Paediatric Hemato-Oncology
Study Course Implementer
Rīga, Vienības gatve 45, pk@rsu.lv, +371 67621730
About Study Course
Objective
To provide students with in‑depth knowledge of paediatric oncology. In the study process, special emphasis will be placed on the principles of chemotherapy, its mechanisms of action and the most common complications, especially febrile neutropenia as one of the most frequent and potentially life‑threatening complications after chemotherapy, as well as its timely recognition, emergency management and treatment algorithms. The program will also include knowledge of modern therapeutic options in paediatric haemato-oncology, including targeted therapy, immunotherapy, monoclonal antibodies, cell therapy (for example, CAR‑T therapy) and the principles of personalized treatment, highlighting their importance in improving treatment effectiveness and reducing toxicity.Particular attention will also be paid to central nervous system (CNS) tumours as the most common solid tumours in childhood, their clinical signs, neurological symptoms, diagnostic methods and multimodal treatment (surgery, radiotherapy, chemotherapy). Students will also acquire knowledge about late treatment effects, including cardiotoxicity, endocrine disorders, growth and developmental delay, neurocognitive impairments and the risk of secondary tumours, emphasizing the importance of long‑term follow‑up and multidisciplinary care. The aim of the course is to develop clinical reasoning and the ability to critically evaluate strategies for diagnostics, treatment, complication prevention and long‑term follow‑up in paediatric haemato-oncology, ensuring competent and safe care for paediatric patients.
Preliminary Knowledge
Basic knowledge of human anatomy, physiology, pathology, immunology, and an introduction to pediatrics.
Learning Outcomes
Knowledge
1.The student understands the basic principles of paediatric oncology. The student is familiar with the mechanisms of action of chemotherapy, the principles of developing treatment protocols, risk stratification, and modern therapeutic options (targeted therapy, immunotherapy, cell therapy); understands the most common acute complications, especially febrile neutropenia as an emergency condition, as well as the late effects of oncological treatment and the need for long term follow up.
Skills
1.The student is able to analyse clinical cases of paediatric haemato-oncology patients, recognize early signs of malignant diseases, and plan diagnostic investigations. The student is able to recognize febrile neutropenia, assess its severity, and justify the tactics of emergency therapy. The student can interpret laboratory and instrumental examinations and assess signs of therapy-induced toxicity. The student is able to identify possible late effects and plan long-term follow-up.
Competences
1.The student is able to independently apply acquired knowledge in paediatric haemato-oncology to the assessment of clinical situations, collaborating with a multidisciplinary team and providing safe, evidence-based care. The student is aware of the importance of timely recognition of acute complications, as well as the role of long-term sequelae prevention and the education of patients and their families, ensuring continuous care from diagnosis to long-term follow-up.
Assessment
Individual work
|
Title
|
% from total grade
|
Grade
|
|---|---|---|
|
1.
Presentation/ clinical case |
50.00% from total grade
|
10 points
|
|
Clinical case analysis of CNS tumours in children |
||
Examination
|
Title
|
% from total grade
|
Grade
|
|---|---|---|
|
1.
Test |
50.00% from total grade
|
10 points
|
|
Assessment of theoretical knowledge on the topics of the study course |
||
Study Course Theme Plan
-
Video Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
Off site
|
Video
|
2
|
Topics
|
Febrile neutropenia in pediatric hemato-oncology
|
-
Video Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
Off site
|
Video
|
2
|
Topics
|
Basic principles of chemotherapy in pediatric oncology
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
3
|
Topics
|
Chemotherapy in paediatric oncology: mechanisms of action, protocols, and toxicity
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
3
|
Topics
|
Febrile neutropenia: the most common and most dangerous chemotherapy complication – diagnosis, emergency management, and prevention
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
3
|
Topics
|
Central nervous system tumours in children: clinical features, diagnostics, and multimodal therapy (I)
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
3
|
Topics
|
Central nervous system tumours in children: clinical features, diagnostics, and multimodal therapy (II)
|
-
Video Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
Off site
|
Video
|
2
|
Topics
|
Late effects of oncological treatment in children
|
-
Video Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
Off site
|
Video
|
2
|
Topics
|
Central nervous system tumors in children
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
3
|
Topics
|
Modern therapeutic options in paediatric oncology(I)
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
3
|
Topics
|
Modern therapeutic options in paediatric oncology (II)
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
3
|
Topics
|
Treatment side effects and late post therapy consequences: long term follow up and multidisciplinary care (I)
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
3
|
Topics
|
Treatment side effects and late post therapy consequences: long term follow up and multidisciplinary care (II)
|
Bibliography
Required Reading
Blaney SM, Helman LJ, Adamson PC (eds). Pizzo & Poplack’s Principles and Practice of Pediatric Oncology. 9th ed. Lippincott Williams & Wilkins; 2025.Suitable for English stream
Additional Reading
Fish J, Lipton J, Lanzkowsky P (eds). Lanzkowsky’s Manual of Pediatric Hematology and Oncology. 7th ed. Elsevier; 2021.Suitable for English stream
Schmidt CW, Menezes FG. Drug Therapy and Interactions in Pediatric Oncology: A Pocket Guide. Springer; 2016.
Schmidt CW. Pediatric Oncologic Pharmacy: A Complete Guide to Practice. 2nd ed. Springer Cham; 2025.Suitable for English stream
Orkin SH, Nathan DG, Ginsburg D, Look AT, Fisher DE, Lux SE (eds). Nathan and Oski’s Hematology of Infancy and Childhood. 7th ed. Elsevier; 2008.Suitable for English stream