Veidlapa Nr. M-3 (8)
Study Course Description
Forensic Toxicology
Course Code
RTM_022
Branch of Science
Clinical medicine; Forensic science
ECTS
6.00
Target Audience
Medicine
LQF
Level 8
Study Course Implementer
Course Supervisor
Ojārs Teteris
Residency Speciality
Speciality
Forensic medicine expert
Supervisor of Medical Speciality
Ojārs Teteris
Contacts
-
About Study Course
Objective
To provide and deepen the basic knowledge in forensic chemistry and toxicology necessary for forensic medicine residents in order to prepare the forensic medicine resident for certification and independent work in the specialty of forensic medical research of living and dead persons.
Learning Outcomes
Knowledge
1.Knowledge of forensic toxicology, outline the technology used in it, correct sample collection and define toxic substances.
Skills
1.Remove, package and send samples of biological origin for forensic toxicological examination from living and dead persons (at least 300 cadaver examinations in all study years), determine the occurrence of death from poisoning, correctly interpret the results of laboratory examinations in forensic medical examinations of living persons and corpses.
Competences
1.Independently carry out the examination of the corpse and the medical examination of the corpse in cases of poisoning.
Assessment
Individual work
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Title
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% from total grade
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Grade
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|---|---|---|
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1.
Individual work |
-
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-
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Familiarize yourself with the latest literature in forensic toxicology, prepare a presentation on one of the topics of the seminar.
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Examination
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Title
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% from total grade
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Grade
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|---|---|---|
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1.
Examination |
-
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-
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Testing of theoretical knowledge with the help of a multiple-choice test, assessment of practical skills with a situational task. Assessment of knowledge in a 10-point system.
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Study Course Theme Plan
FULL-TIME
Part 1
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Seminar
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Modality
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Location
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-
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-
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Topics
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Poisoning by combustion products. Gas poisoning (propane-butane, methane, etc.). Sampling
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Seminar
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Modality
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Location
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|---|---|---|
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On site
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Study trip
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Topics
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Methods and technologies of toxicological investigation, their possibilities for the interpretation of death from poisoning.
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Seminar
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Modality
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Location
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-
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-
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Topics
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Poisoning with narcotic and psychotropic substances. Drug poisoning.
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Seminar
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Modality
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Location
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-
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-
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Topics
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Poisoning with metals, corrosive substances, technical liquids (ethylene glycol, gasoline, etc.), alcohol substitutes. Lethal concentration and dose. Metabolites.
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Placement
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Modality
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Location
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|---|---|---|
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On site
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Study trip
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Topics
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Special requirements for medical laboratories. Requirements of standard LVS EN ISO /IEC 15189 and 17025.
Recommendations of the International Association of Forensic Toxicologists (TIAFT) and the United Nations Drug Control Program (UNODC).
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Placement
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Modality
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Location
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|---|---|---|
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On site
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Study trip
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Topics
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Classical and modern methods of isolating toxic substances (A. Vasiljevas, V. Kramarenko, Stas-Otto, Kippenberger, Sunshine, Valov, Koppanyi, "trypsin method", distillation, deflegmation. Sample preparation for enzymatic immunoanalysis. Enzymatic immunomethods (EMIT, FPIA , ELISA, etc.) Dialysis Mineralization and destruction.
Effect of decomposition products of cadaveric material on methods of detection of injes.
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Placement
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Modality
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Location
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|---|---|---|
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On site
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Study trip
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Topics
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Determination of ethyl alcohol, its substitutes and other volatile substances. Vidmark's formula. Ethylene glycol, etc. glycols, cellosolves; Aromatic hydrocarbons; Methods of isolation of volatile substances and analysis by gas chromatography method. Cyanide determination methods;
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Placement
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Modality
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Location
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|---|---|---|
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On site
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Study trip
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Topics
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Toxic gases. Carbon monoxide. Carboxyhemoglobin and carboxy-myoglobin. Methods for determining carboxyhemoglobin (color reactions,
UV-spectrophotometry, gas chromatography). Analysis of other toxic gases.
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Placement
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Modality
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Location
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|---|---|---|
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On site
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Study trip
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Topics
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Modern chromatography methods (HPLC, GC-MS, LC-MS, capillary electrophoresis, etc.)
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Placement
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Modality
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Location
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|---|---|---|
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On site
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Study trip
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Topics
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Mass spectrometry technique and interpretation of mass spectra.
Analysis of ion spectra. Derivatization technique and derivatization reagents.
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Total ECTS (Creditpoints):
6.00
Number of Residency Seminars:
4
Length (weeks):
4
Final Examination:
Residency exam (Theory and practice)
Bibliography
Required Reading
1.
B.S.Levine, S.Kerrigan. Principles of Forensic Toxicology, 5e, 2020.
2.
R.J.Flanagan, Fundamentals of Analytical Toxicology: Clinical and Forensic, 2e, 2020
3.
J.P.Wyatt, T.Squires, G. Norfolk, J. Payne-James, Oxford Handbook of Forensic Medicine, Oxford Medical Handbooks, 2011
4.
Tiesu medicīnas praktikums, Rīga, RSU, 2007.
5.
O.Teteris. Tiesu medicīnas esence. R.,Rasa ABC, 2004, 591 lpp
6.
Vielas kā noziedzīgu nodarījumu pēdas. Rīga, LPA, 2007
7.
Dolinak D., Matshes E., Lew E. Forensic Pathology, Elsevier Acad. Press, 2005
Additional Reading
1.
Paškova V.I.,Tomiļin V.V. Laboratoriskās un speciālās izmeklēšanas metodes tiesu medicīnā,Maskava,Medicina,1975,455 lpp (kr.val.)
2.
Zaslavskis, Popovs, Šilovs V. Akūta saindēšanās ar etilalkoholu, St.Pēterburga, Juridiskais preses centrs, 2007 (kr.val.)
3.
Dmitrijeva, Zaslavskis u.c. Hroniska alkohola intoksikācija, St.Pēterburga, Juridiskais preses centrs, 2007 (kr.val.)
4.
1. Clarke ‘s Analysis of Drugs and Poisons,London: Pharmaceutical Press,Electronic version, 2004
5.
2. Toxicological analysis (Edited by R.Klaus Muller): Verlag Gesundheit Berlin, 1999
6.
3. Harald Schutz Benzodiazepines (A handbook. Basic Data, Analytical Methods)
7.
Pharmacokinetics and Comprehensive literature. Springer Verlag. New York, Berlin.
8.
Heidelberg Vol.I ,II, 1991,1996
Other Information Sources
1.
TEP 2013-2015 apstiprinātās alkohola, narkotiosko un psihotropo vielu piwerādīšanas metodes