Veidlapa Nr. M-3 (8)
Study Course Description
Medical Chemistry
Course Code
LFK_004
Branch of Science
Basic medicine
ECTS
3.00
Target Audience
Pharmacy
LQF
Level 7
Study Type And Form
Full-Time; Part-Time
Study Course Implementer
Course Supervisor
Reinis Vilšķērsts
Structure Unit Manager
Baiba Mauriņa
Structural Unit
Department of Applied Pharmacy
Contacts
Riga, 21 Consula Street, farmkk@rsu.lv, +371 67061544
About Study Course
Objective
To introduce students to medicinal chemistry and to enable students to the opportunity to learn about medicinal substance existing and change in the body from the administration until elimination.
Preliminary Knowledge
Knowledge of organic chemistry, physiology, biochemistry.
Learning Outcomes
Knowledge
1.Student will be able to: • Describe and explain process of mutual interactions of drug substances with various types of receptors; • Describe metabolic changes of drugs; • Explain drug interactions; • Explain prodrugs; • Identify and characterize frequently used groups of cardiovascular drugs.
Skills
1.Student will be able to: • Identify mechanisms of pharmacological action of the most important groups of medications (enzyme inhibitors, inducers, calcium channel blockers and other); • Objectively evaluate the possible origin of the substance interaction in case of co-administration; • Analyse the articles in medicinal chemistry.
Competences
1.Students will be able to assess the physico-chemical principles of drug substances, the possibility of interaction, origin of interaction and structure – activity interaction.
Assessment
Individual work
|
Title
|
% from total grade
|
Grade
|
|---|---|---|
|
1.
Individual work |
-
|
-
|
|
Individual and group situation tasks during seminars and colloquia; preparation of presentation, analysis of scientific publications in medicinal chemistry.
|
||
Examination
|
Title
|
% from total grade
|
Grade
|
|---|---|---|
|
1.
Examination |
-
|
-
|
|
Analysis of the article in medicinal chemistry, ability to create new hypothetical compounds with desirable pharmacological activity, presentation of results.
|
||
Study Course Theme Plan
FULL-TIME
Part 1
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Introduction, receptors and methods in medicinal chemistry
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Enzyme inhibitors. Introduction in Pharmacokinetics
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
3
|
Topics
|
G protein-coupled receptors
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Drug metabolism
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
3
|
Topics
|
Ion channels
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Cardiovascular drugs
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
3
|
Topics
|
Prodrugs
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
3
|
Topics
|
Biotransformation reactions of drug substances
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
3
|
Topics
|
Drug dose calculations by using the pharmacokinetic parameters
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
3
|
Topics
|
Multitarget drugs. Drug metabolism. Team work/seminar
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
3
|
Topics
|
Analysis of scientific publication of medicinal chemistry
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
3
|
Topics
|
Test
|
Total ECTS (Creditpoints):
3.00
Contact hours:
32 Academic Hours
Final Examination:
Exam (Written)
PART-TIME
Part 1
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
4
|
Topics
|
Introduction, receptors and methods in medicinal chemistry
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
4
|
Topics
|
Enzyme inhibitors. Introduction in Pharmacokinetics
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
4
|
Topics
|
Drug metabolism
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
4
|
Topics
|
Cardiovascular drugs
|
Total ECTS (Creditpoints):
3.00
Contact hours:
32 Academic Hours
Final Examination:
Exam (Written)
Bibliography
Required Reading
1.
Patrick, Graham L. An introduction to medicinal chemistry / Graham L. Patrick. 6th edition. NY: Oxford University Press, 2017. 1703 xxxi, 877 lpp.
2.
Strohfeldt-Venables, Katja Essentials of inorganic chemistry: for students of pharmacy, pharmaceutical sciences and medicinal chemistry / Katja A. Strohfeldt, School of Pharmacy, University of Reading, UK. Chichester, West Sussex: Wiley, 2015. xiv,
3.
Ahluwalia, V. K. Medicinal chemistry / V. K. Ahluwalia, Madhu Chopra. New Delhi : Ane Books India, 2008. xxii, 340 lpp. (akceptējams izdevums)
4.
The practice of medicinal chemistry / edited by Camille Georges Wermuth. 3rd edition. Amsterdam [etc.]: Elsevier/Academic Press, 2015. xxxix, 942 lpp.
Additional Reading
1.
Essentials of pharmaceutical chemistry / edited by Donald Cairns. 4th edition. London: Pharmaceutical Press, c2012. viii, 308 lpp.
2.
Medicinal Chemistry Self Assessment. By: Zavod, Robin M.; Harrold, Marc W. Bethesda, MD: ASHP. 2015.
3.
New Developments in Medicinal Chemistry. By: Gil, Irene C.; Ortega, Marta P. New York: Nova Science Publishers, Inc. 2009. eBook., ProQuest Ebook Central datubāzē
Other Information Sources
1.
Zinātniskās literatūras datubāzes: Pubmed; ScienceDirect (http://www.sciencedirect.com/) etc.