Veidlapa Nr. M-3 (8)
Study Course Description
Cell Biology
Course Code
MK_077
Branch of Science
Clinical medicine; Histology and Cytology
ECTS
7.00
Target Audience
Life Science
LQF
Level 7
Study Type And Form
Full-Time
Study Course Implementer
Course Supervisor
Valērija Groma
Structure Unit Manager
Māra Pilmane
Structural Unit
Department of Morphology
Contacts
Riga, Kronvalda boulevard 9, aaiak@rsu.lv, +371 67061551
About Study Course
Objective
Students should acquire knowledge of the cell structure and its functions, be familiar with modern cell research techniques and equipment; they should understand structural and functional changes of the cell, and understand the role of these changes in the pathogenesis of human diseases.
Preliminary Knowledge
Biology, chemistry, histology, anatomy and physiology in correspondence with the bachelor programme.
Learning Outcomes
Knowledge
1.After successful completion of the study course, the student will be able to: • Describe the cell structure and the processes within the cell; • Describe the signalling molecules and explain their role in the regulation of cell processes; • Classify and describe cytoplasmic organelles and inclusions, and explain their role in human pathology; • Identify and describe the methods used for study of cells, their nature and application in the field of biomedicine; • Explain impairment of cell structure and function and how these can contribute to development of disease.
Skills
1.After completion of the study course, the students will be able to evaluate cells when using a light microscope; the student will be able to detect main ultrastructural features of changes in cells; will be able to improve their knowledge of cell research methods and will be able to apply these methods in medicine.
Competences
1.Students will be able to recognize cell and cell microstructure morphology in slides and pictures of the science of cell biology. They will be able to distinguish between healthy and pathological cells generally and they will analyse variations at different cell adaptation processes. They will be able to evaluate the quality and methods of specimens and the way they might be used in clinic.
Assessment
Individual work
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Title
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% from total grade
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Grade
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1.
Individual work |
-
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-
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Analysis of the electron and light microscopy micrographs, short tests and descriptions of schemes that confirm the understanding of fundamentals of cell biology. Self-study using the textbook “Šūna”. Describe electron micrographs.
In order to evaluate the quality of the study course as a whole, the student must fill out the study course evaluation questionnaire on the Student Portal.
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Examination
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Title
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% from total grade
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Grade
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|---|---|---|
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1.
Examination |
-
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-
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Assessment is based on the following criteria: activity during practical classes and attendance, mastery of the material through slide analysis, preparation of presentations, tests, readings, and examination mark.
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Study Course Theme Plan
FULL-TIME
Part 1
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Lecture
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Modality
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Location
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Contact hours
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|---|---|---|
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On site
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Other
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4
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Topics
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Introduction to cell biology. Characteristics of prokaryotic and eukaryotic cells; comparison of the cell structure, cell properties. Diversity of tissue cells.
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-
Lecture
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Modality
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Location
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Contact hours
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|---|---|---|
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On site
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Other
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4
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Topics
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Principles and basic techniques used in cell biology (part I). Light microscopy (bright field optics).
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-
Lecture
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Modality
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Location
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Contact hours
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|---|---|---|
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On site
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Other
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4
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Topics
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Principles and basic techniques used in cell biology (part II). Electron microscopy techniques. Equipment. Histochemistry. Immunohistochemistry, methods, clinical relevance. Studying living cells.
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-
Lecture
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Modality
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Location
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Contact hours
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|---|---|---|
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On site
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Other
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4
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Topics
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Biological membranes. Plasma membrane. Transportacross membranes.
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-
Lecture
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Modality
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Location
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Contact hours
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|---|---|---|
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On site
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Other
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4
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Topics
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Cell surface. Cell membrane and its specialisations. Cell junctions. Cell adhesion.
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-
Lecture
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Modality
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Location
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Contact hours
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|---|---|---|
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On site
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Other
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4
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Topics
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Intracellular organisation – cell organelles (part I).
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-
Lecture
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Modality
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Location
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Contact hours
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|---|---|---|
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On site
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Other
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4
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Topics
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Intracellular organisation – cell organelles (part II).
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-
Lecture
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Modality
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Location
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Contact hours
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|---|---|---|
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On site
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Other
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4
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Topics
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Cell inclusions. Cytoskeleton.
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-
Lecture
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Modality
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Location
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Contact hours
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|---|---|---|
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On site
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Other
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4
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Topics
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Cell communication. Signal molecules and receptors.
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-
Lecture
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Modality
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Location
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Contact hours
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|---|---|---|
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On site
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Other
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4
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Topics
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Extracellular matrix.
The cell nucleus, ribosomes. Analysis of the cell nucleus using light and electron microscopy.
Cell cycle. Cell death.
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-
Class/Seminar
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Modality
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Location
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Contact hours
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|---|---|---|
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On site
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Other
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4
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Topics
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Heterogeneity and differences in organisation of prokaryotic and eukaryotic cells. Cell surface.
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-
Class/Seminar
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Modality
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Location
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Contact hours
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|---|---|---|
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On site
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Other
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4
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Topics
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Electron microscope (operating principles and mode);
electron microscopy methods. Electron microscopy techniques.
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-
Class/Seminar
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Modality
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Location
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Contact hours
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|---|---|---|
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On site
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Other
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4
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Topics
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Basics, meaning and use of immunohistochemistry in medicine. Histochemistry.
Histochemical reactions. Cell cytoplasmic organoids.
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-
Class/Seminar
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Modality
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Location
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Contact hours
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|---|---|---|
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On site
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Other
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4
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Topics
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Cytoskeleton. Cell inclusions. Morphological analysis of the cell nucleus. Cell death: morphological methods for the determination of apoptosis.
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Class/Seminar
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Modality
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Location
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Contact hours
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|---|---|---|
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On site
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Other
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4
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Topics
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Student presentations on cell cytoplasmic organoids.
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Total ECTS (Creditpoints):
7.00
Contact hours:
60 Academic Hours
Final Examination:
Exam (Written)
Bibliography
Required Reading
1.
Groma V., Zalcmane V. Šūna: uzbūve, funkcijas, molekulārie pamati. 2012. Rīga, RSU. 284 lpp. Mācību grāmatas autore ir struktūrvienības darbiniece, no latviešu grāmatu klāsta, patlaban vienīgais pieejamais avots.
2.
Kierszenbaum Abraham L., Tres Laura L. 2019. Histology and Cell Biology: An Introduction to Pathology. 5th Edition. Elsevier. 824 p. ISBN: 9780323673211
3.
Burns E.R., Cave M.D. 2007. Histology and Cell Biology. 2nd Edition. Mosby. 321 p. ISBN-13: 9780323044257, ISBN-10: 0323044255
4.
Paulsen D.F. 2021. Histology and cell biology: Examination and Board Review. 6th Edition. McGraw Hill/ Medical. 453 p. ISBN 978-1-264-26992-1, ISSN 1045-4586
5.
Allen T. 2015. Microscopy: A Very Short Introduction. Oxford University Press. 144 p. ISBN-13: 978-0198701262, ISBN-10: 9780198701262
6.
Eroschenko Victor P. 2017. diFiore's Atlas of Histology: with Functional Correlations (Atlas of Histology (Di Fiore's)). 13th Edition. LWW. 617 p. ISBN-13: 978-1496316769, ISBN-10: 1496316762
7.
Mescher Anthony L. 2021. Junqueira's Basic Histology: Text and Atlas. 16th Edition. McGraw-Hill Education. 480 p. ISBN-10:1260462986, ISBN-13:978-1260462982
8.
Lowe J., Anderson P., Anderson S. 2018. Stevens & Lowe's Human Histology. 5th Edition. Elsevier. 440 p. ISBN: 9780323612807, ISBN: 9780323612791
9.
Karp G., Iwasa J., Marshall W. 2019. Karp's Cell and Molecular Biology. 9th Edition. Wiley. 944 p. ISBN-13: 978-1119598244, ISBN-10: 1119598249
Additional Reading
1.
Boka S., Pilmane M., Kavak V. 2016. Embryology and anatomy for health sciences. Rīgas Stradiņa universitāte. 404 p. ISBN-10: 9984788504, ISBN-13: 978-9984788500. Mācību grāmatas autore ir struktūrvienības darbiniece, no latviešu grāmatu klāsta, patlaban vienīgais pieejamais avots.
2.
Young Barbara, O'Dowd Geraldine, Woodford Phillip. 2013. Wheater's Functional Histology: A Text and Colour Atlas. 6th Edition. Churchill Livingstone. 464 p. ISBN-10: 0702047473, ISBN-13: 978-0702047473
3.
Ovalle William K., Nahirney Patrick C. 2020. Netter's Essential Histology. 3rd Edition. Elsevier. 568 p. ISBN-10:0323694640, ISBN-13:978-0323694643
Other Information Sources
1.
Vrana N. E. 2020. Cell and Material Interface: Advances in Tissue Engineering, Biosensor, Implant, and Imaging Technologies (Devices, Circuits, and Systems). 1st Edition. CRC Press. 294 p. ISBN-13: 978-0367656379, ISBN-10: 036765637X
2.
Freeman J. W. , Banerjee D. 2018. Building Tissues: An Engineer's Guide to Regenerative Medicine (Biomedical Engineering). 1st Edition. CRC Press. 233 p. ISBN-13: 978-1498742801, ISBN-10: 1498742807