Veidlapa Nr. M-3 (8)
Study Course Description
Pharmaceutical Chemistry
Course Code
LFK_009
Branch of Science
Basic medicine
ECTS
13.00
Target Audience
Pharmacy
LQF
Level 7
Study Type And Form
Full-Time
Study Course Implementer
Course Supervisor
Dace Bandere
Structure Unit Manager
Baiba Mauriņa
Structural Unit
Department of Applied Pharmacy
Contacts
Riga, 21 Consula Street, farmkk@rsu.lv, +371 67061544
About Study Course
Objective
Course is aimed to acquire the theoretical knowledge and practical skills that can be used in drug quality control. • Promote knowledge of the main classes of medicinal products and their chemical properties; • Promote understanding of drug structure, synthesis, quality control and specifics of use; • Master the tactics of naming medicines and methods of testing the goodness of medicines; • Carry out the analysis of drug substances containing different dosage forms on the basis of physical and chemical properties, chemical structure and stability.
Preliminary Knowledge
Basic knowledge in inorganic, organic and analytical chemistry, physical pharmacy.
Learning Outcomes
Knowledge
1.On successful course completion: • Students should know structures and names of drug substances, methods of drug quality analysis, • be able to identify a compound by reactions of key functional groups, • be able to test the quality of different drug substances, • be able to identify the structural elements of vitamins, hormones and antibiotic drug substances and name a specific drug-containing preparation; • be able to explain the physico-chemical properties of vitamins, hormones and antibiotic drug substances, • be able to compare and select methods for drug substance synthesis, qualitative and quantitative analysis depending on the particular drug substance preparation.
Skills
1.On successful course completion students will be able to: • choose and apply chemical and instrumental methods of analysis of drugs, • systematize scientific information of the different groups of medications, their characteristics, properties and use in medicine.
Competences
1.On successful course completion students will be able to evaluate and present the information of drug quality control; Students will be able to independently test the quality of the drug substance based on its physical and chemical properties.
Assessment
Individual work
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Title
|
% from total grade
|
Grade
|
|---|---|---|
|
1.
Individual work |
-
|
-
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|
During the course students are asked to work with pharmaceutical literature sources to find drug quality control methods. Students are also independently preparing for each lab work finding answers for a set of specific questions in connection with the experimental tasks that helps to understand the experimental work during the labs. A research work – literature review. Study course evaluation questionnaire.
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Examination
|
Title
|
% from total grade
|
Grade
|
|---|---|---|
|
1.
Examination |
-
|
-
|
|
Active participation in practical classes and accuracy of laboratory work analyses; objective tests, report - literature review, presentations.
Assessment – Colloquium grades 80%, report – 20%. Summative exam. Exam 50% of the grade.
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Study Course Theme Plan
FULL-TIME
Part 1
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
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On site
|
Auditorium
|
2
|
Topics
|
Methods of European Pharmacopeia. Quality control of water and injection water. Purified and injection water acquisition and quality testing.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
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|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Inorganic drugs. Chemical structure, methods of analysis, the use of medicine.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Analysis of functional groups and nomenclature of drugs
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Analysis of functional groups and nomenclature of drugs
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Anaesthesic drugs. Chemical structure, methods of analysis, medical use.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Non-steroidal anti inflamatory drugs and analgetics. Chemical structure, methods of analysis, medical use.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Synthetic antimicrobial drugs. Chemical structure, methods of analysis, medical use.TB drugs. Antiviral and Antiparasitic drugs. Chemical structure, methods of analysis, medical use.
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-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Water and fat-soluble vitamins: chemical structure, physico-chemical properties, methods of analysis, the use of medicine.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Water and fat-soluble vitamins: chemical structure, physico-chemical properties, methods of analysis, the use of medicine.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Antibiotics and steroidal hormones: chemical structure, physico-chemical properties, methods of analysis, the use of medicine.
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-
Class/Seminar
|
Modality
|
Location
|
Contact hours
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|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Preparation of standard solutions. Determination of drug turbidity, color and impurities.
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-
Class/Seminar
|
Modality
|
Location
|
Contact hours
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|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Analysis of inorganic substances.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
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|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Quality control of NaF and CaCl2.
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-
Class/Seminar
|
Modality
|
Location
|
Contact hours
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|---|---|---|
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On site
|
Laboratory
|
4
|
Topics
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Quality control of Sodium thiosulfate sol.
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-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Analysis of functional groups.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Quality control of Rezorcin.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
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|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Quality control of Na citrate sol.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Quality control of Anesthesia drugs and NSAIDs
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Quality control of Procaine sol. and Paracetamol.
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-
Class/Seminar
|
Modality
|
Location
|
Contact hours
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|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
NSAIDs melting point detection.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
NSAIDs melting point detection.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Colloquium – Anesthesia drugs and NSAIDs.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Colloquium – Anesthesia drugs and NSAIDs.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Pharmaceutical calculations
|
Total ECTS (Creditpoints):
7.00
Contact hours:
76 Academic Hours
Final Examination:
Test (Semester)
Part 2
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Quality control of Sulfonamides and Isoniazid.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Spectroscopic and jodometric analysis of Nitrofuran sol.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Colloquium – CNS drugs. Drugs Used in Respiratory and Gastrointestinal Disorders. Antibacterial drugs.
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-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Control analysis – identification of an unknown medicinal substance.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Control analysis – identification of an unknown medicinal substance.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Presentation, analysis, discussion of the individual project.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Introduction of express analysis. Express analysis of mixture, quantitative calculations (seminar).
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Vitamins identification reactions. Unknown vitamin preparation determination.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Colloquium: Vitamins: synthesis, analysis and the use of medicine. Situation tasks of express analysis.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Analysis of oral solutions.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Quantitative analysis of multi dose powders.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Antibiotics: chemical structure, physico-chemical properties, methods of analysis, the use of medicine.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Hormones: chemical structure, physico-chemical properties, methods of analysis, the use of medicine.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Final test - Pharmaceutical calculations.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
HPLC in drug analysis
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Gas chromatography for the analysis of ethanol solutions.
|
Total ECTS (Creditpoints):
6.00
Contact hours:
64 Academic Hours
Final Examination:
Exam (Written)
Bibliography
Required Reading
1.
European Pharmacopoeia. 10th edition. Strasbourg: Council of Europe, 2019-2021. RSU: Informācijas centrs
2.
RSU abonētās zinātniskās datubāzes.
3.
Ārvalstu studentiem/For international students
4.
European Pharmacopoeia. 10th edition. Strasbourg: Council of Europe, 2019-2021. RSU: Informācijas centrs
Additional Reading
1.
Patrick, Graham L. An introduction to medicinal chemistry. 2017.
2.
Hansen, S., Pedersen-Bjergaard, S., Rasmussen, K. Introduction to Pharmaceutical Chemical Analysis. Wiley-Blackwell, 2011.
3.
Hill R.G. (ed) Drug Discovery and Development, Hill R.G, 2022.
4.
Беликов, В. Г. Фармацевтическая химия. В 2 ч. Ч. 1: Общая фармацевтическая химия. Ч. 2: Специальная фармацевтическая химия: Учебник для мед. вузов. М.: Медпресс-информ, 1985. 624 с.
5.
Shargel, L, Wu-Pong, S and Yu, A. Shargel and Yu's applied biopharmaceutics and pharmacokinetics: Bioavailability and bioequivalence. 8th ed. McGraw Hill: New York, USA, 2022.
6.
Block, I .H., Beale, I. M. Wilson and Gisvold Textbook of Organic Medicinal and Pharmaceutical Chemistry. Delgado JN, Remers WA, (Eds.)., 12th ed. 2011.
7.
Applications of Pharmacokinetic Principles in Drug Development. Editor Krishna R. Kluwer. Academic / Plenum Publishers, 2004. pp. 556.
8.
Hillisch, A., Hilgenfeld, R. (eds). Modern Methods of Drug Discovery. Basel – Boston – Berlin, 2003.
9.
Wermuth, C.G. (ed). The Practice of Medicinal Chemistry, Amsterdam, 2015.
10.
Cairns, D. Essentials of Pharmaceutical Chemistry. Pharmaceutical Press, London 2012.
11.
Ābola, D., Štokmane, A., Vīgestāne, R. Zāļu analīze aptiekā. Rīga: Zvaigzne, 1991.
12.
Ārvalstu studentiem/For international students
13.
Patrick, Graham L. An introduction to medicinal chemistry. 2017.
14.
Hansen, S., Pedersen-Bjergaard, S., Rasmussen, K. Introduction to Pharmaceutical Chemical Analysis. Wiley-Blackwell, 2011.
15.
Hill R.G. (ed) Drug Discovery and Development, Hill R.G, 2022.
16.
Shargel, L, Wu-Pong, S and Yu, A. Shargel and Yu's applied biopharmaceutics and pharmacokinetics: Bioavailability and bioequivalence. 8th ed. McGraw Hill: New York, USA, 2022.