Veidlapa Nr. M-3 (8)
Study Course Description
Perspective Dosage Forms
Course Code
LFK_032
Branch of Science
Basic medicine; Pharmaceutical Chemistry; Technology of Drug Forms
ECTS
3.00
Target Audience
Pharmacy
LQF
Level 7
Study Type And Form
Full-Time
Study Course Implementer
Course Supervisor
Ance Bārzdiņa
Structure Unit Manager
Baiba Mauriņa
Structural Unit
Department of Applied Pharmacy
Contacts
Riga, 21 Konsula Street, zftk@rsu.lv, +371 67061547
About Study Course
Objective
- Promote knowledge acquisition and understanding of innovative drug delivery systems (nanoparticles, hydrogels, implant materials, etc.), their diversity, properties, materials used in synthesis, in vitro analysis methods, and potential pharmaceutical applications.
- Strengthen students’ translational skills on the steps of developing a prospective drug form by linking the physico-chemical properties of a drug substance with potential solutions to healthcare problems.
Preliminary Knowledge
Basic knowledge in organic chemistry, pharmaceutical chemistry, analytical chemistry, medical chemistry, physical pharmacy, anatomy, normal physiology, pharmacology, pharmaceutical form technology, English language.
Learning Outcomes
Knowledge
1.Recognise and characterise the more common drug delivery systems, their classification and their use in the pharmaceutical field
Individual work and tests
Test • Individual work • Presentation
2.Will recognize anatomical and physiological barriers that may make delivery of drug substances difficult
Individual work and tests
Presentation • Test • Development of course presentation • Individual work
3.Will be able to identify key physical and chemical parameters of drug substances that will influence drug delivery system selection
Individual work and tests
Individual work • Test • Development of course presentation • Presentation
4.Will be able to identify key in vitro analysis methods for the characterisation of nanoparticles and hydrogels
Individual work and tests
Presentation • Test • Laboratory work • Mastering the theoretical base of laboratory work • Individual work
5.Will be able to classify and characterise materials to be used in the synthesis of drug delivery systems
Individual work and tests
Individual work • Test • Mastering the theoretical base of laboratory work • Development of course presentation • Presentation
6.Identify microneedle types and their pros and cons
Individual work and tests
Test • Individual work
Skills
1.Will be able to choose the appropriate drug delivery system based on the physical and chemical properties of the drug molecule
Individual work and tests
Mastering the theoretical base of laboratory work • Individual work • Development of course presentation • Presentation
2.Will be able to define key steps in the development and characterisation of drug delivery systems
Individual work and tests
Laboratory work • Test • Individual work • Mastering the theoretical base of laboratory work
3.Will be able to identify the type of nanoparticles based on their chemical composition
Individual work and tests
Mastering the theoretical base of laboratory work • Individual work • Test • Laboratory work
4.Will be able to select an appropriate type of crosslinker based on the compounds used in hydrogel synthesis
Individual work and tests
Test • Laboratory work • Mastering the theoretical base of laboratory work • Individual work
5.Will be able to define the main directions and obstacles to the development of innovative drug delivery systems
Individual work and tests
Individual work • Test
Competences
1.Will be able to evaluate the quality of information available in scientific literature and elsewhere regarding common drug delivery systems and critically evaluate the use possibilities of such delivery systems in the pharmaceutical field.
Individual work and tests
Presentation • Selection of scientific literature • Development of course presentation
2.Will be able to offer innovative drug delivery system-based solutions to a wide range of pharmacokinetic and pharmacodynamic problems.
Individual work and tests
Development of course presentation • Individual work • Presentation
Assessment
Individual work
|
Title
|
% from total grade
|
Grade
|
|---|---|---|
|
1.
Individual work |
-
|
-
|
|
Listening to video recordings of lectures in E-studies and reading other provided materials in E-studies |
||
|
2.
Mastering the theoretical base of laboratory work |
-
|
-
|
|
Independent familiarity with the theoretical descriptions of laboratory work, the progress of work, as well as repetition of the safety aspects of laboratory work |
||
|
3.
Selection of scientific literature |
-
|
-
|
|
Independent selection of subject-related scientific literature for seminar and student-developed presentation |
||
|
4.
Development of course presentation |
-
|
-
|
|
Independently develop a presentation based on a coherent theme |
||
Examination
|
Title
|
% from total grade
|
Grade
|
|---|---|---|
|
1.
Test |
10.00% from total grade
|
10 points
|
|
Test “Innovative drug delivery systems - basic principles, pros and cons, ways of administration and operation, biological barriers” |
||
|
2.
Test |
10.00% from total grade
|
10 points
|
|
Test “Natural and synthetic polymers — characteristics, properties, application in innovative drug dlievery systems” |
||
|
3.
Test |
10.00% from total grade
|
10 points
|
|
Test “Lipids and inorganic compounds — characteristics, properties, application in prospective pharmaceutical forms” |
||
|
4.
Test |
10.00% from total grade
|
10 points
|
|
Test “Classification, properties, comparison, pros and cons of nanoparticles, materials used” |
||
|
5.
Test |
10.00% from total grade
|
10 points
|
|
Test “Nanoparticles — synthesis methods, in vitro characterisation, examples” |
||
|
6.
Test |
10.00% from total grade
|
10 points
|
|
Test “Hydrogels – types, properties, materials, cross-linking methods, in vitro characterisation, examples” |
||
|
7.
Test |
10.00% from total grade
|
10 points
|
|
Test “Microneedles – types, characteristics, pros and cons, examples” |
||
|
8.
Test |
10.00% from total grade
|
10 points
|
|
Test “Future perspective and obstacles to the development of drug delivery systems” |
||
|
9.
Laboratory work |
-
|
Test
|
|
Laboratory work Protocol “Nanoparticle synthesis and characterization” |
||
|
10.
Laboratory work |
-
|
Test
|
|
Laboratory work protocol “Synthesis and characterisation of hydrogels” |
||
|
11.
Presentation |
20.00% from total grade
|
10 points
|
|
Presentation of the student’s theoretically developed innovative drug delivery system |
||
Study Course Theme Plan
FULL-TIME
Part 1
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
Off site
|
Video
|
2
|
Topics
|
Innovative drug delivery systems — basic principles, pros and cons, administration and action types, biological barriers
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
Off site
|
Video
|
2
|
Topics
|
Natural and synthetic polymers — characterisation, properties, application in drug delivery systems
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
Off site
|
Video
|
2
|
Topics
|
Lipids and inorganic compounds – characteristics, properties, application in drug delivery systems
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
Off site
|
Video
|
2
|
Topics
|
Nanoparticles I — Classification, characteristics, comparison, pros and cons, materials used
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
Off site
|
Video
|
2
|
Topics
|
Nanoparticles II — synthesis methods, in vitro characterisation, examples
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
Off site
|
Video
|
2
|
Topics
|
Hydrogels – types, properties, materials, cross-linking methods, in vitro characterization, examples
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
Off site
|
Video
|
2
|
Topics
|
Microneedles – types, characteristics, pros and cons, examples
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
Off site
|
Video
|
2
|
Topics
|
Other innovative drug delivery systems - examples, characteristics, future perspective
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
Laboratory work - synthesis and characterisation of nanoparticles
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
Laboratory work - hydrogel synthesis
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
Laboratory work - characterisation of hydrogels
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
-
|
2
|
Topics
|
Study tour I - Development of innovative drug delivery systems in Latvia
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
-
|
2
|
Topics
|
Study tour II - Development of prospective drug forms in Latvia
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
2
|
Topics
|
Seminar - critical analysis of scientific literature related to the development of drug delivery systems
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
2
|
Topics
|
Seminar I - presentations on independent work
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
2
|
Topics
|
Seminar II - presentations on independent work
|
Total ECTS (Creditpoints):
3.00
Contact hours:
32 Academic Hours
Final Examination:
Exam (Written)
Bibliography
Required Reading
1.
Drug Delivery Systems. 2020. Edited by Rakesh K. Tekade. London : Academic Press an imprint of ElsevierSuitable for English stream
2.
Emerging Approaches in Novel Drug Delivery System. 2024. Preeti Singh; Gunjan Singh; Amrish Chandra; Nayyar Parvez. Available from: eBook Academic Collection (EBSCOhost)Suitable for English stream
3.
Stimuli Responsive Drug Delivery Systems: From Introduction to Application. 2010. Bajpai, Anil; Shukla, Sandeep; Saini, Rajesh; Tiwari, Atul. Available from: eBook Academic Collection (EBSCOhost)Suitable for English stream
4.
Nanomaterials Evolution and Advancement Towards Therapeutic Drug Delivery (Part I). 2021. Ramesh, Chandra; Nidhi, Gupta; Surendra, Nimesh. Available from: eBook Academic Collection (EBSCOhost)Suitable for English stream
5.
Nanomaterials Evolution and Advancement Towards Therapeutic Drug Delivery (Part II). 2021. Surendra, Nimesh; Nidhi, Gupta; Ramesh, Chandra. Available from: eBook Academic Collection (EBSCOhost).Suitable for English stream
6.
Hydrogels: Synthesis, Characterization and Applications. 2012. Ferreira, Leandro J.; Camara, Fabricio Vitor. Available from: eBook Academic Collection (EBSCOhost)Suitable for English stream
Additional Reading
1.
Applications of Polymers in Drug Delivery. 2014. Misra, Ambikanandan; Shahiwala, Aliasgar. Available from: eBook Academic Collection (EBSCOhost).Suitable for English stream
2.
Drug Carriers. 2022. Edited by Luis Jesús Villarreal-Gómez. Available from: eBook Collection (EBSCOhost).Suitable for English stream
3.
Nanotechnology in Drug Delivery: Strategies, Technologies and Applications. 2013. Haghi, A. K.; Castro, E. A. Available from: eBook Academic Collection (EBSCOhost).Suitable for English stream