Veidlapa Nr. M-3 (8)
Study Course Description
Acute Leukaemias and Myelodysplastic Syndromes
Course Code
RHE_055
Branch of Science
Clinical medicine
ECTS
11.00
Target Audience
Medicine
LQF
Level 8
Study Course Implementer
Course Supervisor
Sandra Lejniece
Residency Speciality
Speciality
Hematologist
Supervisor of Medical Speciality
Sandra Lejniece
Contacts
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About Study Course
Objective
To ensure acquisition and improvement of theoretical knowledge and practical skills related to psychosocial aspects in cases of haematological diseases in accordance with the requirements of the haematology specialty in order to prepare the doctor for certification in the haematology specialty.
Learning Outcomes
Knowledge
1.- Knows about acute leukemias, their classification and cytogenetic changes; - Knows about acquired aplastic anaemia, its causes, clinic, laboratory diagnosis, differential diagnosis, therapy, indications for stem cell transplantation; - Knows about paroxysmal nocturnal hemoglobinuria; - Knows about myelodysplastic syndromes (MDS).
Skills
1.- Able to diagnose and prescribe therapy for acute leukaemia and MDS patients.
Competences
1.Diagnosis and treatment of acute leukaemia and MDS patients.
Assessment
Individual work
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Title
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% from total grade
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Grade
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1.
Individual work |
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-
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1. Independently studies the literature related to the course topics;
2. Independently prepares for seminars;
3. Independently collects disease anamnesis data, objectively examines the patient, formulates a preliminary diagnosis, which is discussed with the lecturer;
4. Gets acquainted with and analyses medical documentation;
5. Completes medical documentation;
6. Independently follows the instructions of the certified specialist.
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Examination
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Title
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% from total grade
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Grade
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|---|---|---|
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1.
Examination |
-
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-
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Mandatory attendance of seminars (100%) and performance of practical work (100%) in each study course.
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Study Course Theme Plan
FULL-TIME
Part 1
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Seminar
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Modality
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Location
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Topics
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The concept of acute leukaemia. Classification of acute leukaemias. Cytogenetic changes in cases of acute leukaemia, their prognostic significance.
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Seminar
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Modality
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Location
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-
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Topics
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Pathogenesis, causes, clinic, laboratory diagnosis, differential diagnosis, therapy of acute lymphoblastic leukaemia, indications for stem cell transplantation.
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Seminar
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Modality
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Location
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-
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Topics
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Pathogenesis, causes, clinic, laboratory diagnosis, differential diagnosis, therapy of acute myeloid leukaemia, indications for stem cell transplantation.
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Seminar
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Modality
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Location
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-
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Topics
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Pathogenesis, causes, clinic, laboratory diagnosis, differential diagnosis, therapy of acquired aplastic anaemia, indications for stem cell transplantation.
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Seminar
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Modality
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Location
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|---|---|---|
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-
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Topics
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Paroxysmal nocturnal hemoglobinuria, its pathogenesis, causes, clinical picture, laboratory diagnosis, differential diagnosis, principles of therapy. Concept of Fanconi anaemia and other congenital bone marrow disorders (Diamond-Blackfan, Shwachman-Diamond syndromes).
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Seminar
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Modality
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Location
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Topics
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Myelodysplastic syndromes (MDS), their causes, pathogenesis, clinic, laboratory diagnosis, morphological changes in blood and bone marrow, differential diagnosis, treatment. Low-risk MDS. Intermediate and high-risk MDS. Chronic myelomonocytic leukaemia.
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Total ECTS (Creditpoints):
11.00
Number of Residency Seminars:
6
Length (weeks):
8
Final Examination:
Residency exam (Theory and practice)
Bibliography
Required Reading
1.
M. Heuser, Y. Ofran, N. Boissel, S. Brunet Mauri, C. Craddock, J. Janssen, A. Wierzbowska & C. Buske, on behalf of the ESMO Guidelines Committee. Acute myeloid leukaemia in adult patients: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-upy. Published in 2020 – Ann Oncol (2020); 31(0): 697-712.
2.
D. Hoelzer, R. Bassan, H. Dombret, A. Fielding, J. M. Ribera, C. Buske on behalf of the ESMO Guidelines Committee. Acute lymphoblastic leukaemia in adult patients: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of Oncology 27 (Supplement 5): v69–v82, 2016 doi:10.1093/annonc/mdw025
3.
NCCN Clinical Practice Guidelines in Oncology. Myelodisplastic syndromes. Version 1.2020.- August27, 2019.
4.
Guillermo Montalban-Bravo,| Guillermo Garcia-Manero .Myelodysplastic syndromes: 2018 update on diagnosis, risk-stratification and management. Am J Hematol. 2018;93:129–147
5.
P. Fenaux, D. Haase, G. F. Sanz, V. Santini, C. Buske on behalf of the ESMO Guidelines Working Group. Myelodysplastic syndromes: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of Oncology 25 (Supplement 3): iii57–iii69, 2014 doi:10.1093/annonc/mdu180
6.
Greenberg PL, Tuechler H, Schanz J, et al. Revised international prognostic scoring system for myelodysplastic syndromes. Blood. 2012;120(12):2454–2465. doi:10.1182/blood-2012-03-420489
7.
Arber DA, Orazi A, Hasserjian R, et al. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood 2016; 127:2391-2405. https://doi.org/10.1182/blood-2016-03-643544
8.
Emile JF, Abla O, Fraitag S, et al. Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages. Blood 2016; 127:2672.
9.
S.Lejniece. Klīniskā hematoloģija. Medicīnas Apgāds, 2020.
10.
Klīnisko analīžu rokasgrāmata. E.Gulbja laboratorija. Izdevējs E.Gulbja laboratorija, 2019.
11.
Alla Rivkina. Plūsmas citometrijas metode hematoloģisko slimību diagnostikā. SIA Medicīnas apgāds, 2019