Veidlapa Nr. M-3 (8)
Study Course Description
Genetic and Molecular Biological Diagnosis
Course Code
RHE_052
Branch of Science
Clinical medicine
ECTS
9.00
Target Audience
Medicine
LQF
Level 8
Study Course Implementer
Course Supervisor
Sandra Lejniece
Residency Speciality
Speciality
Hematologist
Supervisor of Medical Speciality
Sandra Lejniece
Contacts
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About Study Course
Objective
To ensure acquisition and improvement of theoretical knowledge and practical skills in genetic and molecular biological diagnosis in accordance with the requirements of the haematology specialty in order to prepare the doctor for certification in the haematology specialty.
Learning Outcomes
Knowledge
1.- Knows about molecular biological and genetic methods in leukaemia diagnosis, molecular remission and evaluation of treatment results.; - Knows about cytogenetic analysis, in situ hybridisation, polymerase chain reaction, application of these methods in haematology; - Knows about genetic diagnosis of haemophilia and thrombophilia.
Skills
1.- Able to analyse the results of molecular biological and genetic tests; - Able to cytogenetic analyses in haematology; - Able to analyse genetic testing results for haemophilia and thrombophilia.
Competences
1.Application of molecular biological and genetic tests for haemophilia and thrombophilia.
Assessment
Individual work
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Title
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% from total grade
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Grade
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1.
Individual work |
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1. Independently studies the literature related to the course topics;
2. Independently prepares for seminars;
3. Gets acquainted with and analyses medical documentation;
4. Completes medical documentation;
5. Independently follows the instructions of the certified specialist.
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Examination
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Title
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% from total grade
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Grade
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|---|---|---|
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1.
Examination |
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-
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Mandatory attendance of seminars (100%) and performance of practical work (100%) in each study course.
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Study Course Theme Plan
FULL-TIME
Part 1
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Seminar
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Modality
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Location
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-
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Topics
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Molecular biological and genetic methods in leukaemia diagnosis, molecular remission and evaluation of treatment results.
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Seminar
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Modality
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Location
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-
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Topics
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Cytogenetic analysis, in situ hybridisation, polymerase chain reaction. Application of these methods in haematology.
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Seminar
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Modality
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Location
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Topics
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Genetic diagnosis of haemophilia and thrombophilia
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Total ECTS (Creditpoints):
9.00
Number of Residency Seminars:
3
Length (weeks):
7
Final Examination:
Residency exam (Theory and practice)
Bibliography
Required Reading
1.
P.Turnpenny, S.Ellard. Emery’s elements of medical genetics and genomics . 16th edition. ELSEVIER,2021. (ISBN-13: 978-0702079665; ISBN-10: 0702079669)
2.
R.J.McKinlay Gardner, G.R.Sutherland, L.G.Shaffer. Chromosome abnormalities and genetic counseling. 5th edition. OXFORD. 2018. (ISBN-13 9780199329007, 10.1093/med/9780199329007.001.0001)
3.
Jean McGowan-Jordan,Ros J.Hastings,Sarah Moore An International System for Human Cytogenetic Nomenclature Karger 2020. Reprint of Cytogenetic and Genome Research(ISSN 1424-8581) Vol.160,No.7-8, 2020
4.
Lynn B. Jorde, PhD, John C. Carey, MD, MPH and Michael J. Bamshad, MD. Medical Genetics. 5th edition. Elsevier 2016. (ISBN: 9780323188357)
5.
Sverre Heim, Felix Mitelman. Cancer Cytogenetics. 4th Edition. WILEY Blackwell,2015. (ISBN 978-1-118-79553-8)
6.
Mahler Zneimer S. Cytogenetic Abnormalities. WILEY Blackwell,2014. (ISBN 978-1-118-91249-2)
7.
Swerdlow SH, Campo E., Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J (Eds). WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Revised 4th Edition. IARC: Lyon 2017. (ISBN 978-92-832-4494-3)
8.
Gulbis E, Bandere B, Gavars D un citi. Klīnisko analīžu rokasgrāmata. E.Gulbja Laboratorija. 2018. (ISBN 978-9934-19-724-6)
9.
Arber DA, Orazi A, Hasserjian R, et al. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood 2016; 127:2391-2405. https://doi.org/10.1182/blood-2016-03-643544
10.
Emile JF, Abla O, Fraitag S, et al. Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages. Blood 2016; 127:2672.
11.
S.Lejniece. Klīniskā hematoloģija. Medicīnas Apgāds, 2020.
12.
Klīnisko analīžu rokasgrāmata. E.Gulbja laboratorija. Izdevējs E.Gulbja laboratorija, 2019.
13.
Alla Rivkina. Plūsmas citometrijas metode hematoloģisko slimību diagnostikā. SIA Medicīnas apgāds, 2019