Veidlapa Nr. M-3 (8)
Study Course Description
Medical Biochemistry
Course Code
CFUBK_091
Branch of Science
Basic medicine; Clinical Pharmacy
ECTS
14.00
Target Audience
Medicine
LQF
Level 7
Study Type And Form
Full-Time
Study Course Implementer
Course Supervisor
Dace Reihmane
Structure Unit Manager
Pēteris Tretjakovs
Structural Unit
Department of Human Physiology and Biochemistry
Contacts
Riga, 16 Dzirciema Street, cfbk@rsu.lv, dace.reihmane@rsu.lv, +371 67061550
About Study Course
Objective
To provide theoretical and practical knowledge of biochemical processes (digestion and metabolism) occurring in human organism on a molecular level. To facilitate the understanding of regulatory mechanisms of biochemical processes both on molecular as well as on physiological level. To elucidate differences in and specific adaptations of biochemical processes in various tissues/organs (cell metabolism). To gain insight in pathological processes related to energy metabolism. To know the use of important biochemical markers and understand basic principles of their quantitative and qualitative detection methods.
Preliminary Knowledge
Physics, chemistry, biology, anatomy.
Learning Outcomes
Knowledge
1.On completion of the course students will be able to: • explain and describe the synthesis and hydrolysis of proteins, lipids, nucleic acids, and carbohydrates; • name factors influencing enzyme activity; • classify digestive enzymes according to their mechanism of action and name the enzymes involved in digestion of the main nutrient classes; • recognise and name the basic metabolites of carbohydrate metabolism, name enzymes and characterise their principle of action, explain the role and regulation of various metabolic pathways and cycles (e.g. glycolysis, oxidative decarboxylation and the Krebs cycle, glycogen synthesis and breakdown); • identify and recognise the major metabolites of lipid metabolism, name enzymes and describe their principle of action, explain the role and regulation of various metabolic pathways (e.g. beta oxidation, fatty acid and cholesterol synthesis); • recognise and name the major metabolites of amino acid metabolism, name enzymes and characterise the principle of action, explain the role and regulation of metabolic pathways (e.g. ammonium detoxification and urea cycle); • describe metabolic pathways in human metabolism that connect carbohydrates, lipids and amino acids and allow these groups of substances to transform into each other, name hormones that affect these transformations; • name and explain complications related to dysfunction of biochemical pathways studied in the course (e.g. lactoacidosis and ketoacidosis); • name and explain differences between biochemical processes of various tissues/organs (cellular metabolism) and their specific adaptations; • learn methods required for basic biochemistry analysis performed in medicine.
Skills
1.1. Use of knowledge – ability to: • explain how enzymes activity is affected, based on the mechanism of action of enzymes; • explain how molecules are sequentially digested during digestion process, identify end products of digestion process; • explain step by step using the appropriate metabolic pathways, carbohydrates degradation for energy generation and carbohydrate storage; • explain sequentially with appropriate metabolic pathways, lipid breakdown for energy extraction and carbohydrates storage; • explain sequentially using the appropriate metabolic pathways, the degradation of amino acids for energy generation, fate of the carbon skeleton and the ammonia detoxification; • explain step by step using the appropriate metabolic pathways, interactions between fats and sugars and evaluate in which metabolic situations these transformations take place; • explain the application and basic principle of biochemical tests of biological samples (blood and urine) used to determine the functional state of the human body. 2. Problem solving skills. 3. Skills to use scientific literature as a source of information. 4. Laboratory safety skills. 5. Communication skills gained through organized team work.
Competences
1.On completion of the course students will be able to: • assess possible changes in the regulation of enzymes in various homeostatic disorders and predict the consequences on total metabolism; • analyse possible changes on the digestive process with low activity of certain digestive enzymes, and predict consequences on the total spectrum of absorbed nutrients; • analyse possible changes in human metabolism in the presence of some carbohydrate, lipid or amino acid pathway disorders and predict their effects on other metabolic pathways and human homeostasis; • use the skills acquired in laboratory work – prepare and conduct laboratory experiment, use the relevant equipment and evaluate the results in further practical or scientific work; • integrate knowledge of biochemistry as part of the knowledge of the individual by promoting a perception of the human as a single organism.
Assessment
Individual work
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Title
|
% from total grade
|
Grade
|
|---|---|---|
|
1.
Individual work |
-
|
-
|
|
Study course includes 238 hours of independent work, 22 of those are going to be in the form of organized work for preparation of presentations. Other 216 hours include the following:
• independent study of sources provided in e-studies (books, review articles);
• prior preparation of homework given in e-studies (multiple tasks representing the main concept of the colloquium) for each practical class and covering topics from previous lectures;
• completing on-line tests in e-studies prepared for each practical class for self-control;
• preparation of practical work reports;
• use of ones own knowledge in resolving cases (list of clinical tasks can be found on e-studies);
• analysis of scientific publications;
• individual preparation for colloquiums and exam;
• voluntary research work.
In order to evaluate the quality of the study course as a whole, the student must fill out the study course evaluation questionnaire on the Student Portal.
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Examination
|
Title
|
% from total grade
|
Grade
|
|---|---|---|
|
1.
Examination |
-
|
10 points
|
|
The protocol of laboratory work includes justification of the results obtained, interpretation of the results in the clinical aspect, answers to an additional individual question related to the topic Colloquium include detailed multiple choice questions that require specific theoretical and practical knowledge; various assignments assessing students’ understanding of biochemical processes and their regulation; clinical tasks estimating the ability to use the acquired knowledge by analyzing simplified clinical tasks. Examination (final assessment) includes general multiple choice questions on all topics covered during the study course; various written assignments requiring detailed knowledge of the main digestive and metabolic processes; oral questions which are designed to evaluate students’ general understanding of the relationship between biochemical processes that provide homeostasis in the body and potential dismetabolism or related pathologies. The final grade in study course Medical Biochemistry will be cumulative assessment of interim (50%) and end-of-course (50%) examinations. During the study course there will be 4 Interim examinations – colloquiums. Grade of colloquiums will be cumulative assessment of: • actual results of colloquium (85%); • average results of the mandatory quizzes held after each seminar (15%). For successful preparation for seminars bonus points to the respective colloquium can be gained. If quiz before seminar is filled out with ≥ 70% correct answers, student earns additional 1% to the colloquium grade. To gain access to Interim examinations: • all corresponding E-protocols must be passed (≥ 85% correct answers); • all quizzes after seminars must be held; • for first colloquium (Semester 1) additionally Test "Macromolecules and reaction mechanisms" must be passed. • for fourth colloquium (Semester 2) additionally Presentation "Novelty of the year in biochemistry" must be made. After successful interim examinations one written final exam will be held. |
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Study Course Theme Plan
FULL-TIME
Part 1
-
Lecture
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Modality
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Location
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Contact hours
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|---|---|---|
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Off site
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E-Studies platform
|
2
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Topics
|
Organic Compounds. Functional Groups and Isomers.
|
-
Lecture
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Modality
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Location
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Contact hours
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|---|---|---|
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Off site
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E-Studies platform
|
2
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Topics
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General properties of functional groups. Reaction types (Oxidation – Reduction; Condensation and Hydrolysis; SN1, SN2, E1, E2).
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-
Class/Seminar
|
Modality
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Location
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Contact hours
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|---|---|---|
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On site
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Study room
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1
|
Topics
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Functional groups, isomers, basic organic compounds. Types of reactions: oxidation, reduction; condensation, hydrolysis; replacement, separation. Chemical bonds.
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-
Class/Seminar
|
Modality
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Location
|
Contact hours
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|---|---|---|
|
On site
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Study room
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1
|
Topics
|
Functional groups, isomers, basic organic compounds. Types of reactions: oxidation, reduction; condensation, hydrolysis; replacement, separation. Chemical bonds.
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-
Class/Seminar
|
Modality
|
Location
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Contact hours
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|---|---|---|
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On site
|
Study room
|
1
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Topics
|
Functional groups, isomers, basic organic compounds. Types of reactions: oxidation, reduction; condensation, hydrolysis; replacement, separation. Chemical bonds.
|
-
Lecture
|
Modality
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Location
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Contact hours
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|---|---|---|
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Off site
|
E-Studies platform
|
2
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Topics
|
Carbohydrates. Structure. Properties.
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-
Class/Seminar
|
Modality
|
Location
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Contact hours
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|---|---|---|
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On site
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Study room
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1
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Topics
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Structure, optical and structural isomers, mono -, di -, poly-saccharides.
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-
Class/Seminar
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Modality
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Location
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Contact hours
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|---|---|---|
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On site
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Study room
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1
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Topics
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Structure, optical and structural isomers, mono -, di -, poly-saccharides.
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-
Class/Seminar
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Modality
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Location
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Contact hours
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|---|---|---|
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On site
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Study room
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1
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Topics
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Structure, optical and structural isomers, mono -, di -, poly-saccharides.
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-
Lecture
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Modality
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Location
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Contact hours
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|---|---|---|
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Off site
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E-Studies platform
|
2
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Topics
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Fats, amino acids and proteins. Structures. Qualities.
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-
Class/Seminar
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Modality
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Location
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Contact hours
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|---|---|---|
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On site
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Other
|
1
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Topics
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Sugar reducing properties. Protein denaturation.
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-
Class/Seminar
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Modality
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Location
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Contact hours
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|---|---|---|
|
On site
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Other
|
1
|
Topics
|
Sugar reducing properties. Protein denaturation.
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-
Class/Seminar
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Modality
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Location
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Contact hours
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|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Lipids. Structures. Properties. Amino acids, proteins, structures. Intermolecular forces.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
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|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Lipids. Structures. Properties. Amino acids, proteins, structures. Intermolecular forces.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
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|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Lipids. Structures. Properties. Amino acids, proteins, structures. Intermolecular forces.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
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|---|---|---|
|
Off site
|
E-Studies platform
|
2
|
Topics
|
Enzymes, enzyme classes, enzyme specificities.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
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|---|---|---|
|
On site
|
Other
|
1
|
Topics
|
Influence of temperature and pH on enzyme activity.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
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|---|---|---|
|
On site
|
Other
|
1
|
Topics
|
Influence of temperature and pH on enzyme activity.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
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|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Enzyme classes, recognition and characterization thereof.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
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|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Enzyme classes, recognition and characterization thereof.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
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|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Enzyme classes, recognition and characterization thereof.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
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|---|---|---|
|
Off site
|
E-Studies platform
|
2
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Topics
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Enzyme activation and inhibition mechanisms. Enzyme activity regulation (signalling pathways), vitamins biological catalysts.
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-
Class/Seminar
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Modality
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Location
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Contact hours
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|---|---|---|
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On site
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Laboratory
|
1
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Topics
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Specificity of enzymes.
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-
Class/Seminar
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Modality
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Location
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Contact hours
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|---|---|---|
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On site
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Laboratory
|
1
|
Topics
|
Specificity of enzymes.
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-
Class/Seminar
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Modality
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Location
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Contact hours
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|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Enzyme activation and inhibition mechanisms, for medical purposes. The role of vitamin-based cofactors in biochemical reactions.
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-
Class/Seminar
|
Modality
|
Location
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Contact hours
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|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Enzyme activation and inhibition mechanisms, for medical purposes. The role of vitamin-based cofactors in biochemical reactions.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Enzyme activation and inhibition mechanisms, for medical purposes. The role of vitamin-based cofactors in biochemical reactions.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
Off site
|
E-Studies platform
|
2
|
Topics
|
Digestion and absorption of carbohydrates and proteins.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
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|---|---|---|
|
On site
|
Other
|
1
|
Topics
|
Analysis of glucosidases in digestive juices.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
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|---|---|---|
|
On site
|
Other
|
1
|
Topics
|
Analysis of glucosidases in digestive juices.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Hydrolysis of nutrients, peptide chain cleavage.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
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|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Hydrolysis of nutrients, peptide chain cleavage.
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-
Class/Seminar
|
Modality
|
Location
|
Contact hours
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|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Hydrolysis of nutrients, peptide chain cleavage.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
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|---|---|---|
|
Off site
|
E-Studies platform
|
2
|
Topics
|
Digestion and absorption of lipids, synthesis and functions of bile acids/salts.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
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|---|---|---|
|
On site
|
Other
|
1
|
Topics
|
Functions of the lipase and bile, structure of bile acids.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
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|---|---|---|
|
On site
|
Other
|
1
|
Topics
|
Functions of the lipase and bile, structure of bile acids.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
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|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Nutritional hydrolysis, digestive pathologies.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Nutritional hydrolysis, digestive pathologies.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Nutritional hydrolysis, digestive pathologies.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
1
|
Topics
|
Colloquium I.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
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|---|---|---|
|
On site
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Auditorium
|
1
|
Topics
|
Colloquium I.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
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|---|---|---|
|
On site
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Auditorium
|
1
|
Topics
|
Colloquium I.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
Off site
|
E-Studies platform
|
2
|
Topics
|
Glycolysis
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Regulation of glycolysis, differences in various tissues
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Regulation of glycolysis, differences in various tissues
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Regulation of glycolysis, differences in various tissues
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
Off site
|
E-Studies platform
|
2
|
Topics
|
Oxidative decarboxylation. The Citric Acid (Tricarboxylic acid, Krebs) Cycle.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
1
|
Topics
|
Determination of succinate dehydrogenase.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
1
|
Topics
|
Determination of succinate dehydrogenase.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Anabolic role of CAC. Calculations of acquired energy.
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-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Anabolic role of CAC. Calculations of acquired energy.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Anabolic role of CAC. Calculations of acquired energy.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
Off site
|
E-Studies platform
|
2
|
Topics
|
Bioenergetics, role of ATP in human metabolism. Oxidative stress.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Other
|
1
|
Topics
|
Determination of antioxidant enzymes (catalase, peroxidase).
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Other
|
1
|
Topics
|
Determination of antioxidant enzymes (catalase, peroxidase).
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Oxidative stress. Activators and inhibitors of ETC.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Oxidative stress. Activators and inhibitors of ETC.
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-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Oxidative stress. Activators and inhibitors of ETC.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
Off site
|
E-Studies platform
|
2
|
Topics
|
Anaerobic glycolysis, buffer systems, gluconeogenesis, cori cycle.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Lactic acidosis - symptoms, causes and treatments.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Lactic acidosis - symptoms, causes and treatments.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Lactic acidosis - symptoms, causes and treatments.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
Off site
|
E-Studies platform
|
2
|
Topics
|
Malate-aspartate shuttle. Glycerol-3P shuttle. Pentose Phosphate Pathway. Fructose metabolism.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Oxidation of carbohydrates. Dismetabolism.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Oxidation of carbohydrates. Dismetabolism.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Oxidation of carbohydrates. Dismetabolism.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
Off site
|
E-Studies platform
|
2
|
Topics
|
Metabolism of glycogen and galactose. Blood glucose homeostasis.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Storage of carbohydrates. Dismetabolism.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Other
|
1
|
Topics
|
Storage of carbohydrates. Dismetabolism.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Other
|
1
|
Topics
|
Storage of carbohydrates. Dismetabolism.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
1
|
Topics
|
Colloquium II.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
1
|
Topics
|
Colloquium II.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
1
|
Topics
|
Colloquium II.
|
Total ECTS (Creditpoints):
6.00
Contact hours:
87 Academic Hours
Final Examination:
Test (Semester)
Part 2
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
Off site
|
E-Studies platform
|
2
|
Topics
|
Transport and storage of lipids. Biosynthesis of cholesterol, functions.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Lipoproteins (HDL, LDL), Cholesterol, relation to high CH diet, hypercholesterolaemia.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Lipoproteins (HDL, LDL), Cholesterol, relation to high CH diet, hypercholesterolaemia.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Lipoproteins (HDL, LDL), Cholesterol, relation to high CH diet, hypercholesterolaemia.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
Off site
|
E-Studies platform
|
2
|
Topics
|
Fatty Acid Catabolism, Ketogenesis
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Energy in lipid metabolism – calculations. Carnitine deficiency, ketoacidosis.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Energy in lipid metabolism – calculations. Carnitine deficiency, ketoacidosis.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Energy in lipid metabolism – calculations. Carnitine deficiency, ketoacidosis.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
Off site
|
E-Studies platform
|
2
|
Topics
|
Lipid biosynthesis (Fatty acids, TAGs and membrane Phospholipids).
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Lipid biosynthesis - calculations, related pathologies.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Lipid biosynthesis - calculations, related pathologies.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Lipid biosynthesis - calculations, related pathologies.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
Off site
|
E-Studies platform
|
2
|
Topics
|
Protein catabolism, amino acid oxidation and the production of urea.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Transamination, deamination, role in various tissues.
Importance of clinical biomarkers (ALT and AST).
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Transamination, deamination, role in various tissues.
Importance of clinical biomarkers (ALT and AST).
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Transamination, deamination, role in various tissues.
Importance of clinical biomarkers (ALT and AST).
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
Off site
|
E-Studies platform
|
2
|
Topics
|
Biosynthesis of amino acids, their derivates – biogenic amines, creatine, glutathione. Biosynthesis and degradation of purines, pyrimidines, heme.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Variety of nitrogen containing compounds and their functions in body. Blood and urine biomarkers of nitrogen metabolism.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Variety of nitrogen containing compounds and their functions in body. Blood and urine biomarkers of nitrogen metabolism.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Variety of nitrogen containing compounds and their functions in body. Blood and urine biomarkers of nitrogen metabolism.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
Off site
|
E-Studies platform
|
2
|
Topics
|
Hormones – classification and characteristics based on structure, general action mechanisms.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Hormonal regulation (insulin, glucagon) of metabolism in absorptive/postabsorptive periods.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Hormonal regulation (insulin, glucagon) of metabolism in absorptive/postabsorptive periods.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Hormonal regulation (insulin, glucagon) of metabolism in absorptive/postabsorptive periods.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
1
|
Topics
|
Colloquium III.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
1
|
Topics
|
Colloquium III.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
1
|
Topics
|
Colloquium III.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
Off site
|
E-Studies platform
|
2
|
Topics
|
Liver metabolism.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
The role of liver in detoxification. Enzymes in diagnostics (e.g. ALT, AST, Alkaline phosphatase).
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
The role of liver in detoxification. Enzymes in diagnostics (e.g. ALT, AST, Alkaline phosphatase).
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
The role of liver in detoxification. Enzymes in diagnostics (e.g. ALT, AST, Alkaline phosphatase).
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
Off site
|
E-Studies platform
|
2
|
Topics
|
Obesity, body weight regulation.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Factors related to increased risk of obesity.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Factors related to increased risk of obesity.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Factors related to increased risk of obesity.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
Off site
|
E-Studies platform
|
2
|
Topics
|
Fuel metabolism during exercise.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Aspects that determine the use of different energy systems. Heath benefits provided by regular physical activity.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Aspects that determine the use of different energy systems. Heath benefits provided by regular physical activity.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Aspects that determine the use of different energy systems. Heath benefits provided by regular physical activity.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
Off site
|
E-Studies platform
|
2
|
Topics
|
Can we "run away" from Metabolic Syndrome?
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Metabolic syndrome and type II diabetes.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Metabolic syndrome and type II diabetes.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Metabolic syndrome and type II diabetes.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
Off site
|
E-Studies platform
|
2
|
Topics
|
Metabolic aspects of oncological disease.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Cancer-induced energy metabolic disorders.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Cancer-induced energy metabolic disorders.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Study room
|
1
|
Topics
|
Cancer-induced energy metabolic disorders.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Other
|
1
|
Topics
|
Colloquium IV.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Other
|
1
|
Topics
|
Colloquium IV.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Other
|
1
|
Topics
|
Colloquium IV.
|
Total ECTS (Creditpoints):
8.00
Contact hours:
61 Academic Hours
Final Examination:
Exam (Written)
Bibliography
Required Reading
1.
Nelson, D. L. and Cox, M. M. 2017. Lehninger Principles of Biochemistry. 7th ed. New York: W. H. Freeman & Co (ISBN: 978-1464187964)Suitable for English stream
2.
Baynes, J.W. and Marek H. Dominiczak M.H. 2023. Medical Biochemistry. 6th ed. Elsevier Limited.Suitable for English stream
Additional Reading
1.
Murray, R. K., Granner, D.K., Mayes, P. A. and Rodwell, V.W. 2022. Harper’s Illustrated Biochemistry, 32nd ed. USA: McGraw-Hill Companies.Suitable for English stream
2.
Berg, J. M. , Tymoczko, J.L. and Stryer, L. 2015. Biochemistry. 5th ed. New York: W H Freeman.Suitable for English stream
3.
Devlin, T.M. 2011. Textbook of Biochemistry with Clinical Correlations (Wiley-Liss; 7th ed.). 1240Suitable for English stream
4.
Harvey, R.A. and Ferrier, D.R. 2025. Lippincott's Illustrated Reviews: Biochemistry (Lippincott's Illustrated Teviews Series). 544Suitable for English stream
5.
Miķelsone, V. 2008. Bioķīmija. Jelgava, LLU.
6.
Lieberman, M.A. and Peet, A. 2018. Marks' Basic Medical Biochemistry. 5th ed. Lippincott Williams& WilkinsSuitable for English stream
Other Information Sources
1.
Zinātniskie raksti PubMed žurnālosSuitable for English stream
2.
Currie, E., Schulze A., Zechner R., Walther, T. C., and Farese Jr., R. V. 2013. Cellular Fatty Acid Metabolism and Cancer. Cell Metabolism. 18 (2), 153–161.Suitable for English stream
3.
Kaoutari, A. E., Armougom, F., Gordon, J. I., Raoult, D. and Henrissa, B. 2013. The abundance and variety of carbohydrate-active enzymes in the human gut microbiota. Nature Reviews Microbiology. 11, 497–504.Suitable for English stream
4.
Mudgil, D. and Barak, S., 2013. Composition, properties and health benefits of indigestible carbohydrate polymers as dietaryfiber:A review. International Journal of Biological Macromolecules.61, 1-6. Science Direct. Research gate.Suitable for English stream
5.
Vaishnavi, S. N., Vlassenko, A. G., Rundle, M. M., Snyder, A. Z., et.al. 2010. Proceedings of the National Academy of Sciences. 107 (41) 17757-17762.Suitable for English stream
6.
Wu, F. and Minteer, S. 2015. Krebs Cycle Metabolon: Structural Evidence of Substrate Channeling Revealed by Cross‐Linking and Mass Spectrometry. Angewandte Chemie International Edition, 54: 1851-1854.Suitable for English stream
7.
King, M. W. The medical biochemistry page.Suitable for English stream
8.
Lipid absorption 2016. In Boron, W. and Boulpaep E,. ed. Medical Physiology. 3rd ed. Philadelpia: Elsevier.Suitable for English stream