Veidlapa Nr. M-3 (8)
Study Course Description
Immunohaematology
Course Code
RLA_022
Branch of Science
Clinical medicine; Medicinal Biochemistry
ECTS
11.00
Target Audience
Medicine
LQF
Level 8
Study Course Implementer
Course Supervisor
Jeļena Storoženko
Residency Speciality
Speciality
Laboratory doctor
Supervisor of Medical Speciality
Jeļena Storoženko
Contacts
-
About Study Course
Objective
To prepare laboratory doctors capable of using immunohaematological examination methods using necessary equipment, procedures and observing examination rules. To obtain theoretical and practical knowledge in the field of immunohaematology, to interpret the obtained indicators and to be able to choose further examination tactics. To be able to act, if critical values are obtained. To master internal and external quality control principles in immunohaematology.
Learning Outcomes
Knowledge
1.- to characterise clinically significant WBC antigen systems, their clinical role; - to describe test principles used in immunohaematology; - to evaluate results of problematic tests; - to evaluate quality control results for immunohaematological tests; - to characterise anti-RBC antibody formation principles.
Skills
1.- to conduct testing to determine ABO blood group, Rh, phenotype; - to perform screening, identification, titrating of anti-RBC antibodies; - to conduct immunohaematology quality control tests; - to conduct direct and indirect antiglobulin tests; - to interpret immunohaematological tests and their prognostic significance.
Competences
1.To perform immunohaematological examinations with different types of clinical immunohaematological methods, to independently determine blood group, Rh (D) and perform other blood compatibility tests, to perform their interpretation and prognostic meaning.
Assessment
Individual work
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Title
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% from total grade
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Grade
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|---|---|---|
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1.
Individual work |
-
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-
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Preparation of a presentation on formation of anti-RBC antibodies and their significance in transfusion of blood components, about donor and recipient blood compatibility testing.
In-depth research: Immunisation mechanism. Anti-RBC antibodies, their screening, identification. Autoimmune processes.
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Examination
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Title
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% from total grade
|
Grade
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|---|---|---|
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1.
Examination |
-
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-
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2.
Examination |
-
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-
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Assessment of knowledge – written answers to questions at the end of the study course.
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Study Course Theme Plan
FULL-TIME
Part 1
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Seminar
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Modality
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Location
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|---|---|---|
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On site
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Auditorium
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Topics
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Basics of immunohematology. ABO RH, Kell etc. Clinically important antigen systems, genetics D, Dw, Dvariants, their clinical role
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Seminar
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Modality
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Location
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|---|---|---|
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On site
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Auditorium
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Topics
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Mechanism of immunization. Anti-erythrocyte antibodies, screening, identification, titration
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-
Seminar
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Modality
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Location
|
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|---|---|---|
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On site
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Auditorium
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Topics
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Antiglobulin tests, DAT differentiation. Autoimmune processes. Heat antibody-induced, and other hemolytic anemia. Neonatal hemolytic disease
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Seminar
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Modality
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Location
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|---|---|---|
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On site
|
Auditorium
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Topics
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Blood compatibility tests. Transfusion reactions. Quality assurance in the immunohematology laboratory
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Total ECTS (Creditpoints):
11.00
Number of Residency Seminars:
4
Length (weeks):
8
Final Examination:
Residency exam (Theory and practice)
Bibliography
Required Reading
1.
Preanalytical Phase Errors: Experience of a Central Laboratory Monitoring. Editor: Alexander Muacevic and John R. Adler; e7335. Published online 2020 Mar 20. doi: 10.7759/cureus.7335
2.
Autoantibodies. 3rd Revised edition. Edited by Yehuda Shoenfeld, M. E. Gershwin, Pier-Luigi Meroni. Elsevier Science, 2018
3.
Kathleen Deska Pagana, Timothy J. Pagana, Theresa N. Pagana. Mosby's Diagnostic and Laboratory Test Reference. 13th Edition, 2016
4.
Henry's Clinical Diagnosis and Management by Laboratory Methods. 23rd Edition, 2017
5.
Clinical Chemistry and Laboratory Medicine (CCLM). Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM). Editor-in-Chief: Plebani, Mario.
Additional Reading
1.
Fred F. Ferri. Ferri's Best Test. A Practical Guide to Clinical Laboratory Medicine and Diagnostic Imaging. 3rd Edition, 2014
2.
Practical Laboratory Medicine, Journal. Co Editors-in-Chief: William Clarke, Mike J. Hallworth
3.
Kathleen Deska Pagana, Timothy J. Pagana, Theresa N. Pagana. Mosby's Diagnostic and Laboratory Test Reference. 13th Edition, 2016
4.
Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics. 7th Edition, 2014
5.
Eva D. Quinley. Immunohematology: Principles and Practice. 3rd Edition, 2016
Other Information Sources
1.
Practical Laboratory Medicine, Journal. Co Editors-in-Chief: William Clarke, Mike J. Hallworth
2.
The Journal of Laboratory and Clinical Medicine. The Official Publication of the Central Society for Clinical Research
3.
Clinical Chemistry and Laboratory Medicine (CCLM). Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM). Editor-in-Chief: Plebani, Mario.
5.
http://www.ifcc.org/ifcc-communications-publications-division-(cpd)/ifcc-publications/ejifcc-(journal)/