Veidlapa Nr. M-3 (8)
Study Course Description
Pharmacogenetics
Course Code
LFK_001
Branch of Science
Basic medicine
ECTS
3.00
Target Audience
Pharmacy
LQF
Level 7
Study Type And Form
Full-Time; Part-Time
Study Course Implementer
Course Supervisor
Renāte Ranka
Structure Unit Manager
Baiba Mauriņa
Structural Unit
Department of Applied Pharmacy
Contacts
Riga, 21 Consula Street, farmkk@rsu.lv, +371 67061544
About Study Course
Objective
To introduce students to the basic concepts of pharmacogenetics, research methods and the application of pharmacogenetics tests in modern health care.
Preliminary Knowledge
In biology, pharmacology and human genetics.
Learning Outcomes
Knowledge
1.As a result of completing the study course, students acquire basic knowledge in the theory of pharmacogenetics, i.e. what is pharmacogenetics, what are the types and goals of pharmacogenetics research, how the characteristics of the human genome can affect the effect of medicinal products on the patient’s body and how medical personnel could predict these effects.
Skills
1.As a result of completing the study course, students acquire skills in evaluating the influence of heredity factors in cases of variations in drug action and the ability to search for a solution to the situation. Will be able to explain social and clinical perspectives on interindividual variability in responses to drug substances.
Competences
1.As a result of completing the study course, students gain competence in issues related to the application of human genome research for the provision of personalised pharmacotherapy and the creation of new pharmacogenetic tests, as well as ethical aspects of pharmacogenetics.
Assessment
Individual work
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Title
|
% from total grade
|
Grade
|
|---|---|---|
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1.
Individual work |
-
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-
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|
Within the course, the student prepares an independent work using scientific literature (books and scientific publications) in the form of a course work, which is presented in the seminar.
Students must fill in the study course evaluation questionnaires.
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Examination
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Title
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% from total grade
|
Grade
|
|---|---|---|
|
1.
Examination |
-
|
-
|
|
The student understands the basic mechanisms of drug effects and side effects, which are related to human genetics. The student is familiar with the basic concepts and basic methods of the subject, knows examples of hereditary variations in the genes of various drug metabolism enzymes and their effect on drug metabolism, knows how to justify with concrete examples the effect of variations in the genes of drug receptors and transport proteins on the effect of drugs.
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Study Course Theme Plan
FULL-TIME
Part 1
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Introduction into pharmacogenetics
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Human genetics
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Pharmacogenetics of drug metabolising enzymes 1
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Pharmacogenetics of drug metabolising enzymes 2
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Pharmacogenetics of drug metabolising enzymes 3
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Cytochrome P450
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Pharmacogenetics of drug targets
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Research in pharmacogenetics
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
Introduction into pharmacogenetics
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
Human genetics
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
Pharmacogenetics of drug metabolizing enzymes 1
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
Pharmacogenetics of drug metabolizing enzymes 2
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
Pharmacogenetics of drug metabolizing enzymes 3
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
Cytochrome P450
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
Pharmacogenetics of drug targets
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
Research in pharmacogenetics
|
Total ECTS (Creditpoints):
3.00
Contact hours:
32 Academic Hours
Final Examination:
Exam (Written)
PART-TIME
Part 1
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Introduction into pharmacogenetics
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Human genetics
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Pharmacogenetics of drug metabolising enzymes 1
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Pharmacogenetics of drug metabolising enzymes 2
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Pharmacogenetics of drug metabolising enzymes 3
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Cytochrome P450
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Pharmacogenetics of drug targets
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Research in pharmacogenetics
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Introduction into pharmacogenetics
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Human genetics
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Pharmacogenetics of drug metabolizing enzymes 1
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Pharmacogenetics of drug metabolizing enzymes 2
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Pharmacogenetics of drug metabolizing enzymes 3
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Cytochrome P450
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Pharmacogenetics of drug targets
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Research in pharmacogenetics
|
Total ECTS (Creditpoints):
3.00
Contact hours:
32 Academic Hours
Final Examination:
Exam (Written)
Bibliography
Required Reading
1.
Clinical Applications of Pharmacogenetics. Edited by Despina Sanoudou. Publisher: InTech, 2012. DOI: 10.5772/1277 (Open Access book). (akceptējams izdevums)
2.
Pharmacogenetics. Wendell W. Weber. Oxford Monographs on Medical Genetics, 2nd edition, 2008. (akceptējams izdevums)
Additional Reading
1.
Pharmacogenomics: Social, Ethical, and Clinical Dimensions. Mark A. Rothstein.Wiley-Liss, 2003.
2.
Biochemistry. D.Voet, J.Voet. Wiley, 2021.
3.
Molecular Biology of the Cell. B.Alberts. Garland, 2015.
Other Information Sources
1.
PubMed datu bāze.