Veidlapa Nr. M-3 (8)
Study Course Description
Methods of Instrumental Analysis
Course Code
LFK_012
Branch of Science
Basic medicine
ECTS
3.00
Target Audience
Pharmacy
LQF
Level 7
Study Type And Form
Full-Time; Part-Time
Study Course Implementer
Course Supervisor
Inga Urtāne
Structure Unit Manager
Baiba Mauriņa
Structural Unit
Department of Applied Pharmacy
Contacts
Riga, 21 Consula Street, farmkk@rsu.lv, +371 67061544
About Study Course
Objective
Promote acquisition of knowledge of the instrumental methods often used in pharmaceutical analysis and practical use of these methods.
Preliminary Knowledge
Physics, mathematics, organic chemistry, quantitative analysis.
Learning Outcomes
Knowledge
1.Upon successful completion of the study programme students will be able to: • formulate and explain the theoretical basis of refractometry, spectrophotometry (UV and IR) and chromatography; • to distinguish and evaluate advantages, disadvantages and application possibilities of instrumental methods.
Skills
1.Upon successful completion of the study program students will be able to: • to evaluate the methods necessary for testing the good of the medicinal product according to the physical and chemical properties of the substances; • use refractometry, UV and IR spectrophotometry, gas (GH) and solution (HPLC) chromatography to verify the identity and quantity of the substances; • use potentiometric titration for quantitative analysis of drug substances.
Competences
1.As a result of the study course students will be able to evaluate instrumental analysis methods and apply them in drug analysis.
Assessment
Individual work
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Title
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% from total grade
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Grade
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|---|---|---|
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1.
Individual work |
-
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-
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Individual work with literature to understand the essence of each method of analysis and its application.
Practical lessons for individual analysis of video materials - preparation of the analyzed sample in spectrophotometry, chromatography, potentiometry; analysis and evaluation of results. Please fill in the study course survey, evaluating the existing course content and creating proposals for updating the course.
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Examination
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Title
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% from total grade
|
Grade
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|---|---|---|
|
1.
Examination |
-
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-
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|
Analysis of analysis video materials and scientific publication (25%), tests during the study course (25%) and exam (50%).
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Study Course Theme Plan
FULL-TIME
Part 1
-
Lecture
|
Modality
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Location
|
Contact hours
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|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Introductory lecture.
Classification of instrumental analysis methods, applications for different samples and analytes.
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-
Lecture
|
Modality
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Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
UV / VIS / IS spectrometry.
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-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
UV / VIS / IS spectrometry.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
UV / VIS / IS spectrometry.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
UV / VIS / IS spectrometry.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Theoretical basis of potentiometry. Potentiometric titration, K. Fischer titration.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
Theoretical basis of potentiometry. Potentiometric titration, K. Fischer titration.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Thin layer chromatography and screening methods
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
Thin layer chromatography and screening methods
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Liquid chromatographic methods
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
Liquid chromatographic methods
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Gas chromatographic methods
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
Gas chromatographic methods
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Mass spectrometric methods - Determination of organic matter
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
Mass spectrometric methods - Determination of organic matter
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Mass spectrometry methods - element analyzes
|
Total ECTS (Creditpoints):
3.00
Contact hours:
32 Academic Hours
Final Examination:
Exam (Written)
PART-TIME
Part 1
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
UV / VIS / IS spectrometry.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
UV / VIS / IS spectrometry.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Liquid chromatographic methods
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Liquid chromatographic methods
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Thin layer chromatography and screening methods
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Liquid chromatographic methods
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Gas chromatographic methods
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Gas chromatographic methods
|
Total ECTS (Creditpoints):
3.00
Contact hours:
32 Academic Hours
Final Examination:
Exam (Written)
Bibliography
Required Reading
1.
Watson, David G. Pharmaceutical Analysis : a textbook for pharmacy students and pharmaceutical chemists / David G. Watson ; with contribution by Bhavik A. Patel. 5th edition. Edinburgh [et al.] : Elsevier, 2021. vi, 462 lpp. (brošēts).
2.
Drug Delivery Systems / edited by Rakesh K. Tekade. London : Academic Press an imprint of Elsevier, [2019], 2020. xiii, 777 lpp. Advances in pharmaceutical product development and research. (iesiets).
3.
Water Extraction of Bioactive Compounds: From Plants to Drug Development. / edited by Herminia Domingues Gonsález, et.al. Amsterdam: Elsevier, 2017. xviii, 466 lpp.
Additional Reading
1.
Handbook of Pharmaceutical Excipients / edited by Paul J. Sheskey, Bruno C. Hancock, Gary P. Moss, David J. Goldfarb. 9th edition. London; Philadelphia : Pharmaceutical Press; Washington, DC : American Pharmaceutical Association, 2020. xxxiv, 1262 lpp. (iesiets).
2.
Gas chromatography: biochemical, biomedical and clinical applications. / Edited by Ray Clement. New York: Wiley, 1990. x, 393 lpp. Chemical analysis, vol. 111.
3.
Instrumentation in Analytical Chemistry. 1988 – 1991. / Edited by Voress L. Washington: American Chemical Society, 1992.