Veidlapa Nr. M-3 (8)
Study Course Description
Organic Chemistry
Course Code
LFK_018
Branch of Science
Basic medicine
ECTS
14.00
Target Audience
Pharmacy
LQF
Level 7
Study Type And Form
Full-Time; Part-Time
Study Course Implementer
Course Supervisor
Māra Plotniece
Structure Unit Manager
Baiba Mauriņa
Structural Unit
Department of Applied Pharmacy
Contacts
Riga, 21 Consula Street, farmkk@rsu.lv, +371 67061544
About Study Course
Objective
Learn basic course of organic chemistry for further understanding of biochemistry, medical chemistry and pharmaceutical science.
Preliminary Knowledge
Knowledge of organic chemistry within the programme of secondary school, inorganic chemistry, laboratory techniques.
Learning Outcomes
Knowledge
1.On successful course completion students will: • identify functional groups of organic compounds and explain their properties and possibilities of mutual conversions; • interpret relations of special structures of molecules with their properties; • identify structures of heterocyclic compounds and their properties; • interpret reactions of organic compounds on the bases of the main principles of reaction mechanisms.
Skills
1.On successful course completion students will: • recognize functional groups in drug molecules, name them, know the chemical properties and identification reactions of the group; • select and apply correct methods for isolation and purification of organic compounds; • evaluate chemical structures of drug substances in connection with their pharmacological actions.
Competences
1.On successful course completion students will choose and interpret chemical and physical methods of identification and functional analysis of organic compounds.
Assessment
Individual work
|
Title
|
% from total grade
|
Grade
|
|---|---|---|
|
1.
Individual work |
-
|
-
|
|
Individual laboratory experiments, problem solving, preparation, presentation and defence of literature research on specific drug substance. Individual work with home tasks, laboratory work protocol processing, studying of lecture materials. It is recommended to fill in the study course survey, evaluating the existing course content and creating proposals for updating the course.
|
||
Examination
|
Title
|
% from total grade
|
Grade
|
|---|---|---|
|
1.
Examination |
-
|
-
|
|
1. Knowledge evaluation during practical sessions – discussions, seminars, colloquia, evaluation of results of experimental work;
2. Application of theoretical knowledge in practical tasks;
3. Assessment of student's attitude (activity in seminars, ability to improve knowledge, ability to work in a team explaining to others, attendance);
4. Analysis of unknown substance at the end of semester 3, performing various reactions and drawing conclusions on the presence of functional groups in the molecule;
5. Semester test at the end of the 2nd semester;
6. Written examination at the end of the 3rd semester.
|
||
Study Course Theme Plan
FULL-TIME
Part 1
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Basic of organic chemistry
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
3
|
Topics
|
Seminar: nomenclature of organic compounds. Test: nomenclature of organic compounds.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
3
|
Topics
|
Seminar: acidity and basicity of organic compounds, stereochemistry. Test: acidity and basicity of organic compounds, stereochemistry.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Hydrocarbons.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Hydrocarbons.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
3
|
Topics
|
Colloquium: Basic of organic chemistry
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
3
|
Topics
|
Practical work: chemical properties and identification reactions of hydrocarbons.
Seminar: chemical properties and identification reactions of hydrocarbons. Test: chemical properties and identification reactions of hydrocarbons.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
3
|
Topics
|
Practical work: chemical properties and identification reactions of hydrocarbons.
Seminar: chemical properties and identification reactions of hydrocarbons. Test: chemical properties and identification reactions of hydrocarbons.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Introduction to spectroscopy (IR un 1H NMR spectroscopy for identification of organic compounds)
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Organic halides, alcohols, phenols, ethers, sulfur containing compounds.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
3
|
Topics
|
Colloquium: hydrocarbons
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
3
|
Topics
|
Practical work and seminar: chemical properties and identification reactions of organic halides, alcohols, phenols, ethers, sulfur containing compounds
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
3
|
Topics
|
Colloquium: organic halides, alcohols, phenols, ethers, sulfur containing compounds.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Carbonylcompounds: Aldehydes and ketones
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
3
|
Topics
|
Practical work: chemical properties and identification reactions of aldehydes and ketones
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Amines, diazonium ions, azocompounds and other nitrogen containing compounds
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Amines, diazonium ions, azocompounds and other nitrogen containing compounds
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
3
|
Topics
|
Colloquium: aldehydes and ketones (carbonylcompounds).
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
3
|
Topics
|
Practical work: chemical properties and identification reactions of amines, diazonium ions and azocompounds.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
3
|
Topics
|
Seminar: chemical properties and identification reactions of amines, diazonium ions and azocompounds.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Carboxylic acids
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Carboxylic acid derivatives, different functional group containing carboxylic acids, derivatives of carbonic acid, sulfonic acids.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
3
|
Topics
|
Colloquium: amines, diazonium ions and azocompounds
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
3
|
Topics
|
Practical work: chemical properties and identification reactions of carboxylic acids and their derivatives. Seminar: chemical properties and identification reactions of carboxylic acids and their derivatives.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
3
|
Topics
|
Colloquium: carboxylic acids and their derivatives.
FINNAL TEST
|
Total ECTS (Creditpoints):
6.00
Contact hours:
65 Academic Hours
Final Examination:
Test (Semester)
Part 2
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Heterocycles
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Heterocycles
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
5
|
Topics
|
Practical work: Purification of organic com-pounds: crystallization, fractional distillation, sublimation, extraction.
Colloquium: Basic of organic chemistry.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
5
|
Topics
|
Practical work: Purification of organic com-pounds: crystallization, fractional distillation, sublimation, extraction.
Colloquium: Basic of organic chemistry.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
5
|
Topics
|
Seminar: Heterocycles: clasification and no-menclature, heterocycles with one heteroatom, heterocycles with two heteroatoms, purine, pteridine, alkaloids.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
5
|
Topics
|
Practical work: Synthesis of organic compounds (individual work)
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
5
|
Topics
|
Practical work: Synthesis of organic compounds (individual work)
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
5
|
Topics
|
Practical work: Synthesis of organic compounds (individual work)
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Carbohydrates
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Carbohydrates
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
5
|
Topics
|
Test: Carbohydrates
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
5
|
Topics
|
Colloquium: Heterocycles. Seminar: Carbohydrates.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
5
|
Topics
|
Colloquium: Heterocycles. Seminar: Carbohydrates.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
5
|
Topics
|
Colloquium: Carbohydrates.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Aminoacids, peptides, nucleic acids
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
5
|
Topics
|
Seminar: Aminoacids, peptides, nucleic acids.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
5
|
Topics
|
Seminar: Lipids. Practical work: Identification of organic compound using chemical and spectroscopic methods.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
5
|
Topics
|
Seminar: Lipids. Practical work: Identification of organic compound using chemical and spectroscopic methods.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Lipids. Cholesterol.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
5
|
Topics
|
Colloquium: Lipids, cholesterol.
|
Total ECTS (Creditpoints):
8.00
Contact hours:
82 Academic Hours
Final Examination:
Exam (Written)
PART-TIME
Part 1
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
4
|
Topics
|
Basic of organic chemistry
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
4
|
Topics
|
Hydrocarbons.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
4
|
Topics
|
Hydrocarbons.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Practical work: chemical properties and identification reactions of hydrocarbons.
Seminar: chemical properties and identification reactions of hydrocarbons. Test: chemical properties and identification reactions of hydrocarbons.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
4
|
Topics
|
Organic halides, alcohols, phenols, ethers, sulfur containing compounds.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Colloquium: hydrocarbons
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Practical work and seminar: chemical properties and identification reactions of organic halides, alcohols, phenols, ethers, sulfur containing compounds
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Colloquium: organic halides, alcohols, phenols, ethers, sulfur containing compounds.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
4
|
Topics
|
Carbonylcompounds: Aldehydes and ketones
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
4
|
Topics
|
Amines, diazonium ions, azocompounds and other nitrogen containing compounds
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Colloquium: aldehydes and ketones (carbonylcompounds).
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Practical work: chemical properties and identification reactions of amines, diazonium ions and azocompounds.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Seminar: chemical properties and identification reactions of amines, diazonium ions and azocompounds.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
4
|
Topics
|
Carboxylic acids
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
4
|
Topics
|
Dicarboxylic acids
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
4
|
Topics
|
Carboxylic acid derivatives, different functional group containing carboxylic acids, derivatives of carbonic acid, sulfonic acids.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Colloquium: carboxylic acids and their derivatives.
FINNAL TEST
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
4
|
Topics
|
Heterocycles
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Test: Heterocycles
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Seminar: Heterocycles: clasification and no-menclature, heterocycles with one heteroatom, heterocycles with two heteroatoms, purine, pteridine, alkaloids.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
4
|
Topics
|
Carbohydrates
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Colloquium: Carbohydrates.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Colloquium: Carbohydrates.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
4
|
Topics
|
Aminoacids, peptides, nucleic acids
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
4
|
Topics
|
Lipids. Cholesterol.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
4
|
Topics
|
Lipids. Cholesterol.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Colloquium: Aminoacids, peptides, nucleic acids.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Colloquium: Aminoacids, peptides, nucleic acids.
|
Total ECTS (Creditpoints):
14.00
Contact hours:
112 Academic Hours
Final Examination:
Exam (Written)
Bibliography
Required Reading
1.
P.M. Dewick. Essentiasl of Organic Chemistry. John Wiley & Son’s, England, 2006. (akceptējams izdevums)
2.
K.P.C. Vollhardt, N.E. Shore. Organic Chemistry: Structure and Function. 7th ed. New York, N.Y. : W.H. Freeman and Company, 2014.
3.
Органическая химия. Книга 1. Подред. Н.А. Тюкавкиной. М. 2003. (akceptējams izdevums)
4.
Органическая химия. Книга 2.Спец.курсс. Подред. Н.А. Тюкавкиной. М. 2009. (akceptējams izdevums)
5.
T.W. Graham Solomons. Solomons' Organic Chemistry. University of South Florida, 2017.
Additional Reading
1.
R. Valters. Organiskā ķīmija (speckurss). RTU Rīga, 2009
2.
R. Valters. Heterociklisko savienojumu ķīmija. RTU Rīga, 1995.
3.
R. Valters. Kodolu magnētiskās rezonanses spektroskopija. RTU Rīga, 2008.
4.
V. Alagarsamy. Pharmaceutical Organic Chemistry. BSP BOOKS, 2020, e-book.
5.
Rawn, J. David; Ouellette, Robert J. Organic Chemistry: structure, mechanism, and synthesis. 1st ed. San Diego, CA : Elsevier. 2014. eBook.
6.
Тюкавкина Н.А. Бауков Ю.И. Биоорганическая химия. М. 1991.
7.
Armarego, W. L. F.; Chai, Christina Li Lin. Purification of laboratory chemicals. 6th ed. Oxford : Butterworth-Heinemann. 2012. eBook.
8.
Ārvalstu studentiem/For international students
9.
V. Alagarsamy. Pharmaceutical Organic Chemistry. BSP BOOKS, 2020, e-book.
10.
Armarego, W. L. F.; Chai, Christina Li Lin. Purification of laboratory chemicals. 6th ed. Oxford : Butterworth-Heinemann. 2012. eBook.