Veidlapa Nr. M-3 (8)
Study Course Description
Medical Biochemistry
Course Code
CFUBK_085
Branch of Science
Clinical medicine; Medicinal Biochemistry
ECTS
7.00
Target Audience
Pharmacy
LQF
Level 7
Study Type And Form
Full-Time; Part-Time
Study Course Implementer
Course Supervisor
Ināra Nokalna
Structure Unit Manager
Pēteris Tretjakovs
Structural Unit
Department of Human Physiology and Biochemistry
Contacts
Riga, 16 Dzirciema Street, cfbk@rsu.lv, +371 67061550
About Study Course
Objective
1. To promote the acquisition of knowledge about the human body's chemical structure.
2. Learn the metabolism, the opportunities of regulation and changes in different situations.
3. Learn the possible routes of drugs, their inactivation processes.
Preliminary Knowledge
General and organic chemistry, biology in high school and FF II course program level.
Learning Outcomes
Knowledge
1.Upon successful completion of the course the student will be able to: 1. Substantiate according biochemical processes in the normal course and anticipate possible changes to various deviations. 2. Analyse and substantiate medication effects on metabolic process, as well as predict the consequences on the body. 3. Analyse biochemically collected data during drug therapy, to adequately process them and to make consequential and reasoned conclusions.
Skills
1.Upon completion of the study course the students will be able to: 1. Tell about the human body's molecules structure and importance. 2. Describe the enzyme activity. 3. Define the main principles of bioenergetics and metabolism, their regulation capabilities. 4. Analyse and evaluate carbohydrates, lipids and amino acid metabolic processes and its hormonal regulation. 5. Justify medication effects on metabolism in human body.
Competences
1.Will be able to predict and analyse the medication effects on metabolic processes, and to make consequential and reasoned conclusions by using data collected from drug therapy.
Assessment
Individual work
|
Title
|
% from total grade
|
Grade
|
|---|---|---|
|
1.
Individual work |
-
|
-
|
|
Study independently the latest scientific literature and integrate it in educational material.
In order to evaluate the quality of the study course as a whole, the student must fill out the study course evaluation questionnaire on the Student Portal.
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Examination
|
Title
|
% from total grade
|
Grade
|
|---|---|---|
|
1.
Examination |
-
|
-
|
|
1. Participation in practical classes.
2. Participation in the oral workshops.
3. Written colloquiums.
4. Written exam.
5. Final grade - cumulative, where 70% - exam grade and 30% - colloquium grade.
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Study Course Theme Plan
FULL-TIME
Part 1
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
COLLOQUIUM: Proteins. Enzymes
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Vitamins – water and fat soluble. Vitamins and coenzymes in medicine
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
Enzyme activity detection methods
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Carbohydrate metabolism
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
Nutrient digestive process
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Metabolism. Central catabolic pathways. Krebs cycle ATP formation pathways. Oxidants and antioxidative system
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
Enzyme activators and inhibitors
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Carbohydrate metabolism
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
Colloquium: Glucose metabolism
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
Proof of water-soluble vitamins
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
Most important functional groups in biochemistry and their properties
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
COLLOQUIUM: Bioenergetics
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Metabolism. Central catabolic pathways. Krebs cycle ATP formation pathways. Oxidants and antioxidative system
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Carbohydrate metabolism
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Metabolism. Central catabolic pathways. Krebs cycle ATP formation pathways. Oxidants and antioxidative system
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Simple proteins. Compound proteins. Chromoproteins. Enzymes
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
Proof of enzyme specificity.
Enzymatic reaction dependence on T ° and pH
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
Protein, fat and carbohydrate digestion
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
COLLOQUIUM: Vitamins
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
Seminar: Bioenergy. Antioxidant system. SDH demonstration. Hydroperoxidases
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Simple proteins. Compound proteins. Chromoproteins. Enzymes
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
Proof reactions of amino acids. Proof reactions of amino acids. Protein quantitative determination techniques. Protein quantitative determination techniques. Chromoproteins. Hemoglobin forms of spectroscopy
|
Total ECTS (Creditpoints):
4.00
Contact hours:
46 Academic Hours
Final Examination:
Test (Semester)
Part 2
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
Seminar: Triacylglycerol metabolism. Fatty acid metabolism. Ketones. Laboratory work: Demonstration of ketones
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Lipid metabolism
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Lipid metabolism
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
Seminar: Glycolytic pathway of glucose metabolism. Oxidative decarboxylation of PVA. Gluconeogenesis. Seminar: Glycogen synthesis and degradation process. Non-energy pathways of glucose metabolism Lab work: Lactate proof in muscles
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Introduction to biochemistry. Biochemistry and pharmaceuticals. Proteins
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Amino acid metabolism
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Hormonal regulation principles of metabolism. Metabolism of xenobiotics
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
Blood and urine chemical composition. Creatinine and urea determination
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Amino acid metabolism
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
Seminar: Amino acids fund and their uasge. AA catabolism. Specific properties of amino acids
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
COLLOQUIUM: Lipid metabolism. Amino acid metabolism
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
Seminar: Cholesterol. Synthesis of phospholipids and fats. Lab. work: Determination of cholesterol in the analysis
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Amino acid metabolism
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Enzymes
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Enzymes
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
Seminar: Glycolytic pathway of glucose metabolism. Oxidative decarboxylation of PVA. Gluconeogenesis. Seminar: Glycogen synthesis and degradation process. Non-energy pathways of glucose metabolism Lab work: Lactate proof in muscles
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
Hormonal regulation of metabolism. Xenobiotics metabolism
|
Total ECTS (Creditpoints):
3.00
Contact hours:
32 Academic Hours
Final Examination:
Exam (Written)
PART-TIME
Part 1
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
Seminar: Triacylglycerol metabolism. Fatty acid metabolism. Ketones. Laboratory work: Demonstration of ketones
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Hormonal regulation principles of metabolism. Metabolism of xenobiotics
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
COLLOQUIUM: Lipid metabolism. Amino acid metabolism
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Enzymes
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Amino acid metabolism
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
Seminar: Glycolytic pathway of glucose metabolism. Oxidative decarboxylation of PVA. Gluconeogenesis. Seminar: Glycogen synthesis and degradation process. Non-energy pathways of glucose metabolism Lab work: Lactate proof in muscles
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
Seminar: Amino acids fund and their uasge. AA catabolism. Specific properties of amino acids
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Carbohydrate metabolism
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
Proof of enzyme specificity.
Enzymatic reaction dependence on T ° and pH
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
2
|
Topics
|
COLLOQUIUM: Proteins. Enzymes
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Vitamins – water and fat soluble. Vitamins and coenzymes in medicine
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Introduction to biochemistry. Biochemistry and pharmaceuticals. Proteins
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Lipid metabolism
|
Total ECTS (Creditpoints):
7.00
Contact hours:
26 Academic Hours
Final Examination:
Exam
Bibliography
Required Reading
1.
V. W. Rodwell, D. K. Granner, D.A. Bender, P. J. Kennelly. Harper's Illustrated Biochemistry (30th edition by Mc Graw Hill education), 2018: 820.
Additional Reading
1.
R. A. Harvey, D. R. Ferrier. Lippincott's Illustrated Reviews: Biochemistry (Lippincott's Illustrated Reviews Series), 2021: 544.
2.
Pub Med un citas datu bāzes.
3.
L. W. Janson and M. E. Tischler „The Big Picture. Medical Biochemistry” Mc Graw Hill Medical, 2012
Other Information Sources
1.
e-studijas