Veidlapa Nr. M-3 (8)
Study Course Description
Actualities in the Diagnosis and Treatment of Oncological and Hematological Diseases - Immunological, Genetic and Pathomorphological Aspects
Course Code
ISK_229
Branch of Science
Clinical medicine; Internal medicine
ECTS
3.00
Target Audience
Medicine
LQF
Level 7
Study Type And Form
Full-Time
Study Course Implementer
Course Supervisor
Sandra Lejniece
Structure Unit Manager
Jūlija Voicehovska
Structural Unit
Department of Internal Diseases
Contacts
Riga, 4 Hipokrata Street, isk@rsu.lv, +371 67042138
About Study Course
Objective
• Promote the acquisition of knowledge of haematological syndromes, their pathogenesis and clinical manifestations. Help to raise students’ awareness of the laboratory tests in addition to the examination methods that are used in cases of haematological syndromes. Learn the principles of differential diagnosis and investigation options of haematological syndromes.
• Promote and raise awareness of oncological diseases as a major public health problem that can be controlled.
• Contribute to the knowledge of modern biology and pathogenesis of tumours, of cancer statistics and global trends in cancer incidence and mortality.
• Acquire knowledge of the principles of cancer screening and early diagnostics and early disease prevalence assessment.
• Learn basic principles for diagnosis and treatment of breast, colon and rectum malignancies.
• Learn the diagnosis and treatment of oncological emergencies.
• Learn the pathogenesis of chronic pain syndrome in oncology.
Preliminary Knowledge
Scheme of hematopoiesis, division and maturation of blood cells. Changes in blood tests, their causes. Pathogenesis of hematological diseases, clinical manifestations, diagnostic and therapeutic principles.
Knowledge in biology, epidemiology, clinical pharmacology, microbiology, histology, anatomy, propaedetics, genetics, knowledge of the national language.
Learning Outcomes
Knowledge
1.On successful completion of the course, students will have gained knowledge of the epidemiology of the malignant diseases – incidence, prevalence, mortality, survival, first year lethality, common risk factors and prophylaxis of cancer. Students will learn about endocrine pathologies which develop from diagnostic and treatment procedures of malignant diseases, the latest radiological, morphological diagnostic options; differential diagnosis and treatment options for lung and breast cancer, as well as side effects of systemic therapy and treatment.
Skills
1.Upon completion of the study course, students will be able to analyse various epidemiological indicators of oncological diseases, to identify endocrine complications of such diseases and to explain the results of radiological examinations. Students will be able to recognise various lung diseases, assign appropriate examinations, and make the differential diagnosis. Students will be able to recognise various side effects of systemic treatment, assign proper laboratory tests and treatment.
Competences
1.On successful completion of the course, students will be able to draw up an investigation plan for haematological diseases, explain laboratory and other additional examination results, differentiate the changes and identify the most common haematological diseases. As a result of the study course, students will be able to analyse various epidemiological indicators of oncological diseases. Will be able to set the diagnosis and select additional diagnostic examination for lung and breast cancer. Students will be able to explain to the patient the side effects of systemic treatment and assign the appropriate treatment.
Assessment
Individual work
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Title
|
% from total grade
|
Grade
|
|---|---|---|
|
1.
Individual work |
-
|
-
|
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Individual work with literature on a specific topic. Analysis of epidemiological indicators for oncological diseases and presentation of the results.
Individual work with patients – taking anamnesis, interpretation of blood tests and radiological examinations. Setting of diagnosis and differential diagnosis, recognition of side effects of systemic treatment, drawing up an examination and treatment plan.
In order to evaluate the quality of the study course as a whole, the student must fill out the study course evaluation questionnaire on the Student Portal.
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Examination
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Title
|
% from total grade
|
Grade
|
|---|---|---|
|
1.
Examination |
-
|
-
|
|
1. Tests during classes.
2. Clinical case studies in classes.
3. A written test (75% of the test questions must be correct).
Each student reports on patients with a variety of haematological and oncological diseases, demonstrating the ability to communicate with a cancer patient, obtain targeted medical, life and family history, evaluate and criticise errors in patient care hitherto, interpret various differential diagnostic options, and justify therapeutic appropriateness to the relevant clinical situation.
A written test to check students' knowledge of haematological disease and tumour epidemiology, diagnostics and therapeutic options.
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Study Course Theme Plan
FULL-TIME
Part 1
-
Lecture
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Modality
|
Location
|
Contact hours
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|---|---|---|
|
On site
|
Specialized room
|
2
|
Topics
|
Guidelines and innovations in tissue examination in oncology.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Specialized room
|
2
|
Topics
|
Basic principles of differential diagnosis and therapy of lung malignancies.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Specialized room
|
2
|
Topics
|
Endocrine pathologies caused by diagnosis and therapy of oncological diseases.
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-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Specialized room
|
2
|
Topics
|
The role of diagnostic radiology in diagnosis of oncological diseases.
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-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Specialized room
|
3
|
Topics
|
Basic principles for breast cancer diagnosis and therapy.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Specialized room
|
3
|
Topics
|
Epidemiology of malignant tumors.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
3
|
Topics
|
Malignant tumors of the colon and rectum - etiology, diagnosis and treatment.
|
Total ECTS (Creditpoints):
1.50
Contact hours:
17 Academic Hours
Final Examination:
Test (Semester)
Part 2
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Specialized room
|
3
|
Topics
|
Comparison of different genetic testing methods and their application in oncohematology.
An insight into the guidelines for the interpretation of genetic variants, the most frequently used databases that are used for the interpretation of genetic variants (e.g. COSMIC, IARC TP53, ClinVar, etc.)
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-
Class/Seminar
|
Modality
|
Location
|
Contact hours
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|---|---|---|
|
On site
|
Specialized room
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3
|
Topics
|
Tumor immunology
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Specialized room
|
3
|
Topics
|
Monoclonal antibodies in oncology and hematology
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Specialized room
|
3
|
Topics
|
Basic principles of pathomorphological tissue processing and diagnostics
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-
Class/Seminar
|
Modality
|
Location
|
Contact hours
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|---|---|---|
|
On site
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Specialized room
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3
|
Topics
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CAR-T cells in oncology and hematology
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Total ECTS (Creditpoints):
1.50
Contact hours:
15 Academic Hours
Final Examination:
Exam
Bibliography
Required Reading
1.
Klīniskā medicīna prof. A.Lejnieka redakcijā. Medicīnas Apgāds, 785-914, 2010 (akceptējams izdevums)
2.
S.Lejniece. Klīniskā hematoloģija. Nacionālais Medicīnas Apgāds, 2020.
3.
A.Rivkina. Plūsmas citometrijas metode hematoloģisko slimību diagnostikā. 2019. SIA “Medicīnas apgāds”, 72-89.
4.
S.Lejniece, A.Lejnieks, B.Janicka-Kupra. Dzelzs deficīts. Absolūts vai funkcionāls? Medicīnas Apgāds, 2018.
5.
S.Lejniece. Dzelzs deficīta anēmija. Medicīnas Apgāds, 2015.
6.
Klīnisko analīžu rokasgrāmata. E.Gulbja laboratorija. Izdevējs E.Gulbja laboratorija, 2018.
7.
Conn's Current Therapy. Kellerman, Rick D., Rakel, David P. 2023. by Elsevier Inc
8.
The Merck manual of diagnosis and therapy. 12th Edition, Centennial Edition, 2018
9.
Hoffbrand ‘s Essential Haematology. 8th edition. A.V.Hoffbrand, P.A.H.Moss. Wiley-Blackwell, 2020.
10.
Ļaundabīgo audzēju TNM klasifikācija. Medicīnas apgāds, 2011. (akceptējams izdevums)
11.
Izdales materiāli nodarbībās.
12.
Klīniskā onkoloģija//Autoru kolektīvs D.Baltiņas vadībā. Zvaigzne ABC, 1999. (akceptējams izdevums)
13.
Lietišķā epidemioloģija//M.Baltiņš, Zinātne, 2003. (akceptējams izdevums)
14.
Diagnoze – vēzi. D.Baltiņa, Zinātne, 2009. (akceptējams izdevums)
15.
Klīniskās vadlīnijas onkoloģijā. Latvijas Onkologu ķīmijterapeitu asociācija, 2012 (akceptējams izdevums)
16.
DeVita, Hellman, and Rosenberg's Cancer Principles & Practice of Oncology. 11th edition, 2019
17.
gco.iarc.fr/databases.php
18.
who.int/health-topics/cancer#tab=tab_1
19.
Ārvalstu studentiem/For International students:
20.
Conn's Current Therapy. Kellerman, Rick D., Rakel, David P. 2023. by Elsevier Inc
21.
The Merck manual of diagnosis and therapy. 12th Edition, Centennial Edition, 2018
22.
Hoffbrand ‘s Essential Haematology. 8th edition. A.V.Hoffbrand, P.A.H.Moss. Wiley-Blackwell, 2020.
23.
DeVita, Hellman, and Rosenberg's Cancer Principles & Practice of Oncology. 11th edition, 2019
Additional Reading
1.
Hoffbrand's Essential Haematology (Essentials). 7th Edition by A. Victor Hoffbrand and Paul A. H. Moss, Willey Blackwell, 2020.
2.
Postgraduate Haematology by A. Victor Hoffbrand and Douglas R. Higgs, 2016.
3.
Haematology: A Core Curriculum. 1st Edition by Barbara Jane Bain, 2020
4.
Blood Cells: A Practical Guide. by Barbara J. Bain. 5th Edition, Wiley Blackwell, 2015.
5.
Dacie and Lewis Practical Haematology E-Book 12th Edition, Kindle Edition by Barbara J. Bain, Imelda Bates, Mike A Laffan, 2017.
6.
Practical transfusion medicine. Michael F. Murphy, David J Roberts, Mark H Yazer Hoboken, NJ: John & Sons Inc., 2017.
7.
Global Hematology by David J Roberts; D J Weatherall, Elservier, 2016.
8.
Cancer, Principles & Practice of Oncology, 7th ed. on CD-ROM [elektroniskais resurss] / [edited by Vincent T.] DeVita, [Samuel] Hellman, [Steven A.] Rosenberg. - [Philadelphia?]: Lippincott Williams & Wilkins, 2005. šifrs: 616-006.6(07)(0.034.4)/
9.
Jim Cassidy, Roy A., J. Spence (2015) Oxford handbook of Oncology. 4th edition, Oxford University press, UK
10.
Rudolph M.Navari, Bernardo L. Rapaport (2016) Fast Facts: Chemotherapy-Induced Nausea and Vomiting, Heatlh Press, Oxford, UK
11.
Matti S. Aapro, Katrin Jordan, Petra Feyer, Springer Healthcare (2011) Pocket books for cancer supportive care. Prevention of Nausea and Vomiting in Cancer patients, Springer Healthcare, USA
12.
Stephen T.Sonis (2011) Pocket books for cancer supportive care. Oral mucositis, Springer Healthcare, USA
Other Information Sources
1.
ASH mājas lapa
2.
EHA mājas lapa
3.
Medscape vietne
4.
Clinicalkey.com datu bāze
5.
spkc.gov.lv
6.
vmnvd.gov.lv
7.
UpToDate datu bāze
8.
gco.iarc.fr/databases.php
9.
who.int/health-topics/cancer#tab=tab_1
10.
Ārvalstu studentiem/For International students:
11.
UpToDate database
12.
who.int/health-topics/cancer#tab=tab_1
13.
gco.iarc.fr/databases.php