Veidlapa Nr. M-3 (8)
Study Course Description
Biochemistry in Dentistry
Course Code
CFUBK_074
Branch of Science
Clinical medicine; Medicinal Biochemistry
ECTS
3.00
Target Audience
Dentistry
LQF
Level 7
Study Type And Form
Full-Time
Study Course Implementer
Course Supervisor
Kalvis Brangulis
Structure Unit Manager
Pēteris Tretjakovs
Structural Unit
Department of Human Physiology and Biochemistry
Contacts
Riga, 16 Dzirciema Street, cfbk@rsu.lv, +371 67061550
About Study Course
Objective
To provide theoretical and practical knowledge of biochemical processes (digestion and metabolism) occurring in human organism on a molecular level. To facilitate the understanding of regulatory mechanisms of biochemical processes (with emphasis on carbohydrates) both on molecular and on physiological level. To elucidate the role of tissue specific proteins (extracellular matrix and connective tissue) differences in and specific adaptations of biochemical processes in various tissues/organs (cell metabolism). To elucidate biochemical processes related to the health of teeth and mouth.
Preliminary Knowledge
Course Medical Biochemistry: CFUBK_005.
Learning Outcomes
Knowledge
1.On completion of the study course students will be able to: • explain and describe digestion of proteins, lipids, nucleic acids, and carbohydrates and related pathologies; • name factors influencing enzyme’s activity; • characterise metabolic pathways in human metabolism that connect carbohydrates, lipids and amino acids and allow these groups to transform into each other, name hormones that regulate these transformations; • name and explain complications related to dysfunction of biochemical pathways studied in the course (e.g. lactoacidosis and ketoacidosis); • name and explain biochemical processes and specific adaptations of connective tissues; • name and explain biochemical processes that ensure the health of mouth and teeth.
Skills
1.1. Use of knowledge – ability to explain: • based on enzyme action mechanism, how enzymes activity is influenced by various factors; • the regulation of basic biochemical pathways and their role in the health of mouth and teeth; • the role of proteomics in dentistry. 2. Problem solving skills. 3. Skills to use scientific literature as a source of information. 4. Communication skills gained through organized team work.
Competences
1.On completion of the study course students will be able to: • assess possible disturbances in digestion and their relation to health of mouth and teeth; • assess possible disturbances in metabolic processes and their relation to health of mouth and teeth.
Assessment
Individual work
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Title
|
% from total grade
|
Grade
|
|---|---|---|
|
1.
Individual work |
-
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-
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Study course includes 48 hours of independent studies, 12 of those is going to be organized work for preparation of presentations. The rest of 36 hours include:
• independent studies of sources provided in e-studies (books, review articles);
• preparation of homework assigned in e-studies prepared for each seminar;
• scientific article analysis;
• preparation for an exam.
|
||
Examination
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Title
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% from total grade
|
Grade
|
|---|---|---|
|
1.
Examination |
-
|
-
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Examination (final assessment) includes general multiple choice questions in all topics covered during study course; multiple written tasks covering most important digestion and metabolism processes; written tasks which are designed to evaluate general understanding of relations between biochemical processes and health of mouth and teeth.
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||
Study Course Theme Plan
FULL-TIME
Part 1
-
Lecture
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Modality
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Location
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Contact hours
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|---|---|---|
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On site
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Auditorium
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2
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Topics
|
Macromolecules. Digestion of carbohydrates, related pathologies.
|
-
Lecture
|
Modality
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Location
|
Contact hours
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|---|---|---|
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On site
|
Auditorium
|
2
|
Topics
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Macromolecules. Digestion of peptides and lipids, related pathologies.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
4
|
Topics
|
Hydrolysis of nutrients, peptide chain cleavage, diseases related to digestion.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Bioenergetics, role of ATP in human metabolism, electron transport chain (ETC) and oxidative phosphorylation.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Glycolysis (aerobic and anaerobic) relation to other major metabolic processes.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
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|---|---|---|
|
On site
|
Auditorium
|
4
|
Topics
|
Oxidative stress, activators and inhibitors of ETC, anaerobic glycolysis, lactic acidosis – causes and treatments.
|
-
Lecture
|
Modality
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Location
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Contact hours
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|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
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Hormonal regulation of carbohydrate, lipid and amino acid metabolism.
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-
Class/Seminar
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Modality
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Location
|
Contact hours
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|---|---|---|
|
On site
|
Auditorium
|
4
|
Topics
|
Fuel metabolism in absorption and postabsorption period, and during exercise.
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-
Lecture
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Modality
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Location
|
Contact hours
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|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Tissue proteins – extracellular matrix and connective tissue.
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-
Lecture
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Modality
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Location
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Contact hours
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|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Biochemistry of teeth, saliva and dental caries, fluoride and fluorosis.
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-
Lecture
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Modality
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Location
|
Contact hours
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|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Proteomics of human saliva and teeth.
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-
Class/Seminar
|
Modality
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Location
|
Contact hours
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|---|---|---|
|
On site
|
Auditorium
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4
|
Topics
|
Presentations: novelty of the year in dental biochemistry.
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Total ECTS (Creditpoints):
3.00
Contact hours:
32 Academic Hours
Final Examination:
Exam (Written)
Bibliography
Required Reading
1.
DM Vasudevan, S Sreekumari, Kannan Vaidyanathan. 2017. Textbook of Biochemistry for Dental Students, 3rd Edition
2.
Lieberman, M.A. and Peet, A. 2018. Marks' Basic Medical Biochemistry. 4th ed. Lippincott Williams& Wilkins
3.
Nelson, D. L. and Cox, M. M. 2017. Lehninger Principles of Biochemistry. 6th ed. New York: W. H. Freeman & Co (or a newer version).
Additional Reading
1.
Baynes, J. W., Dominiczak, M. H. 2019. Medical Biochemistry. 4th ed.