Veidlapa Nr. M-3 (8)
Study Course Description
Immunology and Immunopharmacology
Course Code
BUMK_081
Branch of Science
Clinical medicine
ECTS
2.00
Target Audience
Pharmacy
LQF
Level 7
Study Type And Form
Full-Time
Study Course Implementer
Course Supervisor
Ingus Skadiņš
Structure Unit Manager
Juta Kroiča
Structural Unit
Department of Biology and Microbiology
Contacts
Riga, 16 Dzirciema Street, bmk@rsu.lv, +371 67061584
About Study Course
Objective
Provide knowledge of innate organism resistance, mechanisms of resistance. Provide knowledge of the body’s immune system, immune cells, cytokines, signal transmission and cell activation. The types and mechanisms of the immune response. The importance of humorous and cellular immunity to bacterial, viral, immunoglobulins, their classes and their importance. Provide knowledge of immune pathology, hypersensitivity reactions, their mechanisms. Provide knowledge of immunisations, types of vaccines, mechanisms for their operation. Provide knowledge of serodiagnostics, types of serological responses, molecular diagnostic methods, their operating principles.
Preliminary Knowledge
In biology, anatomy, histology, biochemistry, microbiology.
Learning Outcomes
Knowledge
1.After completing the study course, students will be able to describe micro-organisms and the most relevant human parasites, describe their prevalence in the environment, understand and explain their pathogenicity and role in the origin of infectious diseases and interaction processes with macro-organisms.
Skills
1.As a result of completing the study course, students will be able: • to evaluate the aetiology of illnesses, sources of infection, transmission routes, pathogenesis, epidemiological hazard, prevention.
Competences
1.By combining theoretical knowledge with practical skills, students will have the opportunity to apply them in the form of a unified integrative understanding of the importance of bacterial and viral pathogenicity factors in the aetiology of the disease, and will be able to apply them to the mechanisms of pathogenesis and interaction with the host organism.
Assessment
Individual work
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Title
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% from total grade
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Grade
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|---|---|---|
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1.
Individual work |
-
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-
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Students will independently prepare presentations for seminars on the immune response and hypersensitivity reactions, current agents of infectious diseases.
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Examination
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Title
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% from total grade
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Grade
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|---|---|---|
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1.
Examination |
-
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10 points
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• regular attendance of classes, active participation in practical classes; • successful completion of weekly tests and semester colloquia; • assessment of independent learning; • cumulative exam at the end of the study course, fulfilling all criteria. Detailed information in e-studies. |
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Study Course Theme Plan
FULL-TIME
Part 1
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Class/Seminar
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Modality
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Location
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Contact hours
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|---|---|---|
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On site
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Study room
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2
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Topics
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Types of interaction between micro-organisms and macro-organisms. Bacterial pathogenicity factors, their role in the infection process. Characterisation of the infection process. Transmission of infection.
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-
Class/Seminar
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Modality
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Location
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Contact hours
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|---|---|---|
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On site
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Study room
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2
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Topics
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Non-specific resistance of the body – general and cellular factors – phagocytosis, inflammation, TLR receptors – their meaning, mechanisms of action. Humorous factors of the body’s innate immunity – complement system, activation pathways, role in activation of acquired immunity.
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-
Class/Seminar
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Modality
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Location
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Contact hours
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|---|---|---|
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On site
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Study room
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2
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Topics
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Antigens, types, breakdown, properties. Antigen design. MHC – Class I and II antigens, characteristics, their properties and their role in activating the immune response. Antibodies, characteristics, properties, functions. Primary and secondary structure of antibodies. The role of immunoglobulins, their class, in the immune response.
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-
Class/Seminar
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Modality
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Location
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Contact hours
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|---|---|---|
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On site
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Study room
|
2
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Topics
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T lymphocytes, their histogenesis, characteristics and properties. T lymphocyte subpopulations, their role in adaptive immunity. Activation of T lymphocytes. Antigen-presenting cells – B lymphocytes, macrophages, their differentiation and role in an immune response. B lymphocyte activation and antibody production. Primary and secondary humoral immune response. Cytokines.
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Class/Seminar
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Modality
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Location
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Contact hours
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|---|---|---|
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On site
|
Study room
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2
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Topics
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Principles of microbiological and serological diagnosis of infectious diseases. Immune serums. Diagnosticums. Types of agglutination reactions. Reactions labeled AG and AV, ELISA, immunofluorescence, PCR.
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Class/Seminar
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Modality
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Location
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Contact hours
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|---|---|---|
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On site
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Study room
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2
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Topics
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Cellular immunity, mechanism of action. NK cells. Antiviral immunity. Anti-toxic, anti-mushroom, anti-apsular immune response, their mechanisms of action, outcomes and role in pathogenesis of various infectious diseases.
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Class/Seminar
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Modality
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Location
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Contact hours
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|---|---|---|
|
On site
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Study room
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2
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Topics
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Hypersensitivity, characterisation, types of reactions and mechanisms of action. Allergens, their characterisation and breakdown. Vaccines
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Video Lecture
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Modality
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Location
|
Contact hours
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|---|---|---|
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Off site
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E-Studies platform
|
2
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Topics
|
Types of interaction between micro-organisms and macro-organisms. Bacterial pathogenicity factors, their role in the infection process. Characterisation of the infection process. Transmission of infection. Non-specific resistance of the body – general and cellular factors – phagocytosis, inflammation, TLR receptors – their meaning, mechanisms of action. Humorous factors of the body’s innate immunity – complement system, activation pathways, role in activation of acquired immunity.
|
-
Video Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
Off site
|
E-Studies platform
|
2
|
Topics
|
Antigens, types, breakdown, properties. Antigen design. MHC – Class I and II antigens, characteristics, their properties and their role in activating the immune response. Antibodies, characteristics, properties, functions. Primary and secondary structure of antibodies. The role of immunoglobulins, their class, in the immune response.
|
-
Video Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
Off site
|
-
|
2
|
Topics
|
T lymphocytes, their histogenesis, characteristics and properties. T lymphocyte subpopulations, their role in adaptive immunity. Activation of T lymphocytes. Antigen-presenting cells – B lymphocytes, macrophages, their differentiation and role in an immune response. B lymphocyte activation and antibody production. Primary and secondary humoral immune response. Cytokines.
|
-
Video Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
Off site
|
E-Studies platform
|
2
|
Topics
|
Cellular immunity, mechanism of action. NK cells. Antiviral immunity. Anti-toxic, anti-mushroom, anti-apsular immune response, their mechanisms of action, outcomes and role in pathogenesis of various infectious diseases.
|
-
Video Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
Off site
|
-
|
2
|
Topics
|
Hypersensitivity, characterisation, types of reactions and mechanisms of action. Allergens, their characterisation and breakdown. Vaccines
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Total ECTS (Creditpoints):
2.00
Contact hours:
24 Academic Hours
Final Examination:
Exam
Bibliography
Required Reading
1.
Jawetz, Melnick, & Adelberg's Medical Microbiology. 28th ed., 2019.Suitable for English stream
2.
P. Murray, et al. Medical Microbiology. 8th ed. 2021.Suitable for English stream
Additional Reading
1.
Review of Medical Microbiology and Immunology. 17th ed., 2021Suitable for English stream
2.
Aija Žileviča, Ivars Mazjānis. Medicīnas mikrobioloģija. Vispārīgā mikrobioloģija un infekcijas imunoloģija. Latvijas Universitātes akadēmiskais apgāds; 2014
Other Information Sources
1.
E-studijas