Veidlapa Nr. M-3 (8)
Study Course Description
Pharmacogenetics
Course Code
LFK_052
Branch of Science
Basic medicine; Other basic medicines
ECTS
2.00
Target Audience
Pharmacy
LQF
Level 7
Study Type And Form
Full-Time; Part-Time
Study Course Implementer
Course Supervisor
Agnija Kivrāne
Structure Unit Manager
Baiba Mauriņa
Structural Unit
Department of Applied Pharmacy
Contacts
Riga, 21 Consula Street, zftk@rsu.lv, +371 67061544
About Study Course
Objective
To introduce students to the basic concepts of pharmacogenetics, research methods and the application of pharmacogenetics tests in modern health care.
Preliminary Knowledge
In biology, pharmacology and human genetics.
Learning Outcomes
Knowledge
1.As a result of completing the study course, students acquire basic knowledge in the theory of pharmacogenetics, i.e. what is pharmacogenetics, what are the types and goals of pharmacogenetics research, how the characteristics of the human genome can affect the effect of medicinal products on the patient’s body and how medical personnel could predict these effects.
Skills
1.As a result of completing the study course, students acquire skills in evaluating the influence of heredity factors in cases of variations in drug action and the ability to search for a solution to the situation. In addition, students will be able to explain social and clinical perspectives on interindividual variability in responses to drug substances.
Competences
1.As a result of completing the study course, students gain competence in issues related to the application of human genome research for the implementation of personalised pharmacotherapy and the design of new pharmacogenetic tests, as well as ethical aspects of pharmacogenetics.
Assessment
Individual work
|
Title
|
% from total grade
|
Grade
|
|---|---|---|
|
1.
Individual work |
-
|
-
|
|
Independent work on the course includes:
|
||
Examination
|
Title
|
% from total grade
|
Grade
|
|---|---|---|
|
1.
Examination |
0.00% from total grade
|
10 points
|
|
During the study course, three works will be evaluated:
Evaluation on a 10-point scale in accordance with the provisions of the RSU academic Regulations. The final assessment of the course is cumulative, taking into account the points received for the three works. |
||
Study Course Theme Plan
FULL-TIME
Part 1
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
Off site
|
Video
|
2
|
Topics
|
Introduction into pharmacogenetics
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
Off site
|
Video
|
2
|
Topics
|
Human genetics
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
Off site
|
Video
|
2
|
Topics
|
Pharmacogenetics of drug-metabolising enzymes I
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
Off site
|
Video
|
2
|
Topics
|
Pharmacogenetics of drug-metabolising enzymes II
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
Off site
|
Video
|
2
|
Topics
|
Pharmacogenetics of drug-metabolising enzymes III
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
Off site
|
Video
|
2
|
Topics
|
Cytochrome P450
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
Off site
|
Video
|
2
|
Topics
|
Pharmacogenetics of drug targets
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
DNA extraction II
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
DNA extraction III
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
DNA extraction III
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
DNA quality control and analysis
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
DNS analīze
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
Seminar – exercises in the pharmacogenetics
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
Presentations about pharmacogenetic studies
|
Total ECTS (Creditpoints):
2.00
Contact hours:
28 Academic Hours
Final Examination:
Exam (Written)
PART-TIME
Part 1
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Introduction into pharmacogenetics
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Human genetics
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Pharmacogenetics of drug-metabolising enzymes I
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Pharmacogenetics of drug-metabolising enzymes II
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Pharmacogenetics of drug-metabolising enzymes II
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Pharmacogenetics of drug-metabolising enzymes III
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Cytochrome P450
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Pharmacogenetics of drug targets
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Pharmacogenetics of drug targets
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
DNA extraction I
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
DNA extraction II
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
DNA extraction III
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
DNS analīze
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Seminar – exercises in the pharmacogenetics
|
Total ECTS (Creditpoints):
2.00
Contact hours:
28 Academic Hours
Final Examination:
Exam (Written)
Bibliography
Required Reading
1.
Clinical Applications of Pharmacogenetics. Edited by Despina Sanoudou. Publisher: InTech, 2012. DOI: 10.5772/1277 (Open Access book). (akceptējams izdevums)
2.
Pharmacogenetics. Wendell W. Weber. Oxford Monographs on Medical Genetics, 2nd edition, 2008. (akceptējams izdevums)
Additional Reading
1.
Pharmacogenomics: Social, Ethical, and Clinical Dimensions. Mark A. Rothstein.Wiley-Liss, 2003.
2.
Biochemistry. D.Voet, J.Voet. Wiley, 2021.
3.
Molecular Biology of the Cell. B.Alberts. Garland, 2022.
Other Information Sources
1.
Tiešsaistes datubāzes: PubMed, Scopus, Web of Science, ClinVar, dbSNP, ClinPGx.