Veidlapa Nr. M-3 (8)
Study Course Description
Quantitative Analysis
Course Code
LFK_002
Branch of Science
Basic medicine
ECTS
6.00
Target Audience
Pharmacy
LQF
Level 7
Study Type And Form
Full-Time
Study Course Implementer
Course Supervisor
Aina Semjonova
Structure Unit Manager
Baiba Mauriņa
Structural Unit
Department of Applied Pharmacy
Contacts
Riga, 21 Consula Street, farmkk@rsu.lv, +371 67061544
About Study Course
Objective
To provide the opportunity to acquire the quantitative chemical and simple instrumental analysis methods widely used in pharmaceutical analysis, to gain insight into their application in practice and to acquire basic skills for work in the laboratory.
Preliminary Knowledge
Inorganic chemistry and Physics within the scope of the Pharmacy program. Organic and Physical Chemistry within the scope of the Secondary school.
Learning Outcomes
Knowledge
1.Upon successful completion of the study course students will be able to: • describe the nature of the most important titrimetric and instrumental methods; • understand the applicability of quantitative analysis methods.
Skills
1.As a result of the study course students: • will be able to choose methods of chemical and instrumental analysis appropriate to the chemical and physical properties of the substances; • will be able to apply them in practice in drug substance analysis; • will be able to calculate and evaluate the results of the analysis; • will be able to work properly with laboratory glassware and various equipment used in analytical chemistry.
Competences
1.Understanding the basic principles of quantitative substance analysis and detection. Finding relationship between theoretical calculation and practical sample and reactant properties. Possibility of evaluating errors on the results obtained.
Assessment
Individual work
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Title
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% from total grade
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Grade
|
|---|---|---|
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1.
Individual work |
-
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-
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• Individual practical work in the laboratory of analytical chemistry and writing protocols;
• Literature research;
• Solving calculation tasks according to the course topics;
• Preparation for colloquiums and tests;
• Creating a description of a complicated instrumental analysis method and analysis of a scientific article by working in groups;
• Making a presentation on the methods of analysis of the chosen medicinal substance.
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Examination
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Title
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% from total grade
|
Grade
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|---|---|---|
|
1.
Examination |
-
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-
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• Colloquium grades, which are formed by the average value of the marks of the theory and calculation task parts;
• Evaluation of the scientific article analysis according to the established criteria;
• Evaluation of the independent work presentation, which includes a summary of the methods of qualitative and quantitative analysis of the medicinal substance;
• Evaluation of the accuracy of medicinal substances quantification during practical work and participation in seminars;
• Written examination on nature, application possibilities, and calculations of quantitative analysis methods, which is structurally identical to the colloquium.
The final grade of the course is calculated as follows: 50% exam mark + 25% average colloquium mark + 5% article analysis grade + 10% presentation grade + 10% average grade of participation in seminars and laboratory work results.
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Study Course Theme Plan
FULL-TIME
Part 1
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Class/Seminar
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Modality
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Location
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Contact hours
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|---|---|---|
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On site
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Laboratory
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4
|
Topics
|
Introductory lesson.
Workshop: introduction to quantitative analysis, measuring cups used in a laboratory, theoretical substantiation of titrimetry, and calculations.
Laboratory work: Measuring the volume of laboratory glassware
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-
Class/Seminar
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Modality
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Location
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Contact hours
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|---|---|---|
|
On site
|
Laboratory
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4
|
Topics
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Workshop: calculations in direct titration.
Laboratory work: acidimetry.
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-
Class/Seminar
|
Modality
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Location
|
Contact hours
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|---|---|---|
|
On site
|
Laboratory
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4
|
Topics
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Workshop: calculations in reverse titration.
Laboratory work: alkalimetry.
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-
Class/Seminar
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Modality
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Location
|
Contact hours
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|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
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Laboratory works: titration of weak bases in non-aqueous media; complexonometry
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-
Class/Seminar
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Modality
|
Location
|
Contact hours
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|---|---|---|
|
On site
|
Laboratory
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4
|
Topics
|
Colloquium: Fundamentals of quantitative analysis and titrimetry, protolitometry in aqueous and non-aqueous media, complexometry.
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-
Class/Seminar
|
Modality
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Location
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Contact hours
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|---|---|---|
|
On site
|
Laboratory
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4
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Topics
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Laboratory work: argentometry.
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-
Class/Seminar
|
Modality
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Location
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Contact hours
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|---|---|---|
|
On site
|
Laboratory
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4
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Topics
|
Workshop: calculations in replacement titration and control titration
Laboratory work: permanganatometry
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-
Class/Seminar
|
Modality
|
Location
|
Contact hours
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|---|---|---|
|
On site
|
Laboratory
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4
|
Topics
|
Laboratory work: iodometry.
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-
Class/Seminar
|
Modality
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Location
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Contact hours
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|---|---|---|
|
On site
|
Laboratory
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4
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Topics
|
Laboratory works: bromatometry, bromometry
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-
Class/Seminar
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Modality
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Location
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Contact hours
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|---|---|---|
|
On site
|
Auditorium
|
4
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Topics
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Workshop: calculations in gravimetric methods
Laboratory work: nitritometry.
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-
Class/Seminar
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Modality
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Location
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Contact hours
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|---|---|---|
|
On site
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Laboratory
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4
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Topics
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Colloquium: sedimetry, oxidimetry, gravimetry.
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-
Class/Seminar
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Modality
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Location
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Contact hours
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|---|---|---|
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On site
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Laboratory
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4
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Topics
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Workshop: calculation in refractometry
Laboratory work: potentiometry, refractometry
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-
Class/Seminar
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Modality
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Location
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Contact hours
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|---|---|---|
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On site
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Laboratory
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4
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Topics
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Workshop: calculations in spectrophotometry
Laboratory work: spectrophotometry
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-
Class/Seminar
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Modality
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Location
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Contact hours
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|---|---|---|
|
On site
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Laboratory
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4
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Topics
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Workshop: calcualtions in chromatography
Laboratory work: high-performance liquid chromatography (HPLC)
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-
Class/Seminar
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Modality
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Location
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Contact hours
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|---|---|---|
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On site
|
Laboratory
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4
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Topics
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Workshop: group presentations on methods of instrumental analysis
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-
Class/Seminar
|
Modality
|
Location
|
Contact hours
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|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Colloquium: methods of instrumental analysis.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
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|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
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Presentation of independent work - analysis of a selected medicinal substance.
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Total ECTS (Creditpoints):
6.00
Contact hours:
68 Academic Hours
Final Examination:
Exam (Written)
Bibliography
Required Reading
1.
G. D. Christian, P. K. Dasgupta, K. A. Schug. Analytical Chemistry. 7th Edition. John Wiley & Sons, Inc., USA, 2020.
Additional Reading
1.
D. C. Harris, C. A. Lucy. Quantitative Chemical Analysis. 10th edition. W. H. Freeman, New-York, 2020.
2.
D. A. Skoog, D. M. West, F. James Holler, S. R. Crouch. Fundamentals of Analytical Chemistry. 10th edition, Mary Finch, USA, 2022.
Other Information Sources
1.
E. Jansons. Analītiskās ķīmijas teorētiskie pamati. Rīga, 2006.
2.
Council of Europe, European Pharmacopoeia. 11th edition. Strasbourg: Council of Europe, 2024.