Veidlapa Nr. M-3 (8)
Study Course Description
Biology and Medical Genetics
Course Code
LF_401
Branch of Science
Clinical medicine; Health care sciences and services
ECTS
3.00
Target Audience
Medicine; Nursing Science
LQF
Level 5
Study Type And Form
Full-Time
Study Course Implementer
Course Supervisor
Līga Ēriksone
Structure Unit Manager
Dita Role
Structural Unit
RSU Liepāja Branch
Contacts
Liepāja, Riņķu Street 24/26, lf@rsu.lv, +371 63442118, +371 63442119, +371 63484632
About Study Course
Objective
To acquire knowledge of the human being as a system; the role of genetic processes in the maintenance of health and the development of metabolic diseases; the effects of teratogenic external environmental factors in embryogenesis; the role of parasites in the development of disease; and the necessary skills to apply this knowledge.
Preliminary Knowledge
In general biology according to the secondary school curriculum.
Learning Outcomes
Knowledge
1.Students analyse the relevance of the cell structure of various eukaryotes to their functions; substantiates the role of the relationship between cell structure and abnormal functions in human pathology; compares the processes occurring in mitosis and meiosis; knows the main regularities of genetics; evaluates the significance of Mendel’s experiments in the development of genetics; compares the results of monohybrid, dihybrid, polyhybrid and analytic crosses; explains DNA replication, transcription, translation; knows chromosomal pathologies, the reasons for occurrence thereof, classifies the inheritance types of genetic traits and pathologies; justifies one’s opinion by analysing specific situations regarding the inheritance of human traits; explains the morphology, possible infestation, life cycle, pathogenicity and symptoms of parasites commonly found in Latvia, localisation in the human body, method of diagnosis and recommends prevention; uses the biological concepts and terms discussed in the lecture and class.
Skills
1.Students use an optical microscope, prepare simple microarrays, identify the most common parasites; identify different eukaryotic cells; different types of metaphase chromosomes; polytene chromosomes; explain the relationship between structure and function; graphically represent the phases of mitosis and meiosis and explain the processes involved; draw diagrams of oogenesis and spermatogenesis; compile and analyse family trees of different types of inheritance; isolate DNA from plant cells; classify types of variation and mutation; discuss mechanisms of gene, chromosome, genome mutations; solve simple tasks related to genetics and molecular biology.
Competences
1.Students analyse situations in medical parasitology, genetics. Evaluate the importance of organoids in the functioning of tissues, organs and the body.
Assessment
Individual work
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Title
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% from total grade
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Grade
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|---|---|---|
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1.
Individual work |
-
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-
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During the study course, students independently perform laboratory work, according to the protocol – preparation of simple microarrays, for example, hair, onion preparation, osmosis in plant and animal cells, as well as DNA isolation from plant cells.
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Examination
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Title
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% from total grade
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Grade
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|---|---|---|
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1.
Examination |
-
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-
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Students’ participation in classes and adherence to methodology in laboratory work are assessed; weekly test of theoretical knowledge, ability to explain the results of practical work, draw conclusions according to the obtained results.
Student knowledge and skills are assessed in 2 seminars:
1. – cell biology
2. – medical genetics
Final examination of the study course – multiple-choice questions, if the student has an average assessment of more than 8 points in the colloquia during the course, the results of the colloquia are equivalent to the exam.
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Study Course Theme Plan
FULL-TIME
Part 1
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Lecture
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Modality
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Location
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Contact hours
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|---|---|---|
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On site
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Auditorium
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2
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Topics
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The subject of human biology. Diversity of life forms. Cell structure of living organisms. Cell theory. Prokaryotes, eukaryotes. Viruses, bacteria – symptoms and clinics of the pathology caused.
Biological membranes. The structure and function of the plasma membrane. Transport of substances through the membrane. Cell communication. Membrane defects as a cause of human disease.
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-
Class/Seminar
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Modality
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Location
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Contact hours
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|---|---|---|
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On site
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Auditorium
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2
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Topics
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Interactive tasks. Microscope. Structure of the optical microscope, work with it.
Diversity of living organisms.
Prokaryotes. Eukaryotes.
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-
Class/Seminar
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Modality
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Location
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Contact hours
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|---|---|---|
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On site
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Auditorium
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2
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Topics
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Interactive tasks. Microscope. Structure of the optical microscope, work with it.
Diversity of living organisms.
Prokaryotes. Eukaryotes.
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-
Lecture
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Modality
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Location
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Contact hours
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|---|---|---|
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On site
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Auditorium
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2
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Topics
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Cell cycle, regulation thereof. Types of cell division. Mitosis. Disorders of cell division, and pathology of the human body. Meiosis. Gametogenesis. Conception. Cell death.
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Lecture
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Modality
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Location
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Contact hours
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|---|---|---|
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On site
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Auditorium
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2
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Topics
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Human genetics. Genetic methods. The main regularities of trait inheritance. Mendelian traits. The main regularities of trait inheritance. Types of gene interaction, importance thereof in human genetics. Gene linkage.
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-
Class/Seminar
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Modality
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Location
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Contact hours
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|---|---|---|
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On site
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Auditorium
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2
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Topics
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Cell division – mitosis, meiosis in microarrays. Germ cells in microarrays.
Colloquium.
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-
Class/Seminar
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Modality
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Location
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Contact hours
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|---|---|---|
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On site
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Auditorium
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2
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Topics
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Cell division – mitosis, meiosis in microarrays. Germ cells in microarrays.
Colloquium.
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-
Lecture
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Modality
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Location
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Contact hours
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|---|---|---|
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On site
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Auditorium
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2
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Topics
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Cytoplasm, its components. Hyaloplasm. Inclusions. Organoids, their structure and functions. Organoid structure and function disorders – the cause of pathologies in the body. Cell nucleus, its components. Chromatin. Types of chromatin. Chromosomes. Human karyotype.
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Lecture
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Modality
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Location
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Contact hours
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|---|---|---|
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On site
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Auditorium
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2
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Topics
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Cytoplasm, its components. Hyaloplasm. Inclusions. Organoids, their structure and functions. Organoid structure and function disorders – the cause of pathologies in the body. Cell nucleus, its components. Chromatin. Types of chromatin. Chromosomes. Human karyotype.
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Lecture
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Modality
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Location
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Contact hours
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|---|---|---|
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On site
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Auditorium
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2
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Topics
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The main types of trait inheritance. Analysis of different types of inheritance. Monogenic types of inheritance. Human traits, examples of congenital anomalies. Multifactorial type of inheritance. Mitochondrial type of inheritance. Importance of genetic pathology in clinical practice.
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Class/Seminar
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Modality
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Location
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Contact hours
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|---|---|---|
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On site
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Auditorium
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2
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Topics
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Structure, components of a eukaryotic cell. Plasma membrane, its functions, transport function. Organoids, structure, function, pathology. Cell nucleus, structure thereof.
Laboratory work: osmotic properties of a cell. Interactive tasks.
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-
Class/Seminar
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Modality
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Location
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Contact hours
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|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
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Structure, components of a eukaryotic cell. Plasma membrane, its functions, transport function. Organoids, structure, function, pathology. Cell nucleus, structure thereof.
Laboratory work: osmotic properties of a cell. Interactive tasks.
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-
Class/Seminar
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Modality
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Location
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Contact hours
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|---|---|---|
|
On site
|
Auditorium
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2
|
Topics
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Chromosomes. Human karyotype. Chromatin. Types of cell division. Mitosis. Mitotic cycle. Meiosis. Gametogenesis. Errors during cell division. Cell death. Interactive tasks.
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-
Class/Seminar
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Modality
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Location
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Contact hours
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|---|---|---|
|
On site
|
Auditorium
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2
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Topics
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Chromosomes. Human karyotype. Chromatin. Types of cell division. Mitosis. Mitotic cycle. Meiosis. Gametogenesis. Errors during cell division. Cell death. Interactive tasks.
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-
Class/Seminar
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Modality
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Location
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Contact hours
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|---|---|---|
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On site
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Auditorium
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2
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Topics
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Inheritance of traits. Inheritance of traits in mono-, di-, and polyhybrid crosses. Inheritance types of monogenic traits. Analysis of family tree preparation. Multifactorial type of inheritance. Mitochondrial type of inheritance.
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-
Class/Seminar
|
Modality
|
Location
|
Contact hours
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|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Inheritance of traits. Inheritance of traits in mono-, di-, and polyhybrid crosses. Inheritance types of monogenic traits. Analysis of family tree preparation. Multifactorial type of inheritance. Mitochondrial type of inheritance.
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Total ECTS (Creditpoints):
3.00
Contact hours:
32 Academic Hours
Final Examination:
Exam (Written)
Bibliography
Required Reading
1.
Lekciju materiāls
2.
Nagle E. Bioloģija vidusskolai – 2008. (akceptējams izdevums)
3.
Krūmiņa A. Eikariotu šūnu bioloģija : citoloģiskie, molekulāri bioloģiskie un ģenētiskie aspekti, 2015
4.
Balodis V. un citi Rokasgrāmata bioloģijā - 2015
5.
L.Zinčenko un citi Medicīniskā parazitoloģija - 2015.
6.
Pollard T. D., Earnshaw W. C. Cell Biology. – Elsevier Science (USA), 2017. – 789 p.
7.
Turnpenny P. D., Ellard S. Emery's Elements of Medical Genetics and Genomics. 16th Edition Elsevier, Churchill Livingstone, 2022.
Additional Reading
1.
Selga Tūrs. Šūnu bioloģija. LU akadēmiskais apgāds. 2008.- 342 lpp.
2.
Zalcmane V., Groma V. Šūnas ultrastruktūra. RSU, 2004
Other Information Sources
1.
www.ncbi.nlm.nih.gov