Veidlapa Nr. M-3 (8)
Study Course Description
Organic Chemistry
Course Code
LFK_018
Branch of Science
Basic medicine
ECTS
13.00
Target Audience
Pharmacy
LQF
Level 7
Study Type And Form
Full-Time; Part-Time
Study Course Implementer
Course Supervisor
Māra Plotniece
Structure Unit Manager
Baiba Mauriņa
Structural Unit
Department of Applied Pharmacy
Contacts
Riga, 21 Consula Street, lfk@rsu.lv, +371 67061547
About Study Course
Objective
Learn basic course of organic chemistry for further understanding of biochemistry, medical chemistry and pharmaceutical science.
Preliminary Knowledge
Knowledge of organic chemistry within the programme of secondary school, inorganic chemistry.
Learning Outcomes
Knowledge
1.On successful course completion students will: • identify functional groups of organic compounds and explain their properties and possibilities of mutual conversions; • interpret relations of special structures of molecules with their properties; • identify structures of heterocyclic compounds and their properties; • interpret reactions of organic compounds on the bases of the main principles of reaction mechanisms.
Skills
1.On successful course completion students will: • recognize functional groups in drug molecules, name them, know the chemical properties and identification reactions of the group; • select and apply correct methods for isolation and purification of organic compounds; • evaluate chemical structures of drug substances in connection with their pharmacological actions.
Competences
1.On successful course completion students will choose and interpret chemical and physical methods of identification and functional analysis of organic compounds.
Assessment
Individual work
|
Title
|
% from total grade
|
Grade
|
|---|---|---|
|
1.
Before the colloquium: repeating theory, performing self-checkout tasks |
-
|
-
|
|
2.
Before the workshop: Repeat lecture material |
-
|
-
|
|
3.
Before lab work: familiarize yourself with reagent safety pages, protocol preparation |
-
|
-
|
|
4.
After laboratory work: Design and submit a protocol |
-
|
-
|
Examination
|
Title
|
% from total grade
|
Grade
|
|---|---|---|
|
1.
share of colloquiums for both semesters |
50.00% from total grade
|
10 points
|
Final score [A + {(B + C): 2}): 2 = X + bonuses obtained in both semesters, maximum 0.5 + 0.5 = 1.0 |
||
|
2.
autumn semester test result |
25.00% from total grade
|
10 points
|
Final score [A + {(B + C): 2}): 2 = X + bonuses obtained in both semesters, maximum 0.5 + 0.5 = 1.0 |
||
|
3.
writing exam job mark |
25.00% from total grade
|
10 points
|
Final score [A + {(B + C): 2}): 2 = X + bonuses obtained in both semesters, maximum 0.5 + 0.5 = 1.0 |
||
|
4.
semester counting |
0.00% from total grade
|
Test
|
|
To receive a semester count, you must successfully pass the semester jobs (laboratory work completed, protocols credited, colloquiums successfully passed). |
||
|
5.
cumulative score |
0.00% from total grade
|
10 points
|
|
The student may not take the examination (i.e. there is a possibility to qualify for the accumulating assessment or “automatic examination”) if all colloquiums have been passed for at least 8.00 with the first time and the other course requirements have been fulfilled. PLUS bonuses at the final score (throughout the course): 1. Minutes of a maximum of 0,5 points have been submitted and drawn up in accordance with the regulations during the spring semester; 2. In the autumn semester, the identification of an unknown organic matter shall be maximum 0,5 points. |
||
Study Course Theme Plan
FULL-TIME
Part 1
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Basic of organic chemistry
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
3
|
Topics
|
Seminar: nomenclature of organic compounds. Test: nomenclature of organic compounds. Independent work: completing self-test tasks.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
3
|
Topics
|
Seminar: acidity and basicity of organic compounds, stereochemistry. Test: acidity and basicity of organic compounds, stereochemistry.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Hydrocarbons.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Hydrocarbons.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
3
|
Topics
|
Colloquium: Basic of organic chemistry
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
3
|
Topics
|
Practical work: chemical properties and identification reactions of hydrocarbons.
Seminar: chemical properties and identification reactions of hydrocarbons. Test: chemical properties and identification reactions of hydrocarbons.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
3
|
Topics
|
Practical work: chemical properties and identification reactions of hydrocarbons.
Seminar: chemical properties and identification reactions of hydrocarbons. Test: chemical properties and identification reactions of hydrocarbons.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Introduction to spectroscopy (IR un 1H NMR spectroscopy for identification of organic compounds)
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Organic halides, alcohols, phenols, ethers, sulfur containing compounds.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
3
|
Topics
|
Colloquium: hydrocarbons
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
3
|
Topics
|
Practical work and seminar: chemical properties and identification reactions of organic halides, alcohols, phenols, ethers, sulfur containing compounds
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
3
|
Topics
|
Colloquium: organic halides, alcohols, phenols, ethers, sulfur containing compounds.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Carbonylcompounds: Aldehydes and ketones
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
3
|
Topics
|
Practical work: chemical properties and identification reactions of aldehydes and ketones
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Amines, diazonium ions, azocompounds and other nitrogen containing compounds
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Amines, diazonium ions, azocompounds and other nitrogen containing compounds
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
3
|
Topics
|
Colloquium: aldehydes and ketones (carbonylcompounds).
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
3
|
Topics
|
Practical work: chemical properties and identification reactions of amines, diazonium ions and azocompounds.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
3
|
Topics
|
Seminar: chemical properties and identification reactions of amines, diazonium ions and azocompounds.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Carboxylic acids
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Carboxylic acid derivatives, different functional group containing carboxylic acids, derivatives of carbonic acid, sulfonic acids.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
3
|
Topics
|
Colloquium: amines, diazonium ions and azocompounds
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
3
|
Topics
|
Practical work: chemical properties and identification reactions of carboxylic acids and their derivatives. Seminar: chemical properties and identification reactions of carboxylic acids and their derivatives.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
3
|
Topics
|
Colloquium: carboxylic acids and their derivatives.
FINNAL TEST
|
Total ECTS (Creditpoints):
6.00
Contact hours:
65 Academic Hours
Final Examination:
Test (Semester)
Part 2
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
5
|
Topics
|
Laboratory work: methods for purifying organic compounds: re-crystallisation, fractional distillation, sublimation, extraction (individual tasks).
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Heterocycles
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
5
|
Topics
|
Practical work: Purification of organic com-pounds: crystallization, fractional distillation, sublimation, extraction.
Colloquium: Basic of organic chemistry.
Independent work: preparation of protocols, familiarization with reagent safety data sheets, repetition of material learned in the previous semester.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Heterocycles
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
5
|
Topics
|
Seminar: Heterocycles: clasification and no-menclature, heterocycles with one heteroatom, heterocycles with two heteroatoms, purine, pteridine, alkaloids, carbohydrates. Independent work: completing self-test tasks.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Carbohydrates
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
5
|
Topics
|
Practical work: Synthesis of organic compounds (individual work). Independent work: preparation of protocols, familiarization with reagent safety data sheets.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Carbohydrates
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
5
|
Topics
|
Laboratory work: synthesis, purification and analysis of organic preparations (individ tasks). Seminar: carbohydrates. Independent work: preparation of protocols, familiarity with reagent safety data sheets.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Aminoacids, peptides, nucleic acids
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
5
|
Topics
|
Practical work: Synthesis of organic compounds (individual work). Independent work: preparation of protocols, familiarization with reagent safety data sheets.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Lipids. Cholesterol.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
5
|
Topics
|
Practical work: Synthesis of organic compounds (individual work). Independent work: preparation of protocols, familiarization with reagent safety data sheets.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
5
|
Topics
|
Colloquium: Heterocycles, Carbohydrates. Independent work: completing self-test tasks.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
5
|
Topics
|
Practical work: Synthesis of organic compounds (individual work). Independent work: preparation of protocols, familiarization with reagent safety data sheets.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
5
|
Topics
|
Seminar: Aminoacids, peptides, nucleic acids, lipids. Independent work: analysis of lecture material, completion of self-test tasks.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
5
|
Topics
|
Practical work: Identification of organic compound using chemical and spectroscopic methods.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
5
|
Topics
|
Colloquium: amino acids, peptides, nucleic acids, lipids. Laboratory work: control analysis: demonstrating the structure of an unknown organic matter using chemical and spectroscopic methods.
|
Total ECTS (Creditpoints):
7.00
Contact hours:
72 Academic Hours
Final Examination:
Exam (Written)
PART-TIME
Part 1
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
4
|
Topics
|
Basic of organic chemistry
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
4
|
Topics
|
Hydrocarbons.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
4
|
Topics
|
Hydrocarbons.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Practical work: chemical properties and identification reactions of hydrocarbons.
Seminar: chemical properties and identification reactions of hydrocarbons. Test: chemical properties and identification reactions of hydrocarbons.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
4
|
Topics
|
Organic halides, alcohols, phenols, ethers, sulfur containing compounds.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Colloquium: hydrocarbons
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Practical work and seminar: chemical properties and identification reactions of organic halides, alcohols, phenols, ethers, sulfur containing compounds
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Colloquium: organic halides, alcohols, phenols, ethers, sulfur containing compounds.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
4
|
Topics
|
Carbonylcompounds: Aldehydes and ketones
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
4
|
Topics
|
Amines, diazonium ions, azocompounds and other nitrogen containing compounds
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Colloquium: aldehydes and ketones (carbonylcompounds).
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Practical work: chemical properties and identification reactions of amines, diazonium ions and azocompounds.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Seminar: chemical properties and identification reactions of amines, diazonium ions and azocompounds.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
4
|
Topics
|
Carboxylic acids
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
4
|
Topics
|
Dicarboxylic acids
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
4
|
Topics
|
Carboxylic acid derivatives, different functional group containing carboxylic acids, derivatives of carbonic acid, sulfonic acids.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Colloquium: carboxylic acids and their derivatives.
FINNAL TEST
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
4
|
Topics
|
Heterocycles
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Test: Heterocycles, Carbohydrates. Independent work: completing self-test tasks.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Seminar: Heterocycles: clasification and no-menclature, heterocycles with one heteroatom, heterocycles with two heteroatoms, purine, pteridine, alkaloids, carbohydrates. Independent work: completing self-test tasks.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
4
|
Topics
|
Carbohydrates
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
4
|
Topics
|
Aminoacids, peptides, nucleic acids
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
4
|
Topics
|
Lipids. Cholesterol.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
4
|
Topics
|
Lipids. Cholesterol.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Colloquium: Aminoacids, peptides, nucleic acids. Control analysis: Proving the structure of an unknown organic substance using chemical and spectroscopic methods. Independent work: completing self-test tasks.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Colloquium: Aminoacids, peptides, nucleic acids. Control analysis: Proving the structure of an unknown organic substance using chemical and spectroscopic methods. Independent work: completing self-test tasks.
|
Total ECTS (Creditpoints):
13.00
Contact hours:
112 Academic Hours
Final Examination:
Exam (Written)
Bibliography
Required Reading
1.
P.M. Dewick. Essentiasl of Organic Chemistry. John Wiley & Son’s, England, 2006. (akceptējams izdevums)
2.
K.P.C. Vollhardt, N.E. Shore. Organic Chemistry: Structure and Function. 7th ed. New York, N.Y. : W.H. Freeman and Company, 2014.
3.
Органическая химия. Книга 1. Подред. Н.А. Тюкавкиной. М. 2003. (akceptējams izdevums)
4.
Органическая химия. Книга 2.Спец.курсс. Подред. Н.А. Тюкавкиной. М. 2009. (akceptējams izdevums)
5.
T.W. Graham Solomons. Solomons' Organic Chemistry. University of South Florida, 2017.
Additional Reading
1.
R. Valters. Organiskā ķīmija (speckurss). RTU Rīga, 2009
2.
R. Valters. Heterociklisko savienojumu ķīmija. RTU Rīga, 1995.
3.
R. Valters. Kodolu magnētiskās rezonanses spektroskopija. RTU Rīga, 2008.
4.
V. Alagarsamy. Pharmaceutical Organic Chemistry. BSP BOOKS, 2020, e-book.
5.
Rawn, J. David; Ouellette, Robert J. Organic Chemistry: structure, mechanism, and synthesis. 1st ed. San Diego, CA : Elsevier. 2014. eBook.
6.
Тюкавкина Н.А. Бауков Ю.И. Биоорганическая химия. М. 1991.
7.
Armarego, W. L. F.; Chai, Christina Li Lin. Purification of laboratory chemicals. 6th ed. Oxford : Butterworth-Heinemann. 2012. eBook.
8.
Ārvalstu studentiem/For international students
9.
V. Alagarsamy. Pharmaceutical Organic Chemistry. BSP BOOKS, 2020, e-book.
10.
Armarego, W. L. F.; Chai, Christina Li Lin. Purification of laboratory chemicals. 6th ed. Oxford : Butterworth-Heinemann. 2012. eBook.