Veidlapa Nr. M-3 (8)
Study Course Description
Perspective Dosage Forms
Course Code
LFK_032
Branch of Science
Basic medicine; Pharmaceutical Chemistry; Technology of Drug Forms
ECTS
3.00
Target Audience
Pharmacy
LQF
Level 7
Study Type And Form
Full-Time
Study Course Implementer
Course Supervisor
Ance Bārzdiņa
Structure Unit Manager
Baiba Mauriņa
Structural Unit
Department of Applied Pharmacy
Contacts
Riga, 21 Konsula Street, zftk@rsu.lv, +371 67061547
About Study Course
Objective
1. Promote knowledge acquisition and understanding of innovative drug delivery systems (nanoparticles, hydrogels, implant materials, etc.), their diversity, properties, materials used in synthesis, in vitro analysis methods, and potential pharmaceutical applications.
2. Provide in-depth knowledge of pharmacokinetic and pharmacodynamic aspects of the formulation of drug delivery systems and their interactions with human anatomical structures and physiological processes.
Preliminary Knowledge
Basic knowledge in organic chemistry, pharmaceutical chemistry, analytical chemistry, medical chemistry, physical pharmacy, anatomy, normal physiology, pharmacology, pharmaceutical form technology, English language.
Learning Outcomes
Knowledge
1.Successful study course completion results in students being able to • Recognise and characterise the more common drug delivery systems, their classification and their use in the pharmaceutical field; • Characterise and compare polymer and lipid materials and their role in the synthesis of different drug delivery systems; • Identify key in vitro analysis methods for the characterisation of nanoparticles and hydrogels; • Recognise anatomical and physiological obstacles that may hinder the delivery of drugs; • Identify the main physical and chemical parameters of drugs that will influence the selection of the drug delivery system; • Name a variety of internal and external stimuli that may modify the pharmacokinetic and pharmacodynamic parameters of the formulations
Skills
1.As a result of successful study course acquisition, students will be able to: • Choose the appropriate drug delivery system based on the physical and chemical properties of drug; • Define key steps in designing and characterising drug delivery systems; • Identify the type of nanoparticles based on their chemical composition; • Assess the characteristics of given formulations obtained during in vitro testing and assess whether such formulation could be used in the pharmaceutical field.
Competences
1.As a result of the successful completion of the study course, students will be able to evaluate the quality of information available in scientific literature and elsewhere regarding common drug delivery systems and critically evaluate the use possibilities of such delivery systems in the pharmaceutical field. Students will be able to offer drug delivery system-based solutions to a variety of pharmacokinetic and pharmacodynamic problems.
Assessment
Individual work
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Title
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% from total grade
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Grade
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|---|---|---|
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1.
Individual work |
-
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-
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Independent work on the course shall include: listening to video recordings of lectures and learning their contents; successfully completing tests placed in the E-learning environment; preparation for the seminars of the study course; preparation of a presentation on a given topic; completion of the study course evaluation questionnaire |
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Examination
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Title
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% from total grade
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Grade
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|---|---|---|
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1.
Examination |
-
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10 points
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Final assessment in the study course consists of:
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Study Course Theme Plan
FULL-TIME
Part 1
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Lecture
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Modality
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Location
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Contact hours
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|---|---|---|
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Off site
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Video
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2
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Topics
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Innovative drug delivery systems — basic principles, history, pros and cons, classification
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-
Lecture
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Modality
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Location
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Contact hours
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|---|---|---|
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Off site
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Video
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2
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Topics
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Effect of the physical and chemical properties of drugs on the choice of drug delivery system
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-
Lecture
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Modality
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Location
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Contact hours
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|---|---|---|
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Off site
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Video
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2
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Topics
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Anatomical and physiological barriers to the delivery of drugs, mechanisms for overcoming them
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-
Lecture
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Modality
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Location
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Contact hours
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|---|---|---|
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Off site
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Video
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2
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Topics
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Modification of pharmacokinetic and pharmacodynamic parameters of drug delivery systems
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-
Lecture
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Modality
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Location
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Contact hours
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|---|---|---|
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Off site
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Video
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2
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Topics
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Natural and synthetic polymers — characterisation, properties, application in drug delivery system
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-
Lecture
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Modality
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Location
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Contact hours
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|---|---|---|
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Off site
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Video
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2
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Topics
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Lipids – characteristics, properties, application in drug delivery systems
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-
Lecture
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Modality
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Location
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Contact hours
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|---|---|---|
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Off site
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Video
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2
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Topics
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Nanoparticles I — Classification, characteristics, comparison, pros and cons, materials used
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-
Lecture
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Modality
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Location
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Contact hours
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|---|---|---|
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Off site
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Video
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2
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Topics
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Nanoparticles II — synthesis methods, in vitro characterisation, examples
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-
Lecture
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Modality
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Location
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Contact hours
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|---|---|---|
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Off site
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Video
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2
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Topics
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Hydrogels I – types, properties, materials, cross-linking methods
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-
Lecture
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Modality
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Location
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Contact hours
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|---|---|---|
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Off site
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Video
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2
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Topics
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Hydrogels II – in vitro characterisation, types of administration, examples
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-
Lecture
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Modality
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Location
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Contact hours
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|---|---|---|
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Off site
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Video
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2
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Topics
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Transdermal drug delivery systems – types, characteristics, benefits, active ingredients, examples
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-
Lecture
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Modality
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Location
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Contact hours
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|---|---|---|
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Off site
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Video
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2
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Topics
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Vaccines, implants, depot drug forms – types, characteristics, benefits, active ingredients, examples
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-
Lecture
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Modality
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Location
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Contact hours
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|---|---|---|
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Off site
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Video
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2
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Topics
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Future challenges and development directions for drug delivery systems
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-
Class/Seminar
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Modality
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Location
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Contact hours
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|---|---|---|
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On site
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Study room
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2
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Topics
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Seminar – developing a drug delivery system – from an idea to clinical trials
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-
Class/Seminar
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Modality
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Location
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Contact hours
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|---|---|---|
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On site
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Study room
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2
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Topics
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Seminar – presentations on the latest developments in drug delivery systems I
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Class/Seminar
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Modality
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Location
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Contact hours
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|---|---|---|
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On site
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Study room
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2
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Topics
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Seminar - presentations on the latest developments in drug delivery systems II
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Total ECTS (Creditpoints):
3.00
Contact hours:
32 Academic Hours
Final Examination:
Exam (Written)
Bibliography
Required Reading
1.
Drug Delivery Systems. 2020. Edited by Rakesh K. Tekade. London : Academic Press an imprint of ElsevierSuitable for English stream
2.
Emerging Approaches in Novel Drug Delivery System. 2024. Preeti Singh; Gunjan Singh; Amrish Chandra; Nayyar Parvez. Available from: eBook Academic Collection (EBSCOhost)Suitable for English stream
3.
Stimuli Responsive Drug Delivery Systems: From Introduction to Application. 2010. Bajpai, Anil; Shukla, Sandeep; Saini, Rajesh; Tiwari, Atul. Available from: eBook Academic Collection (EBSCOhost)Suitable for English stream
4.
Nanomaterials Evolution and Advancement Towards Therapeutic Drug Delivery (Part I). 2021. Ramesh, Chandra; Nidhi, Gupta; Surendra, Nimesh. Available from: eBook Academic Collection (EBSCOhost)Suitable for English stream
5.
Nanomaterials Evolution and Advancement Towards Therapeutic Drug Delivery (Part II). 2021. Surendra, Nimesh; Nidhi, Gupta; Ramesh, Chandra. Available from: eBook Academic Collection (EBSCOhost).Suitable for English stream
6.
Hydrogels: Synthesis, Characterization and Applications. 2012. Ferreira, Leandro J.; Camara, Fabricio Vitor. Available from: eBook Academic Collection (EBSCOhost)Suitable for English stream
Additional Reading
1.
Applications of Polymers in Drug Delivery. 2014. Misra, Ambikanandan; Shahiwala, Aliasgar. Available from: eBook Academic Collection (EBSCOhost).Suitable for English stream
2.
Drug Carriers. 2022. Edited by Luis Jesús Villarreal-Gómez. Available from: eBook Collection (EBSCOhost).Suitable for English stream
3.
Nanotechnology in Drug Delivery: Strategies, Technologies and Applications. 2013. Haghi, A. K.; Castro, E. A. Available from: eBook Academic Collection (EBSCOhost).Suitable for English stream