism analysis.
Skills
1.- Will be able to determine indications for autologous and allogeneic transplantation; - Will know how to mobilise and collect hematopoietic stem cells; - Will be able to prescribe high-dose chemotherapy.
Competences
1.Patient preparation before and after transplantation.
Assessment
Individual work
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Title
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% from total grade
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Grade
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|---|---|---|
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1.
Individual work |
-
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-
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1. Independently studies the literature related to the course topics;
2. Independently prepares for seminars;
3. Independently collects disease anamnesis data, objectively examines the patient, formulates a preliminary diagnosis, which is discussed with the lecturer;
4. Gets acquainted with and analyses medical documentation;
5. Completes medical documentation;
6. Independently follows the instructions of the certified specialist.
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Examination
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Title
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% from total grade
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Grade
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|---|---|---|
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1.
Examination |
-
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-
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Mandatory attendance of seminars (100%) and performance of practical work (100%) in each study course.
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Study Course Theme Plan
FULL-TIME
Part 1
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Seminar
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Modality
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Location
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|---|---|---|
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-
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-
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Topics
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Indications, risks and benefits of autologous and allogeneic transplantation.
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-
Seminar
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Modality
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Location
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|---|---|---|
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-
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-
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Topics
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Sources, mobilisation, collection of hematopoietic stem cells and manipulations with them. Identification and selection of hematopoietic progenitor cells.
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-
Seminar
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Modality
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Location
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|---|---|---|
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-
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-
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Topics
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Prescription of high-dose chemotherapy.
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-
Seminar
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Modality
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Location
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|---|---|---|
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-
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-
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Topics
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Acute and chronic graft-versus-host disease
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-
Seminar
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Modality
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Location
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|---|---|---|
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-
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-
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Topics
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Pulmonary complications, hepatic veno-occlusive disease, hemorrhagic cystitis.
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-
Seminar
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Modality
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Location
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|---|---|---|
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-
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-
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Topics
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Chimerism analysis, its role in the post-transplantation period
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Total ECTS (Creditpoints):
8.00
Number of Residency Seminars:
6
Length (weeks):
6
Final Examination:
Residency exam (Theory and practice)
Bibliography
Required Reading
1.
Hematopoietic Stem Cell Transplantation, Karam Khaddour; Caroline K. Hana; Prerna Mewawalla., Last Update: June 28, 2020.
2.
Transfusion Medicine and Hemostasis Clinical and Laboratory Aspects, Book Third Edition 2019, Edited by: Beth H. Shaz, Christopher D. Hillyer and Morayma Reyes Gil.
3.
Hematopoietic Stem Cell Transplantation: A Manual for Nursing Practice (Third Edition), Kimberly Schmit-Pokorny, Seth Eisenberg, 2020.
4.
Stem Cell Mobilization. Methods and Protocols, Editors: Klein, Gerd, Wuchter, Patrick (Eds.), 2019.
5.
Stem Cells and Cell Therapy, Editors: Al-Rubeai, Mohamed, Naciri, Mariam (Eds.), 2014.
6.
Quality Management and Accreditation in Hematopoietic Stem Cell Transplantation and Cellular Therapy, The JACIE Guide, Editors: Aljurf, M.D., Snowden, J.A., Hayden, P., Orchard, K., McGrath, E. (Eds.), 2021.
7.
Regenerative Medicine and Stem Cell Biology, Editors: El-Badri Abdelkodous, Nagwa (Ed.), 2020.
8.
Overview of Hematopoietic Stem Cell Transplantation (HSCT). Daniel R Couriel, MD Sarah Cannon Blood and Marrow Transplant Program. Hematopoiesis. T-lymphocytes. Stem Cells. B-lymphocytes. Granulocytes. Monocytes. Eosinophils. Basophils. Erythrocytes. Megakaryocytes. Platelets.Uploaded on Sep 10, 2014.
9.
Emile JF, Abla O, Fraitag S, et al. Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages. Blood 2016; 127:2672.
10.
S.Lejniece. Klīniskā hematoloģija. Medicīnas Apgāds, 2020.
11.
Klīnisko analīžu rokasgrāmata. E.Gulbja laboratorija. Izdevējs E.Gulbja laboratorija, 2019.
12.
Alla Rivkina. Plūsmas citometrijas metode hematoloģisko slimību diagnostikā. SIA Medicīnas apgāds, 2019
Other Information Sources
1.
Arber DA, Orazi A, Hasserjian R, et al. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood 2016; 127:2391-2405. https://doi.org/10.1182/blood-2016-03-643544
2.
Hematopoietic Stem Cell Transplantation. Available from: https://www.ncbi.nlm.nih.gov/books/NBK536951/
3.
Leukemia - Patien Version National Cancer Institute. Available from: https://www.cancer.gov/types/leukemia
4.
What is a blood steam cell transplant? Available from: https://www.bmtinfonet.org/transplant-article/what-blood-stem-cell-transplant
5.
Hematopoietic Stem Cell Transplantation. Available from: https://www.winchesterhospital.org/health-library/article?id=14774