Veidlapa Nr. M-3 (8)
Study Course Description
Hemorrhagic Conditions and Thrombosis
Course Code
RHE_036
Branch of Science
Clinical medicine
ECTS
10.35
Target Audience
Medicine
LQF
Level 8
Study Course Implementer
Course Supervisor
Sandra Lejniece
Residency Speciality
Speciality
Hematologist
Supervisor of Medical Speciality
Sandra Lejniece
Contacts
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About Study Course
Objective
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Learning Outcomes
Knowledge
1.-
Skills
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Competences
1.-
Assessment
Individual work
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Examination |
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Study Course Theme Plan
FULL-TIME
Part 1
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Total ECTS (Creditpoints):
10.35
Number of Residency Seminars:
6
Length (weeks):
8
Final Examination:
Residency exam (Theory and practice)
Bibliography
Required Reading
1.
Middeldorp S. Inherited thrombophilia: a double-edged sword. Hematology Am Soc Hematol Educ Program. 2016 Dec 2;2016(1):1-9. doi: 10.1182/asheducation-2016.1.1. PMID: 27913455; PMCID: PMC6142488.
2.
Trasca LF, Patrascu N, Bruja R, Munteanu O, Cirstoiu M, Vinereanu D. Therapeutic Implications of Inherited Thrombophilia in Pregnancy. Am J Ther. 2019 May/Jun;26(3):e364-e374. doi: 10.1097/MJT.0000000000000985. PMID: 30985485.
3.
Campello E, Spiezia L, Adamo A, Simioni P. Thrombophilia, risk factors and prevention. Expert Rev Hematol. 2019 Mar;12(3):147-158. doi: 10.1080/17474086.2019.1583555. Epub 2019 Feb 26. PMID: 30773075.
4.
Armstrong EM, Bellone JM, Hornsby LB, Treadway S, Phillippe HM. Acquired Thrombophilia. J Pharm Pract. 2014 Jun;27(3):234-42. doi: 10.1177/0897190014530424. Epub 2014 Apr 17. PMID: 24742931.
5.
Montagnana M, Lippi G, Danese E. An Overview of Thrombophilia and Associated Laboratory Testing. Methods Mol Biol. 2017;1646:113-135. doi: 10.1007/978-1-4939-7196-1_9. PMID: 28804823.
6.
van Vlijmen EF, Wiewel-Verschueren S, Monster TB, Meijer K. Combined oral contraceptives, thrombophilia and the risk of venous thromboembolism: a systematic review and meta-analysis. J Thromb Haemost. 2016 Jul;14(7):1393-403. doi: 10.1111/jth.13349. Epub 2016 Jun 16. PMID: 27121914.
7.
Connors JM. Thrombophilia Testing and Venous Thrombosis. N Engl J Med. 2017 Sep 21;377(12):1177-1187. doi: 10.1056/NEJMra1700365. PMID: 28930509.
8.
Nathwani AC. Gene therapy for hemophilia. Hematology Am Soc Hematol Educ Program. 2019 Dec 6;2019(1):1-8. doi: 10.1182/hematology.2019000007. PMID: 31808868; PMCID: PMC6913446.
9.
Arruda VR, Doshi BS, Samelson-Jones BJ. Novel approaches to hemophilia therapy: successes and challenges. Blood. 2017 Nov 23;130(21):2251-2256. doi: 10.1182/blood-2017-08-742312. Epub 2017 Oct 10. Erratum in: Blood. 2018 Jun 28;131(26):2995. PMID: 29018078; PMCID: PMC5813735.
10.
Makris M, Oldenburg J, Mauser-Bunschoten EP, Peerlinck K, Castaman G, Fijnvandraat K; subcommittee on Factor VIII, Factor IX and Rare Bleeding Disorders. The definition, diagnosis and management of mild hemophilia A: communication from the SSC of the ISTH. J Thromb Haemost. 2018 Dec;16(12):2530-2533. doi: 10.1111/jth.14315. Epub 2018 Nov 15. PMID: 30430726
11.
Peters R, Harris T. Advances and innovations in haemophilia treatment. Nat Rev Drug Discov. 2018 Jul;17(7):493-508. doi: 10.1038/nrd.2018.70. Epub 2018 Jun 8. PMID: 29880919.
12.
Mingot-Castellano ME, Núñez R, Rodríguez-Martorell FJ. Acquired haemophilia: Epidemiology, clinical presentation, diagnosis and treatment. Med Clin (Barc). 2017 Apr 7;148(7):314-322. English, Spanish. doi: 10.1016/j.medcli.2016.11.030. Epub 2017 Jan 22. PMID: 28118963
13.
Calmette L, Clauser S. La maladie de Willebrand [Von Willebrand disease]. Rev Med Interne. 2018 Dec;39(12):918-924. French. doi: 10.1016/j.revmed.2018.08.005. Epub 2018 Sep 29. PMID: 30279008
14.
Sharma R, Flood VH. Advances in the diagnosis and treatment of Von Willebrand disease. Blood. 2017 Nov 30;130(22):2386-2391. doi: 10.1182/blood-2017-05-782029. PMID: 29187375; PMCID: PMC5709787
15.
Ng CJ, Di Paola J. von Willebrand Disease: Diagnostic Strategies and Treatment Options. Pediatr Clin North Am. 2018 Jun;65(3):527-541. doi: 10.1016/j.pcl.2018.02.004. PMID: 29803281
16.
Mondoloni M, Guyon A, Descroix V, Lescaille G. Purpura thrombopénique immunologique [Immune thrombocytopenic purpura]. Rev Prat. 2019 Mar;69(3):290. French. PMID: 30983256
17.
Marini I, Bakchoul T. Pathophysiology of Autoimmune Thrombocytopenia: Current Insight with a Focus on Thrombopoiesis. Hamostaseologie. 2019 Aug;39(3):227-237. doi: 10.1055/s-0039-1678732. Epub 2019 Feb 25. PMID: 30802916
18.
Hrdinová J, D'Angelo S, Graça NAG, Ercig B, Vanhoorelbeke K, Veyradier A, Voorberg J, Coppo P. Dissecting the pathophysiology of immune thrombotic thrombocytopenic purpura: interplay between genes and environmental triggers. Haematologica. 2018 Jul;103(7):1099-1109. doi: 10.3324/haematol.2016.151407. Epub 2018 Apr 19. PMID: 29674502; PMCID: PMC6029525
19.
Johnstone C, Rich SE. Bleeding in cancer patients and its treatment: a review. Ann Palliat Med. 2018 Apr;7(2):265-273. doi: 10.21037/apm.2017.11.01. Epub 2017 Dec 18. PMID: 29307210
20.
Boender J, Kruip MJ, Leebeek FW. A diagnostic approach to mild bleeding disorders. J Thromb Haemost. 2016 Aug;14(8):1507-16. doi: 10.1111/jth.13368. Epub 2016 Jun 27. PMID: 27208505
21.
Hayward CPM. How I investigate for bleeding disorders. Int J Lab Hematol. 2018 May;40 Suppl 1:6-14. doi: 10.1111/ijlh.12822. PMID: 29741250
22.
Franchini M, Marano G, Cruciani M, Mengoli C, Pati I, Masiello F, Veropalumbo E, Pupella S, Vaglio S, Liumbruno GM. Advances in managing rare acquired bleeding disorders. Expert Rev Hematol. 2020 Jun;13(6):599-606. doi: 10.1080/17474086.2020.1756259. Epub 2020 Apr 23. PMID: 32286895
23.
Menegatti M, Biguzzi E, Peyvandi F. Management of rare acquired bleeding disorders. Hematology Am Soc Hematol Educ Program. 2019 Dec 6;2019(1):80-87. doi: 10.1182/hematology.2019000066. PMID: 31808848; PMCID: PMC6913473
Additional Reading
1.
Cines DB, Bussel JB, Liebman HA, Luning Prak ET. The ITP syndrome: pathogenic and clinical diversity. Blood. 2009 Jun 25;113(26):6511-21. doi: 10.1182/blood-2009-01-129155. Epub 2009 Apr 24. PMID: 19395674; PMCID: PMC2710913
2.
Mannucci PM, Franchini M. The real value of thrombophilia markers in identifying patients at high risk of venous thromboembolism. Expert Rev Hematol. 2014 Dec;7(6):757-65. doi: 10.1586/17474086.2014.960385. Epub 2014 Sep 18. PMID: 25231393.
3.
Stevens SM, Woller SC, Bauer KA, Kasthuri R, Cushman M, Streiff M, Lim W, Douketis JD. Guidance for the evaluation and treatment of hereditary and acquired thrombophilia. J Thromb Thrombolysis. 2016 Jan;41(1):154-64. doi: 10.1007/s11239-015-1316-1. PMID: 26780744; PMCID: PMC4715840.
4.
Moll S. Thrombophilia: clinical-practical aspects. J Thromb Thrombolysis. 2015 Apr;39(3):367-78. doi: 10.1007/s11239-015-1197-3. PMID: 25724822
5.
Srivastava A, Brewer AK, Mauser-Bunschoten EP, Key NS, Kitchen S, Llinas A, Ludlam CA, Mahlangu JN, Mulder K, Poon MC, Street A; Treatment Guidelines Working Group on Behalf of The World Federation Of Hemophilia. Guidelines for the management of hemophilia. Haemophilia. 2013 Jan;19(1):e1-47. doi: 10.1111/j.1365-2516.2012.02909.x. Epub 2012 Jul 6. PMID: 22776238.
6.
Klamroth R. A new era of treatment for patients with haemophilia A? Hamostaseologie. 2017 Aug 8;37(3):216-218. doi: 10.5482/HAMO-16-07-0028. Epub 2016 Nov 25. PMID: 27885373