Veidlapa Nr. M-3 (8)
Study Course Description

Paediatric Hemato-Oncology

Main Study Course Information

Course Code
PEK_068
Branch of Science
Clinical medicine; Paediatrics
ECTS
3.00
Target Audience
Medicine
LQF
Level 7
Study Type And Form
Full-Time

Study Course Implementer

Course Supervisor
Structure Unit Manager
Structural Unit
Department of Paediatrics
Contacts

Rīga, Vienības gatve 45, pk@rsu.lv, +371 67621730

About Study Course

Objective

To provide students with in‑depth knowledge of paediatric oncology. In the study process, special emphasis will be placed on the principles of chemotherapy, its mechanisms of action and the most common complications, especially febrile neutropenia as one of the most frequent and potentially life‑threatening complications after chemotherapy, as well as its timely recognition, emergency management and treatment algorithms. The program will also include knowledge of modern therapeutic options in paediatric haemato-oncology, including targeted therapy, immunotherapy, monoclonal antibodies, cell therapy (for example, CAR‑T therapy) and the principles of personalized treatment, highlighting their importance in improving treatment effectiveness and reducing toxicity.Particular attention will also be paid to central nervous system (CNS) tumours as the most common solid tumours in childhood, their clinical signs, neurological symptoms, diagnostic methods and multimodal treatment (surgery, radiotherapy, chemotherapy). Students will also acquire knowledge about late treatment effects, including cardiotoxicity, endocrine disorders, growth and developmental delay, neurocognitive impairments and the risk of secondary tumours, emphasizing the importance of long‑term follow‑up and multidisciplinary care. The aim of the course is to develop clinical reasoning and the ability to critically evaluate strategies for diagnostics, treatment, complication prevention and long‑term follow‑up in paediatric haemato-oncology, ensuring competent and safe care for paediatric patients.

Preliminary Knowledge

Basic knowledge of human anatomy, physiology, pathology, immunology, and an introduction to pediatrics.

Learning Outcomes

Knowledge

1.The student understands the basic principles of paediatric oncology. The student is familiar with the mechanisms of action of chemotherapy, the principles of developing treatment protocols, risk stratification, and modern therapeutic options (targeted therapy, immunotherapy, cell therapy); understands the most common acute complications, especially febrile neutropenia as an emergency condition, as well as the late effects of oncological treatment and the need for long term follow up.

Skills

1.The student is able to analyse clinical cases of paediatric haemato-oncology patients, recognize early signs of malignant diseases, and plan diagnostic investigations. The student is able to recognize febrile neutropenia, assess its severity, and justify the tactics of emergency therapy. The student can interpret laboratory and instrumental examinations and assess signs of therapy-induced toxicity. The student is able to identify possible late effects and plan long-term follow-up.

Competences

1.The student is able to independently apply acquired knowledge in paediatric haemato-oncology to the assessment of clinical situations, collaborating with a multidisciplinary team and providing safe, evidence-based care. The student is aware of the importance of timely recognition of acute complications, as well as the role of long-term sequelae prevention and the education of patients and their families, ensuring continuous care from diagnosis to long-term follow-up.

Assessment

Individual work

Title
% from total grade
Grade
1.

Presentation/ clinical case

50.00% from total grade
10 points

Clinical case analysis of CNS tumours in children

Examination

Title
% from total grade
Grade
1.

Test

50.00% from total grade
10 points

Assessment of theoretical knowledge on the topics of the study course

Study Course Theme Plan

FULL-TIME
Part 1
  1. Video Lecture

Modality
Location
Contact hours
Off site
Video
2

Topics

Febrile neutropenia in pediatric hemato-oncology
  1. Video Lecture

Modality
Location
Contact hours
Off site
Video
2

Topics

Basic principles of chemotherapy in pediatric oncology
  1. Class/Seminar

Modality
Location
Contact hours
On site
Study room
3

Topics

Chemotherapy in paediatric oncology: mechanisms of action, protocols, and toxicity
  1. Class/Seminar

Modality
Location
Contact hours
On site
Study room
3

Topics

Febrile neutropenia: the most common and most dangerous chemotherapy complication – diagnosis, emergency management, and prevention
  1. Class/Seminar

Modality
Location
Contact hours
On site
Study room
3

Topics

Central nervous system tumours in children: clinical features, diagnostics, and multimodal therapy (I)
  1. Class/Seminar

Modality
Location
Contact hours
On site
Study room
3

Topics

Central nervous system tumours in children: clinical features, diagnostics, and multimodal therapy (II)
Total ECTS (Creditpoints):
1.50
Contact hours:
16 Academic Hours
Final Examination:
Test (Semester)
Part 2
  1. Video Lecture

Modality
Location
Contact hours
Off site
Video
2

Topics

Late effects of oncological treatment in children
  1. Video Lecture

Modality
Location
Contact hours
Off site
Video
2

Topics

Central nervous system tumors in children
  1. Class/Seminar

Modality
Location
Contact hours
On site
Study room
3

Topics

Modern therapeutic options in paediatric oncology(I)
  1. Class/Seminar

Modality
Location
Contact hours
On site
Study room
3

Topics

Modern therapeutic options in paediatric oncology (II)
  1. Class/Seminar

Modality
Location
Contact hours
On site
Study room
3

Topics

Treatment side effects and late post therapy consequences: long term follow up and multidisciplinary care (I)
  1. Class/Seminar

Modality
Location
Contact hours
On site
Study room
3

Topics

Treatment side effects and late post therapy consequences: long term follow up and multidisciplinary care (II)
Total ECTS (Creditpoints):
1.50
Contact hours:
16 Academic Hours
Final Examination:
Exam

Bibliography

Required Reading

1.

Blaney SM, Helman LJ, Adamson PC (eds). Pizzo & Poplack’s Principles and Practice of Pediatric Oncology. 9th ed. Lippincott Williams & Wilkins; 2025.Suitable for English stream

Additional Reading

1.

Fish J, Lipton J, Lanzkowsky P (eds). Lanzkowsky’s Manual of Pediatric Hematology and Oncology. 7th ed. Elsevier; 2021.Suitable for English stream

2.

Schmidt CW, Menezes FG. Drug Therapy and Interactions in Pediatric Oncology: A Pocket Guide. Springer; 2016.

3.

Schmidt CW. Pediatric Oncologic Pharmacy: A Complete Guide to Practice. 2nd ed. Springer Cham; 2025.Suitable for English stream

4.

Orkin SH, Nathan DG, Ginsburg D, Look AT, Fisher DE, Lux SE (eds). Nathan and Oski’s Hematology of Infancy and Childhood. 7th ed. Elsevier; 2008.Suitable for English stream