Veidlapa Nr. M-3 (8)
Study Course Description
Physical Pharmacy
Course Code
LFK_017
Branch of Science
Basic medicine
ECTS
4.00
Target Audience
Pharmacy
LQF
Level 7
Study Type And Form
Full-Time; Part-Time
Study Course Implementer
Course Supervisor
Liāna Orola
Structure Unit Manager
Baiba Mauriņa
Structural Unit
Department of Applied Pharmacy
Contacts
Riga, 21 Consula Street, farmkk@rsu.lv, +371 67061544
About Study Course
Objective
The aim of the course is to provide knowledge of the theoretical and practical principles of physical pharmacy. The tasks of the course are to develop skills to use knowledge of physico-chemical processes and phenomena in pharmacy, to acquire methods of determination of physico-chemical parameters of substances, to interpret acquired data, to improve presentation skills, as well as skills to work with scientific information sources. The course deals with thermodynamics, physical states of substances, phases and their transitions, kinetics, physico-chemical properties of substances in solutions, as well as colloidal systems.
Preliminary Knowledge
Inorganic, organic and analytical chemistry, desirable knowledge of physics and advanced mathematics.
Learning Outcomes
Knowledge
1.As a result of the course students will acquire knowledge of basic principles of drug substance thermodynamics and kinetics, drug state, other phase, physicochemical properties of solutions as well as colloidal systems of drug substances.
Skills
1.Using the acquired knowledge students will be able to characterize the physico-chemical properties of drug substances and will be able to solve problems related to physical pharmacy topics, eg drug substance stability, solubility, phase others, drug substance formulation. Students will acquire the skills to interpret the data obtained from the analysis, as well as to search and use information sources, collaborate in a group and present the results.
Competences
1.Using the acquired knowledge and skills will be able to apply appropriate physico-chemical methods for successful research and characterization of drug substances.
Assessment
Individual work
|
Title
|
% from total grade
|
Grade
|
|---|---|---|
|
1.
Individual work |
-
|
-
|
|
Students have to prepare themselves for laboratory work (theoretical basis of the work, theoretical tasks). Students need to read relevant sections of compulsory literature in addition to lecture materials. Student does independent work outside of study time. It is recommended to fill in the study course survey, evaluating the existing course content and creating proposals for updating the course.
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||
Examination
|
Title
|
% from total grade
|
Grade
|
|---|---|---|
|
1.
Examination |
-
|
-
|
|
Prepared and presented presentation of chosen topic.
|
||
|
2.
Examination |
-
|
-
|
|
Written test (thermodynamics, phases and phase transitions, gases and volatile compounds, solids).
|
||
|
3.
Examination |
-
|
-
|
|
Written test (physicochemical properties of pharmaceuticals in solution, solubility and dissolution).
|
||
|
4.
Examination |
-
|
-
|
|
Written test (chemical kinetics, chemical stability of pharmaceuticals, colloids, surfactants).
|
||
|
5.
Examination |
-
|
-
|
|
Theoretical knowledge and ability to apply theoretical knowledge in practical tasks will be assessed. Student attitude (attendance, interest) will be evaluated. The final grade of the study course consists of the average mark of the colloquium (50%) and the mark of the exam (50%).
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||
Study Course Theme Plan
FULL-TIME
Part 1
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Thermodynamics. Phases and their transitions. Gases and volatiles.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Introductory lesson. Safe working methods. Entrance colloquium (exercises on the forms of concentration).
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Solids.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Laboratory work: Calorimetry.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Physico-chemical properties of drug substances in solutions.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Colloquium: Thermodynamics, phases and their transitions, gases and volatiles, solids.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Solubility and Dissolution.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Laboratory work: Determination of acid dissociation constant.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Chemical kinetics. Chemical stability of the drug substance.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Laboratory work: Determination of solubility.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
2
|
Topics
|
Colloidal systems. Surfactants.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Colloquium: Physico-chemical properties of drug substances in solutions, solubility and dissolution.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Laboratory work: Buffers.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Laboratory work: Emulsions.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Colloquium: Chemical kinetics, chemical stability of drug substances, colloidal systems, surfactants.
|
Total ECTS (Creditpoints):
4.00
Contact hours:
48 Academic Hours
Final Examination:
Exam (Written)
PART-TIME
Part 1
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Thermodynamics. Phases and their transitions. Gases and volatiles.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
4
|
Topics
|
Solids.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
4
|
Topics
|
Physico-chemical properties of drug substances in solutions.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Colloquium: Thermodynamics, phases and their transitions, gases and volatiles, solids.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
4
|
Topics
|
Solubility and Dissolution.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
4
|
Topics
|
Chemical kinetics. Chemical stability of the drug substance.
|
-
Lecture
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Auditorium
|
4
|
Topics
|
Colloidal systems. Surfactants.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Colloquium: Physico-chemical properties of drug substances in solutions, solubility and dissolution.
|
-
Class/Seminar
|
Modality
|
Location
|
Contact hours
|
|---|---|---|
|
On site
|
Laboratory
|
4
|
Topics
|
Laboratory work: Emulsions.
|
Total ECTS (Creditpoints):
4.00
Contact hours:
48 Academic Hours
Final Examination:
Exam (Written)
Bibliography
Required Reading
1.
A. T. Florence., D. Attwood. Physicochemical Principles of Pharmacy: In Manufacture, Formulation and Clinical Use. 6th ed. London: Pharmaceutical Press, 2016 (e-grāmata, pieejama ProQuest Ebook Central e-grāmatu datubāzē).
2.
S. C. Fox. Pharmaceutics. 1st ed. London: Pharmaceutical Press, 2014 (e-grāmata, pieejama ProQuest Ebook Central e-grāmatu datubāzē).
3.
K. A. Connors, S. Mecozzi. Thermodynamics of Pharmaceutical Systems: An Introduction to Theory and Applications. 2nd ed. John Wiley & Sons, 2010 (akceptējams izdevums)
4.
B. Linder. Elementary Physical Chemistry. World Scientific Publishing Co Pte Ltd, 2010 (e-grāmata, pieejama ProQuest Ebook Central e-grāmatu datubāzē). (akceptējams izdevums)
5.
G. Zografi, X. Chen, S. R. Byrn. Solid-State Properties of Pharmaceutical Materials. John Wiley & Sons, 2017 (e-grāmata, pieejama ProQuest Ebook Central e-grāmatu datubāzē).
6.
G. M. Kontogeorgis, S. Kiil. Introduction to Applied Colloid and Surface Chemistry. Wiley, 2016 (e-grāmata, pieejama ProQuest Ebook Central e-grāmatu datubāzē).
Additional Reading
1.
P. Atkins, J. de Paula. Atkins' physical chemistry. 9th ed. Oxford; New York: Oxford University Press, 2010, 972 p.
2.
Student's solutions manual to accompany Atkins' physical chemistry, ninth edition / Charles Trapp, Marshall Cady and Carmen Giunta. New York: W. H. Freeman and Company, 2010. viii, 599 lpp.
3.
CRC handbook of chemistry and physics: a ready-reference book of chemical and physical data. 91st ed. / editor-in-chief, W. M. Haynes; associate editor, David R. Lide. Boca Raton: CRC Press/Taylor & Francis Group, 2019. [2260] lpp.
4.
Physical chemistry: principles and applications in biological sciences / Ignacio Tinoco, Jr. ... [et al.]. 4th ed. Upper Saddle River, N.J.: Prentice Hall, c2002. xix, 740 lpp.
5.
Y. Qiu, Y. Chen, G. G. Z. Zhang, W. Porter, L. Liu, V. Rao, W. Porter. Developing Solid Oral Dosage Forms: Pharmaceutical Theory and Practice. 1st ed. Elsevier Science & Technology, 2017 (e-grāmata, pieejama ProQuest Ebook Central e-grāmatu datubāzē).