Veidlapa Nr. M-3 (8)

Study Course Description

Hospital Paediatrics with Consultative Outpatient Work, Including Outpatient Paediatrics/Genetics

Main Study Course Information

Course Code

RBH_036

Branch of Science

Clinical medicine

ECTS

5.00

Target Audience

Medicine

LQF

Level 8

Study Course Implementer

Course Supervisor

Žanna Kovaļova

Residency Speciality

Speciality

Pediatric oncohematologist

Supervisor of Medical Speciality

Žanna Kovaļova

Contacts

About Study Course

Objective

To provide theoretical knowledge acquisition in the area of genetics of childhood leukemias, in the area of molecular diagnostic methods, in the area of congenital syndromes related to tumours.

Learning Outcomes

Knowledge

1.Use of knowledge about molecular diagnostic methods, understand the concept of minimal residual disease in paediatric onco-haematology. Recognise congenital syndromes related to tumours.

Skills

1.Apply in practice minimal residual disease (MRD) in diagnostics in childhood leukemias, analyse MRD results and influence to choice of therapy.

Competences

1.Use of genetic testing results to correct and prompt diagnostics, application of these tests, analyse feasibility of genetic methods, influence of choice for target therapy.

Assessment

Individual work

Title	% from total grade	Grade
1. Individual work	-	-
Preparation of a presentation.

Examination

Title	% from total grade	Grade
1. Examination	-	-
After each module (rotation cycle) medical resident’s theoretical and practical knowledge is assessed in a 10-point grade system by the medical resident's supervisor of the rotation cycle by making a respective record in the medical resident’s book.

Study Course Theme Plan

FULL-TIME

Part 1

Seminar

Modality	Location
On site	Auditorium

Topics

Congenital factors, toxic gene factors. Genetic changes associated with tumours and their proving methods. Genetic diagnostic methods in case of tumours.

Seminar

Modality	Location
On site	Auditorium

Topics

Molecular diagnostic methods, their use in case of haematological neoplasias.

Seminar

Modality	Location
On site	Auditorium

Topics

Minimal residual disease in paediatric onco-haematology. Congenital syndromes related to tumours.

Total ECTS (Creditpoints):

5.00

Number of Residency Seminars:

Length (weeks):

Final Examination:

Residency exam (Theory and practice)

Bibliography

Required Reading

Hodgson SV, Maher ER. A practical guide to human cancer genetics. 3rd edition, 2014. (akceptējams izdevums)

Jones (ed). Smith's Recognizable Patterns of Human Malformation. 2022.

Hennekam, Krantz, Allanson (eds). Gorlin's Syndromes of the Head and Neck. 2010. (akceptējams izdevums)

Nussbaum, McInnes, Willard (eds). Thompson and Thompson Genetics in Medicine. 2024.

Other Information Sources

Dr. Klinepeter's article on "Developmental 'Red Flags'" from Triad Smarty Pants.

Tokyo Medical University Genetics Study Group.

American Journal of Medical Genetics. Vol 149A, January 2009.

Online Mendelian Inheritance in Man (OMIM).

GeneReviews.

Karyotyping exercises.